A5033849007- Virus-based gene therapy research
- RNA Interference and Gene Delivery
- SARS-CoV-2 and COVID-19 Research
- Cancer Cells and Metastasis
- Angiogenesis and VEGF in Cancer
- Viral gastroenteritis research and epidemiology
- Advanced biosensing and bioanalysis techniques
- COVID-19 Clinical Research Studies
- Prostate Cancer Treatment and Research
- Vaccine Coverage and Hesitancy
- Tracheal and airway disorders
- Immune Response and Inflammation
- Pediatric health and respiratory diseases
- Cytomegalovirus and herpesvirus research
- Viral Infectious Diseases and Gene Expression in Insects
- Animal Virus Infections Studies
- Viral Infections and Immunology Research
- COVID-19 epidemiological studies
- Helicobacter pylori-related gastroenterology studies
- HIV/AIDS drug development and treatment
- Cystic Fibrosis Research Advances
- Immune Cell Function and Interaction
- Mechanical Systems and Engineering
- Industrial Engineering and Technologies
- Neurological Disorders and Treatments
Ministry of Health of the Russian Federation
2020-2023
Gamalei Institute of Epidemiology and Microbiology
2018-2021
Engelhardt Institute of Molecular Biology
2013-2016
Oncological Dispensary No. 2
2015
Russian Academy of Sciences
2010-2011
While the world is experiencing another wave of COVID-19 pandemic, global vaccination program hampered by an evident shortage in supply licensed vaccines. In effort to satisfy vaccine demands we developed a new single-dose based on recombinant adenovirus type 26 (rAd26) vector carrying gene for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) glycoprotein - "Sputnik Light".We conducted open label, prospective, non-randomised phase 1/2 trial aimed assess safety,...
Angiogenesis is a key factor of tumor progression. Considering, that the vessels are heterogeneous and differ in morphology clinical significance, purpose this research was to study morphological features their relationship with characteristics breast cancer (BC). In pilot samples received from 59 patients T1-T2 stages ductal invasive carcinomas were included. The sections stained hematoxylin eosin immunohistochemically using antibodies CD34. number different types assessed microscopically...
To protect young individuals against SARS-CoV-2 infection, we conducted an open-label, prospective, non-randomised dose-escalation Phase 1/2 clinical trial to evaluate the immunogenicity and safety of prime-boost “Sputnik V” vaccine administered at 1/10 1/5 doses adolescents aged 12–17 years. The study began with vaccination older cohort (15-to-17-year-old participants) lower (1/10) dose then expanded whole group (12-to-17-year-old participants). Next, was used according same scheme. Both...
RNA interference (RNAi) is a powerful method used for gene expression regulation. The increasing knowledge about the molecular mechanism of this phenomenon creates new avenues application RNAi technology in treatment various human diseases. However, delivery mediators, small interfering RNAs (siRNAs), to target cells major hurdle. Effective and safe pharmacological use siRNAs requires carriers that can deliver siRNA its site development methods protection these fragile molecules from vivo...
Objectives Vaccination remains the most effective response to COVID-19 pandemic. Most vaccines use two-dose regimens. In turn, single-dose also have high potential, since, on one hand, they simplify vaccination program, make it more accessible and convenient for people around world, other are better suited subsequent revaccination. However, there is not enough data effectiveness of vaccine variants against new genetic lines assess their current potential. It clear how much a single dose...
Induction of a robust and long-lived mucosal immune response during vaccination is critical to achieve protection against numerous pathogens. However, traditional injected vaccines are generally poor inducers immunity. One the effective strategies improve vaccine efficacy incorporation adjuvant molecules that enhance polarize adaptive reactions. Effects Syk-coupled lectin receptor agonists as adjuvants induce reactions parenteral immunization not fully studied. We now report...
Adenoviruses cause a wide variety of human infectious diseases. Adenoviral conjunctivitis and epidemic keratoconjunctivitis are commonly associated with species D adenoviruses. Currently, there is no sufficient or appropriate treatment to counteract these adenovirus infections. Thus, an urgent need for new etiology-directed therapies selective activity against To address this problem, the adenoviral early genes E1A E2B (viral DNA polymerase) seem be promising targets. Here, we propose...
Adenovirus infections are characterized by widespread distribution. The lack of causal therapy, which is effective in treating this group diseases, explains the need for new therapeutic drugs. Notably, anti-adenoviral activity [4-(phenoxy)benzyl]-5-(phenylamino)-6-azauracil, 1-[4-(phenoxy)benzyl]-5-(morpholino) uracil, 1-[4-(4-chlorophenoxy)benzyl]-5-(morpholino) and 1-[4-(4-fluorophenoxy)-benzyl]-5-(morpholino) uracil was observed.
Background: While the world is experiencing another wave of COVID-19 pandemic, global vaccination program hampered by obvious shortage in supply licensed vaccines. Development new vaccines that are easy to manufacture and administer highly desirable overcome hurdles vaccine scaling up distribution, especially developing countries. In effort satisfy demands we developed a single dose based on recombinant adenovirus type 26 (rAd26) vector carrying gene for severe acute respiratory syndrome...
Цель исследования - изучение морфологии опухолевых сосудов и ее связи с клинико-морфологическими характеристиками рецепторным статусом новообразования при раке молочной железы (РМЖ). Материалы методы. Образцы опухолей 66 пациенток T1-2 стадиями инвазивного РМЖ неспецифического типа окрашивали гематоксилином Майера эозином, а также иммуногистохимическим методом использованием антител к CD34. Результаты. Проведенное исследование позволило выделить следующие типы сосудов: обычные капилляры,...
The main cause of death in patients with cystic fibrosis (CF) is infectious process the lungs, particular, chronic lung infections caused by various pathogens, most often a combination bacteria, fungi, or viruses. Data on mixed bacterial and viral-bacterial from domestic foreign sources are fragmentary sparse. dominant associations viral pathogens have not been studied properly, data their epidemiological significance lacking. aim this study was to assess prevalence substantiate need for...
Introduction. COVID-19 is characterized by a varied clinical course.
 The aim of the work was to identify associations SNPs hemostatic system genes with COVID-19.
 Materials and methods. DNA isolated from patients (n=117) healthy participants (n=104). All infected were divided into 3 groups, depending on disease severity assessment, which appreciated NEWS2. Another group consisted participants, who had asymptomatic infection in past. Determination FGB (-455 G/A), FII (20210 FV...
Human adenoviruses, in particular D8, D19, and D37, cause ocular infections. Currently, there is no available causally directed treatment, which efficiently counteracts adenoviral infectious diseases. In our previous work, we showed that gene silencing by means of RNA interference an effective approach for downregulation human species D adenoviruses replication. this study, compared the biological activity siRNAs their modified analogs targeting DNA polymerase. We found one selectively...
Background/Objective: The role of circulating endothelial cells in tumor progression was noted by many researchers. purpose this research to study the relationship free (unrelated wall vessel) CD34 positive (F-CD34+) located lumen vessels with features angiogenesis, clinical and morphological characteristics breast cancer (BC). Materials Methods: samples received from 45 patients T1-T2 stages ductal invasive carcinomas were included study. sections stained immunohistochemically using...