A5052404932- X-ray Diffraction in Crystallography
- Neuroscience and Neural Engineering
- Advanced Sensor and Energy Harvesting Materials
- Crystallization and Solubility Studies
- Conducting polymers and applications
- Inflammatory mediators and NSAID effects
- 3D Printing in Biomedical Research
- Crystallography and molecular interactions
- Hydrogels: synthesis, properties, applications
- Supramolecular Self-Assembly in Materials
- Synthesis and biological activity
- Tissue Engineering and Regenerative Medicine
- Polymer Surface Interaction Studies
- Electrospun Nanofibers in Biomedical Applications
- Bone Tissue Engineering Materials
- Electrochemical sensors and biosensors
- Advanced Glycation End Products research
- Infectious Aortic and Vascular Conditions
- Blood properties and coagulation
- Vitamin K Research Studies
- Photoreceptor and optogenetics research
- Aortic aneurysm repair treatments
- Hemostasis and retained surgical items
- Tendon Structure and Treatment
- Fluorine in Organic Chemistry
University of Sheffield
2022
Leibniz Institute of Polymer Research
2022
University of Wollongong
2020
Helmholtz-Zentrum Dresden-Rossendorf
2012-2020
Center for Systems Biology Dresden
2019-2020
TU Dresden
2012-2020
Institute of Cancer Research
2014
Hydrogels based on gelatin have evolved as promising multifunctional biomaterials.Gelatin is crosslinked with lysine diisocyanate ethyl ester (LDI) and the molar ratio of LDI in starting material mixture determines elastic properties resulting hydrogel.In order to investigate clinical potential these biopolymers, hydrogels different ratios (3-fold (G10_LNCO3) 8-fold (G10_LNCO8) excess isocyanate groups) were subcutaneously implanted mice (uni-or bilateral implantation).Degradation...
Abstract Electrically conductive materials that mimic physical and biological properties of tissues are urgently required for seamless brain–machine interfaces. Here, a multinetwork hydrogel combining electrical conductivity 26 S m −1 , stretchability 800%, tissue‐like elastic modulus 15 kPa with mimicry the extracellular matrix is reported. Engineering this unique set enabled by novel in‐scaffold polymerization approach. Colloidal hydrogels nanoclay Laponite employed as supports assembly...
Hydrogels can serve as matrices to mimic natural tissue function and be used for wide‐ranging applications such regeneration drug delivery. Injectable hydrogels are particularly favorable because their uses minimally invasive. However, creating moldable substance injection often results in compromised stability. This study reports an injectable hydrogel system crosslinked by peptide–oligosaccharide noncovalent interaction. The dynamic network shows fast self‐healing, a property essential...
A series of 2,3-diaryl-substituted indoles containing a fluorine or methoxy group was synthesized <italic>via</italic> Fischer indole synthesis, McMurry cyclization, Bischler–Möhlau reaction to identify potential leads for PET radiotracer development.
The EF-hand type calcium-binding protein S100A12 exerts numerous intra- and extracellular functions of (patho)physiological relevance. Therefore, receptors are high interest for research clinical applications. Beside the extensively studied receptor advanced glycation endproducts (RAGE), G-protein coupled more recently, scavenger suggested to be putative receptors. Own findings further information from literature predestined CD36, a class B receptor, as promising candidate. To substantiate...
Immunocompatibility and non-thrombogenicity are important requirements for biomedical applications such as vascular grafts. Here, gelatin-based hydrogels formed by reaction of porcine gelatin with increasing amounts lysine diisocyanate ethyl ester were investigated in vitro this regard. In addition, potential adverse effects the determined using “Hen’s egg test on chorioallantoic membrane” (HET-CAM) a mouse model. The study revealed that immunocompatible, since complement activation was...
Abstract Bioelectronic interfaces employing arrays of sensors and bioactuators are promising tools for the study, repair engineering cardiac tissues. They typically constructed from rigid brittle materials processed in a cleanroom environment. An outstanding technological challenge is integration soft enabling closer match to mechanical properties biological cells Here we present an algorithm direct writing elastic membranes with embedded electrodes, optical waveguides microfluidics using...
Tissue transglutaminase (TGase 2) is proposed to be important for biomaterial–tissue interactions due its presence and versatile functions in the extracellular environment. TGase 2 catalyzes cross-linking of proteins through Ca2+-dependent acyltransferase activity. Moreover, it enhances between fibronectin integrins, which turn mediates adhesion, migration, motility cells. also a key player pathogenesis fibrosis. In this study, we investigated whether present at interface might serve as an...
The seamless integration of electronics with living matter requires advanced materials programmable biological and engineering properties. Here electrochemical methods to assemble semi-synthetic hydrogels directly on electronically conductive surfaces are explored. Hydrogels consisting poly (ethylene glycol) (PEG) heparin building blocks polymerized by spatially controlling the click reaction between their thiol maleimide moieties. gels grown as conformal coatings or 2D patterns ITO, gold,...
Event Abstract Back to Gelatin-based hydrogels as versatile tools for tissue engineering: insights from multimodal imaging in vivo and ex Christoph Tondera1, 2*, Sandra Ullm1, Anne Krüger-Genge3*, Friedrich Jung3, 4*, Tim P. Gebauer3, Axel T. Neffe3, Andreas Lendlein3, Jörg Steinbach1, 2* Jens Pietzsch1, 1 Helmholtz-Zentrum Dresden-Rossendorf, Department Radiopharmaceutical Chemical Biology, Germany 2 Technische Universität Dresden, of Chemistry Food Chemistry, 3 Geesthacht, Institute...