A5044009447- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- HIV/AIDS Research and Interventions
- Cellular Mechanics and Interactions
- Microtubule and mitosis dynamics
- Fungal and yeast genetics research
- RNA Research and Splicing
- Neurogenetic and Muscular Disorders Research
- Cancer-related Molecular Pathways
- Poverty, Education, and Child Welfare
- Neurogenesis and neuroplasticity mechanisms
- Cellular transport and secretion
- Virology and Viral Diseases
- Blood groups and transfusion
- Biotin and Related Studies
- RNA modifications and cancer
- Cell death mechanisms and regulation
- Cytomegalovirus and herpesvirus research
- Parvovirus B19 Infection Studies
- Child Nutrition and Water Access
- Genetics, Aging, and Longevity in Model Organisms
- Galectins and Cancer Biology
- IL-33, ST2, and ILC Pathways
- Nerve injury and regeneration
- RNA regulation and disease
Centre de Recherche en Cancérologie de Marseille
2010-2022
Inserm
1998-2021
Institut Paoli-Calmettes
2010-2021
Institut Pprime
2021
Centre National de la Recherche Scientifique
1998-2021
Aix-Marseille Université
2010-2017
Institut de Biologie du Développement Marseille
1998-2003
Agouron Institute
1995
Institut de Virologie
1991
Génétique et Immunologie des Maladies Parasitaires
1990
Copper chelators could help to reduce metastasis from breast tumors.
Microtubules (MTs) contribute to key processes during cell motility, including the regulation of focal adhesion turnover and establishment maintenance orientation. It was previously demonstrated that ErbB2 receptor tyrosine kinase regulated MT outgrowth cortex via a complex Memo, GTPase RhoA, formin mDia1. But mechanism linked this signaling module MTs remained undefined. We report ErbB2-induced repression glycogen synthase kinase-3 (GSK3) activity, mediated by Memo mDia1, is required for...
Abstract Functions of septin cytoskeletal polymers in tumorigenesis are still poorly defined. Their role the regulation cytokinesis and cell migration were proposed to contribute cancer associated aneuploidy metastasis. Overexpression Septin 9 (Sept9) promotes lines. SEPT9 mRNA protein expression is increased breast tumors compared normal peritumoral tissues amplification gene was positively correlated with tumor progression. However, existence multiple isoforms Sept9 a confounding factor...
Significance Microtubule dynamics is tightly regulated during fundamental biological processes such as mitosis, thereby representing a major target for anticancer therapies. To better understand the molecular mechanisms underlying organization of microtubule network, we systematically investigated proteins interacting with EB1, regulator microtubules dynamics. We identified specific isoform myomegalin, which termed “SMYLE,” that assembles macromolecular complex associated centrosome,...
Activation of the Fas death receptor leads to motoneurons in culture. To investigate role programmed cell and pathological situations, we used several mutant mice deficient for signaling made a novel transgenic FADD-DN (FAS-associated domain-dominant-negative) strain. In vitro, from all these were found be resistant activation show delay trophic deprivation-induced death. During normal development vivo, no changes motoneuron survival observed. However, number surviving was twofold higher...
Abstract Spinal muscular atrophy (SMA) is an autosomal recessive disease characterized by a progressive degeneration of motoneurons in spinal cord and brainstem. The telomeric copy duplicated gene termed survival motor neuron ( smn ), which maps to chromosome 5q13, has been found be deleted most patients. encoded product novel protein recently shown accumulate specific nuclear organelles gemini coiled bodies, GEMS), play part the formation spliceosome complex. We have cloned sequenced rat...
ABSTRACT Septins, a family of GTP-binding proteins that assemble into higher order structures, interface with the membrane, actin filaments and microtubules, are thus important regulators cytoarchitecture. Septin 9 (SEPT9), which is frequently overexpressed in tumors mutated hereditary neuralgic amyotrophy (HNA), mediates binding septins to but molecular determinants this interaction remained uncertain. We demonstrate short microtubule-associated protein (MAP)-like motif unique SEPT9 isoform...
The production of human immunodeficiency virus type 1 (HIV-1) progeny was followed in the U937 promonocytic cell line after stimulation either with retinoic acid or PMA, and purified monocytes macrophages. Electrophoretic mobility shift assays Southwestern blotting experiments were used to detect binding cellular transactivation factor NF-KB double repeat-KB enhancer sequence located long terminal repeat. PMA treatment, not treatment cells acts inducing expression nuclei. In nuclear extracts...
Abstract Metastatic progression is the leading cause of mortality in breast cancer. Invasive tumor cells develop invadopodia to travel through basement membranes and interstitial matrix. Substantial efforts have been made characterize molecular composition. However, their full identity still missing due difficulty isolating them. To fill this gap, we developed a non-hypothesis driven proteomic approach based on BioID proximity biotinylation technology, using invadopodia-specific protein...
iASPP is a protein mostly known as an inhibitor of p53 pro-apoptotic activity and predicted regulatory subunit the PP1 phosphatase, which often overexpressed in tumors. We report that associates with microtubule plus-end binding EB1, central regulator dynamics, via SxIP motif. silencing or mutation motif led to defective capture at cortex mitotic cells, leading abnormal positioning spindle. These effects were recapitulated by knockdown membrane-to-cortex linker Myosin-Ic (Myo1c), we...
ErbB2 physically interacts with MEMO by pull down (View interaction 1, 2, 3, 4, 5, 6) Receptor tyrosine kinases are major players in transduction of extracellular cues into intracellular signals that allow a cell to adjust the environment. Members ErbB family transmembrane receptor expressed many different tissues. These epidermal growth factor receptors play crucial role growth, differentiation and migration. Aberrant expression leads dramatic physiological consequences such as malignant...
Formation of large syncytia and rapid cell killing are characteristics the Zairian human immunodeficiency virus type 1 isolate HIV-1-NDK, which is highly cytopathic for CD4+ lymphocytes in comparison with HIV-1-LAV prototype. Chimeric viruses containing different combinations HIV-1-NDK genetic determinants corresponding to splice donor, packaging signal, coding sequence p18gag protein together EcoRI5278-XhoI8401 fragment were obtained by polymerase chain reaction-directed recombination....