A5088840440- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- Enzyme Structure and Function
- Antimicrobial Peptides and Activities
- Antimicrobial Resistance in Staphylococcus
- Alzheimer's disease research and treatments
- Bacteriophages and microbial interactions
- Biochemical and Structural Characterization
- Protein Structure and Dynamics
- Bacterial Genetics and Biotechnology
- Catalytic Cross-Coupling Reactions
- Synthesis and Biological Evaluation
- Click Chemistry and Applications
- Asymmetric Synthesis and Catalysis
- Supramolecular Chemistry and Complexes
- Lipid Membrane Structure and Behavior
- Synthesis and biological activity
- DNA and Nucleic Acid Chemistry
- Fungal Infections and Studies
- Molecular Sensors and Ion Detection
- Synthesis and Characterization of Heterocyclic Compounds
- Toxin Mechanisms and Immunotoxins
- Metal complexes synthesis and properties
Kazan Federal University
2016-2025
Kazan Scientific Center
2022-2025
A.E. Arbuzov Institute of Organic and Physical Chemistry
2008-2025
Russian Academy of Sciences
2022-2024
Kazan Institute of Biochemistry and Biophysics
2020-2021
Institute of Physics
2015-2020
Amyloids are protein aggregates with a highly ordered spatial structure giving them unique physicochemical properties. Different amyloids not only participate in the development of numerous incurable diseases but control vital functions archaea, bacteria and eukarya. Plants poorly studied systematic group field amyloid biology. Amyloid properties have yet been demonstrated for plant proteins under native conditions vivo. Here we show that seeds garden pea Pisum sativum L. contain...
Abstract For the sake of energy preservation, bacteria, upon transition to stationary phase, tone down their protein synthesis. This process is favored by reversible binding small stress-induced proteins ribosome prevent unnecessary translation. One example conserved bacterial silencing factor (RsfS) that binds uL14 onto large ribosomal subunit and prevents its association with subunit. Here we describe mode Staphylococcus aureus RsfS present a 3.2 Å resolution cryo-EM reconstruction...
Four new NiII, CoII, ZnII, and CuII complexes with the promising anti-tuberculosis drug (E/Z)-N′-((5-Hydroxy-3,4-bis(hydroxymethyl)-6-methylpyridin-2-yl)methylene)-isonicotino-hydrazide (LH) were synthesized characterized by structural methods: single-crystal X-ray diffraction, vibrational spectroscopy, mass spectrometry. The ZnII metal ions form only amorphous phases various morphologies according to spectrometry IR spectroscopy. forms a crystalline 1D coordination polymer relative formula...
For the first time asymmetric and symmetric carboxytriazoleimidazolium derivatives with different structures were synthesized.
Candida albicans is a widespread commensal fungus with substantial pathogenic potential and steadily increasing resistance to current antifungal drugs. It known be resistant cycloheximide (CHX) that binds the E-transfer RNA binding site of ribosome. Because lack structural information, it neither possible understand nature nor develop novel inhibitors. To overcome this issue, we determined structure vacant C. 80S ribosome at 2.3 angstroms its complexes bound inhibitors resolutions better...
Abstract The combined use of 2D NMR correlation experiments and GIAO DFT 13 C chemical shift calculations has allowed a reliable simple structural determination regioisomeric heterocyclic systems that originate from the reactions quinolinone or coumarin derivatives with hydroxylamine. In general, proposed method may find application in compounds. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Ribosome biogenesis is a complex and highly accurate conservative process of ribosomal subunit maturation followed by association. Subunit comprises sequential stages RNA proteins' folding, modification binding, with the involvement numerous RNAses, helicases, GTPases, chaperones, RNA, protein-modifying enzymes, assembly factors. One such factor involved in bacterial 30S binding A (RbfA). In this study, we present crystal (determined at 2.2 Å resolution) NMR structures RbfA as well 2.9...
Artificial gene delivery systems are in great demand from both scientific and practical biomedical points of view. In this paper, we present the synthesis a new click chemistry calix[4]arene precursor with free lower rim water-soluble calixarene triazoles 12 amino-groups on upper (one phenol hydroxyl groups two another containing four butyl or tetradecyl fragments). Aggregation series amino-triazole calixarenes different lipophilicity (calixarene fragments rim) was studied using dynamic...
First-generation gallic acid-based “click” dendrimers with a thiacalix[4]arene core, including symmetric dendrimer four dendrons and amphiphilic alkyl lipoiphilic groups, were synthesized using convergent approach.
Staphylococcus aureus is a bacterial pathogen and one of the leading causes healthcare-acquired infections in world. The growing antibiotic resistance S. obliges us to search for new drugs treatments. As majority antibiotics target ribosome, knowledge its detailed structure crucial drug development. Here, we report cryo-EM reconstruction at 3.2 Å resolution ribosome with P-site tRNA, messenger RNA, 10 RNA modification sites previously not assigned or visualized. resulting model most precise...
In this work, we have proposed a novel universal stimulus-sensitive nanosized polymer system based on decasubstituted macrocyclic structures—pillar[5]arenes and tetrazole-containing polymers. Decasubstituted pillar[5]arenes containing large, good leaving tosylate, phthalimide groups were first synthesized characterized. Pillar[5]arenes primary tertiary amino groups, capable of interacting with polymers, obtained high yield by removing the tosylate protection. According to fluorescence...