A5057448474- Cancer Treatment and Pharmacology
- Immunotherapy and Immune Responses
- Spaceflight effects on biology
- Bacillus and Francisella bacterial research
- Blood Pressure and Hypertension Studies
- Cell Adhesion Molecules Research
- Chemotherapy-induced cardiotoxicity and mitigation
- Chemokine receptors and signaling
- Monoclonal and Polyclonal Antibodies Research
- Heart Rate Variability and Autonomic Control
- Microtubule and mitosis dynamics
- Bacterial Identification and Susceptibility Testing
- Cardiovascular Health and Disease Prevention
- Bacterial Genetics and Biotechnology
- Antibiotic Resistance in Bacteria
- MicroRNA in disease regulation
- Angiogenesis and VEGF in Cancer
- Electron Spin Resonance Studies
- Cancer Cells and Metastasis
- Thermoregulation and physiological responses
- HER2/EGFR in Cancer Research
- Nuclear Receptors and Signaling
- thermodynamics and calorimetric analyses
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Healthcare Systems and Public Health
University of Lausanne
2019-2024
Grodno State Medical University
2024
Institute of Biomedical Problems
2019-2023
Ministry of Health of the Russian Federation
2023
University Hospital of Lausanne
2019-2021
Lomonosov Moscow State University
2018
Friedrich Miescher Institute
2012-2018
Gamalei Institute of Epidemiology and Microbiology
2013-2015
Russian Academy of Sciences
2015
Stavropol State Medical University
2013-2014
Copper chelators could help to reduce metastasis from breast tumors.
Abstract An important step in the process of metastasis from primary tumor is invasive spread into surrounding stroma. Using an vivo invasion assay, we have previously shown that imposed gradients epidermal growth factor (EGF) or colony-stimulating factor-1 (CSF-1) can induce through EGF/CSF-1 paracrine loop between cancer cells and macrophages. We now report induced by other ligands also relies on this loop. show MTLn3 breast overexpressing ErbB3 exhibit enhanced compared with control...
Neu (HER2/ErbB2) is overexpressed in 25% to 30% of human breast cancer, correlating with a poor prognosis. Researchers previous studies who used the mouse mammary tumor virus Neu-transgenic model (MMTV-Neu) demonstrated that Neu-YB line had increased production CXCL12 and metastasis, whereas Neu-YD decreased metastasis. In this study, we examined role cell invasion malignancy. We studied microenvironment using multiphoton intravital imaging, vivo intravasation assays. signaling was altered...
Summary In vitro regeneration of complete organisms from diverse cell types is a spectacular property plant cells. Despite the great importance for breeding and biotechnology, its molecular basis still largely unclear many important crop plants have remained recalcitrant to regeneration. Hormone‐exposure protocols trigger de novo formation either roots or shoots callus tissue demonstrate auxin cytokinin signaling pathways, genetic differences in these pathways may contribute highly divergent...
Abstract Apoptosis repressor with caspase recruitment domain (ARC) inhibits both death receptor- and mitochondrial/ER-mediated pathways of apoptosis. Although expressed mainly in terminally differentiated cells, ARC is markedly upregulated a variety human cancers, where its potential contributions have not yet been defined. In this study, we provide evidence multiple critical pathophysiologic functions for breast carcinogenesis. the polyoma middle T-antigen (PyMT) transgenic mouse model...
Glioblastoma (GBM) is one of the most aggressive human brain tumors, with a median survival 15-18 months. There desperate need to find novel therapeutic targets. Various receptor protein kinases have been identified as potential targets; however, response rates in clinical studies somewhat disappointing. Targeting spleen tyrosine kinase (SYK), which acts downstream range oncogenic receptors, may therefore show more promising results.Kinase expression tumor samples including GBM and low-grade...
Introduction: Human blood normally contains circulating cell-free DNA (cirDNA). Cell-free (cfDNA) present in cell culture medium is termed extracellular (ecDNA). Its concentration, GC content and oxidation level depend on physiological state of the organism. cirDNA could probably be one aggressive factors encountered by therapeutic stem cells. The authors hypothesize that oxidized influence their survival rate. They aimed to uncover effects ecDNAs, including ecDNA cultivated primary tumor...
The extracellular serine protease inhibitor serpinE2 is overexpressed in breast cancer and has been shown to foster metastatic spread. Here, we investigated the hypothesis that creates tumor-promoting conditions tumor microenvironment (TME) by affecting matrix remodeling. Using two different models, show blocking serpinE2, either knock-down (KD) cells or response a binding antibody, decreases dissemination from primary tumors lungs. We demonstrate KD antibody treatment there are dramatic...
Acute myeloid and lymphoblastic leukemia are poor prognosis hematologic malignancies, which disseminate from the bone marrow into blood. Blast interactions with selectins expressed by vascular endothelium promote development of drug resistance leukostasis. While role in initiating blast adhesion is established, our knowledge involved selectin ligands incomplete. Using various primary acute cells U937 monoblasts, we identified here functional myeloblasts lymphoblasts performing biochemical...
A method is described for determining the localization of alkaline phosphatase in cells E. coli B with electron microscope. Enzyme activity, determined by deposition inorganic phosphate, located exterior layer cell wall.
Background . Cell free DNA (cfDNA) circulates throughout the bloodstream of both healthy people and patients with various diseases. CfDNA is substantially enriched in its GC-content as compared human genomic DNA. Principal Findings Exposure haMSCs to GC-DNA induces short-term oxidative stress (determined H2DCFH-DA) results single- double-strand breaks (comet assay γ H2AX, foci). As a result cells significantly increases expression repair genes ( BRCA1 (RT-PCR), PCNA (FACS)) antiapoptotic...
Introduction . Detection of the cardiotoxic effect during chemotherapy (CT) for malignant neoplasms is one most important tasks a practicing physician. Purpose: to study changes in left ventricular systolic and diastolic function using echocardiography (EchoCG) with doxorubicin patients primary breast cancer (BC) identify potential markers early cardiotoxicity (CT). Material Methods The included 100 confirmed diagnosis who were treated at health care institution “Grodno University Clinic”...
Abstract The malignant microenvironment plays a major role in the development of resistance to therapies and occurrence relapses acute myeloid leukemia (AML). We previously showed that interactions AML blasts with bone marrow macrophages (MΦ) shift their polarization towards protumoral (M2-like) phenotype, promoting drug resistance; we demonstrated inhibiting colony-stimulating factor-1 receptor (CSF1R) repolarizes MΦ an antitumoral (M1-like) phenotype other factors may be involved....
Changes in gene expression within the hippocampus induced by denervation after electrolytic fimbria-fornix lesion rat were compared to morphological and biochemical alterations. Fimbria-fornix results degeneration of hippocampal cholinergic terminals as evidenced a sustained (2 days 1 month) decrease cholineacetyltransferase (ChAT) activity (50%). These changes accompanied growth associated protein 43 (GAP-43) immunoreactivity all layers 4 followed subsequent increase return normal levels 20...
Relapse is a major issue in acute myeloid leukemia (AML) and while the contribution of gene mutations developing drug resistance well established, little known on role macrophages (MΦs) an AML cell microenvironment. We examined whether myeloblasts could educate MΦs to adopt protumoral orientation supporting myeloblast survival therapy. Flow cytometry analyses demonstrated that M2-like CD163+ are abundantly present, at diagnosis, bone marrow patients. showed myeloblasts, or their conditioned...
and arterial hypertension for the planning of timely effective prevention . Design methods. We enrolled 147 people: with optimal normal BP — 81, high 30 men, 36 controls. Ambulatory monitoring (ABPM) nas performed in offi ce at setting ≪typical working day≫ or 24 +- 1,5 hours 15 minute intervals between measurements during day night, respectively. Results. Young people differ from subjects by a variety ABPM indices. However, changes are lower, but similar to those observed patients evident...