A5090405135- Vitamin D Research Studies
- COVID-19 Clinical Research Studies
- Vitamin C and Antioxidants Research
- COVID-19 diagnosis using AI
- Diabetes and associated disorders
- Diet and metabolism studies
- Dermatological and COVID-19 studies
- Biochemical and Structural Characterization
- Biosimilars and Bioanalytical Methods
- Bone health and osteoporosis research
- Thyroid Disorders and Treatments
- Pain Mechanisms and Treatments
- Gut microbiota and health
- Diabetes Management and Research
- Antimicrobial Resistance in Staphylococcus
- Pain Management and Treatment
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Myofascial pain diagnosis and treatment
- Adrenal Hormones and Disorders
- Pancreatic function and diabetes
- Metabolism, Diabetes, and Cancer
- Shoulder Injury and Treatment
- Human Health and Disease
- Healthcare Systems and Public Health
- Gastrointestinal motility and disorders
Federal Almazov North-West Medical Research Centre
2022-2024
Development Agency of Serbia
2022
VA Nasonova Scientific Research Institute of Rheumatology
2021
D. Mendeleyev University of Chemical Technology of Russia
2018
Recent studies showed that a low 25-hydroxyvitamin D (25(OH)D) level was associated with higher risk of morbidity and severe course COVID-19. Our study aimed to evaluate the effects cholecalciferol supplementation on clinical features inflammatory markers in patients A serum 25(OH)D determined 311 COVID-19 patients. Among them, 129 were then randomized into two groups similar concomitant medication. Group I (n = 56) received bolus at dose 50,000 IU first eighth days hospitalization. Patients...
In the last 2 years, observational studies have shown that a low 25-hydroxyvitamin D (25(OH)D) level affected severity of infection with novel coronavirus (COVID-19). This study aimed to analyze potential effect vitamin supplementation in reducing SARS-CoV-2 morbidity and health care workers. Of 128 workers, 91 (consisting 38 medical doctors (42%), nurses 15 attendants (16%)) were randomized into two groups receiving supplementation. Participants group I (
A low 25-hydroxyvitamin D (25(OH)D) level is considered as an independent risk factor for COVID-19 severity. However, the association between vitamin status and outcomes in controversial. In present study we investigate serum 25(OH)D level, immune response, clinical disease course patients with COVID-19. total of 311 hospitalized were enrolled. For a deficiency/insufficiency, prevalence severe was higher than those normal (p < 0.001). The threshold associated mortality 11.4 ng/mL = 0.003,...
Metformin is a first-line drug for DM2 treatment and prevention, but its complex effect on impaired glucose tolerance (IGT), including influence myocardial resistance to ischemia-reperfusion injury, not completely studied. We aimed evaluate the of metformin intestinal microbiota (IM), metabolism, functional morphological characteristics myocardium in rats with IGT. IGT was modelled SPF Wistar high-fat diet streptozotocin nicotinamide injection. Rats were divided into three groups: (without...
Recent studies have demonstrated the relationship between vitamin D deficiency, infection severity and mortality from COVID-19. This study aimed to analyze metabolites cytokine expression levels of COVID-19 patients who were hospitalized with bolus cholecalciferol supplementation. Materials methods: represents next stage open-label randomized pilot conducted by Almazov National Medical Research Centre. A total 44 patients, comparable in demographic, clinical, laboratory instrumental baseline...
Staphylococcus aureus is a Gram-positive bacterium that causes severe illnesses in the human population. The capacity of S. strains to form biofilms on biotic and abiotic surfaces creates serious problems for treatment hospital infections has stimulated efforts develop new means specific protection or immunotherapy.We found rabbit serum raised against crude concentrated liquid culture significantly decreased development staphylococcal biofilm vitro. To discover corresponding antigen, we used...
BACKGROUND: Diabetic peripheral polyneuropathy (DPPN) is a common and early chronic complication of diabetes mellitus (DM). This can be associated with bone tissue damage low-trauma fractures, particularly in type 1 DM. Therefore, evaluating the relationship between DPPN metabolism parameters crucial for clinical practice. AIM : To assess remodeling patients DM varying degrees DPPN. MATERIALS AND METHODS: The study included 90 aged 18 to 55 years on stable insulin therapy past 3 months....
Aim. To create algorithm and risk calculator for predicting the lethal outcome in patients with COVID-19. Materials methods. Based on machine learning approach mortality was developed Almazov National Medical Research Centre using data of hospitalised an established diagnosis COVID-19 (n=4071). Results. This mathematical model, which includes 11 significant features, has been proposed estimation fatal outcomes Clinical Infectious Hospital named after S.P. Botkin. Some key features were not...
SARS-CoV-2, the new coronavirus underlying development of COVID-19 pandemic, has led to a sharp increase in burden on healthcare systems, high mortality and significant difficulties organizing medical care. The aim study was conduct systematic analysis factors affecting course infectious disease patients with diagnosed hospitalized. In order predict determine indications for more aggressive treatment, many different clinical biological markers have been proposed, however, laboratory...
During the COVID-19 pandemic, a high prevalence of vitamin D deficiency and insufficiency remains. Thus, studies carried out on territory Russian Federation (RF) Republic Belarus over last 3 years have shown in population, regardless gender examined persons, geographic location season year. Taking into account known immunomodulatory functions serum 25(OH)D, aim this review was to assess data that were accumulated world, Russia concerned with possible contribution infection, course prognosis,...
Background: Everyone has had shoulder pain at least once in their life. From 70 to 80% of chronic the joint is associated with subacromial impingement syndrome. The use non-steroidal anti-inflammatory drugs (NSAIDs) and glucocorticoids does not always meet needs patients have a number adverse reactions. Local administration PRP HA preparations widely used for pain. However, question effectiveness these different ages been insufficiently studied. Objectives: To compare efficacy GLA by age....
The year 2022 marks the 100th anniversary of vitamin D discovery, however, insufficiency and deficiency is globally widespread both in Russia around world. At same time, COVID-19 pandemic poses a serious challenge to global health. To date, more evidence emerging consider as modifiable severe course risk factor. Current review presents possible mechanisms behind immunomodulatory effects D, well shows relationship between level COVID-19. In addition, therapeutic potential cholecalciferol...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Background. Recently, clinical benefits among COVID-19 patients, received vitamin D were demonstrated. Features of metabolism in the acute period remain unclear. Objective. To assess level 25(OH)D and 1,25(OH)2D hospitalized patients cholecalciferol effect on metabolites dynamic. Materials methods. Group 1 (n = 22) bolus therapy at a total dose 100,000 IU. 2 did not receive supplementation. Serum levels estimated for each group first ninth day hospitalization. Results. On hospitalization...
Introduction . Insulin therapy is the only treatment for type 1 DM and one of options intensifying 2 DM. The production own insulin biosimilars will increase patients access to providing drugs can potentially reduce medical costs on healthcare government. Aim Compare equivalence pharmacokinetics (PK) pharmacodynamics (PD), safety, efficacy, immunogenicity between biosimilar RinLis®, 100 IU/ml (LLC GEROPHARM, Russia) original Humalog®, (Lilly France, France). Materials methods clinical trial...
B ACKGROUND. Glucose metabolism disorders (GMD) were detected both in acute and post-COVID, however, its pathogenic aspects remain unclear. AIM. To analyze the occurrence of GMD post-COVID patients who have had moderate severe COVID-19 without previously known disorders, evaluate expression SARS-CoV-2 proteins entry factors pancreas COVID-19. METHODS. Among 187 hospitalized with confirmed 141 diagnosed underwent follow-up visits. The examination for all included anthropometric measurement...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)