A5100668610- BRCA gene mutations in cancer
- Lung Cancer Treatments and Mutations
- Monoclonal and Polyclonal Antibodies Research
- Iron Metabolism and Disorders
- Nutrition, Genetics, and Disease
- Uterine Myomas and Treatments
- COVID-19 and healthcare impacts
- Phagocytosis and Immune Regulation
- Biomedical Ethics and Regulation
- Urinary and Genital Oncology Studies
- MicroRNA in disease regulation
- Erythropoietin and Anemia Treatment
- Ovarian cancer diagnosis and treatment
- Cervical Cancer and HPV Research
- RNA modifications and cancer
- Extracellular vesicles in disease
- Brain Metastases and Treatment
- Acupuncture Treatment Research Studies
- Ferroptosis and cancer prognosis
- Cancer Diagnosis and Treatment
- Genomics and Rare Diseases
- Traditional Chinese Medicine Studies
- Chemokine receptors and signaling
- Radiomics and Machine Learning in Medical Imaging
- Plasma Applications and Diagnostics
Weill Cornell Medicine
2019-2024
Cornell University
2016-2024
Shanghai Jiao Tong University
2012-2023
Shanghai Chest Hospital
2000-2023
Center for High Pressure Science & Technology Advanced Research
2023
NewYork–Presbyterian Hospital
2016-2022
Presbyterian Hospital
2016-2022
New York Hospital Queens
2016-2022
Columbia University Irving Medical Center
2022
Texas Health Dallas
2022
Abstract 4-1BB is an inducible receptor-like protein expressed in both cytolytic and Th cells. Optimal induction of mRNA T cells required PMA ionomycin stimulation, indicating that kinase C activation increases intracellular Ca2+ were for its expression. was categorized as early gene since the synthesis inhibitor, cycloheximide, blocked mRNA. A rat mAb, 53A2, generated against recombinant soluble used to characterize this molecule. a 30-kDa glycoprotein appears exist monomer 55-kDa dimer on...
Objective: To evaluate the perioperative morbidity and mortality of patients with COVID-19 who undergo urgent emergent surgery. Summary Background Data: Although infection is usually associated mild disease, it can lead to severe respiratory complications. Little known about outcomes COVID-19. Methods: We examined underwent surgery at 2 hospitals in New York City from March 17 April 15, 2020. Elective surgical procedures were cancelled throughout routine, laboratory based screening was...
Neu (HER2/ErbB2) is overexpressed in 25% to 30% of human breast cancer, correlating with a poor prognosis. Researchers previous studies who used the mouse mammary tumor virus Neu-transgenic model (MMTV-Neu) demonstrated that Neu-YB line had increased production CXCL12 and metastasis, whereas Neu-YD decreased metastasis. In this study, we examined role cell invasion malignancy. We studied microenvironment using multiphoton intravital imaging, vivo intravasation assays. signaling was altered...
Abstract Iron accumulation in tumors contributes to disease progression and chemoresistance. Although targeting this process can influence various hallmarks of cancer, the immunomodulatory effects iron chelation tumor microenvironment are unknown. Here, we report that treatment with deferiprone, an FDA-approved chelator, unleashes innate immune responses restrain ovarian cancer. Deferiprone reprogrammed cancer cells toward immunostimulatory state characterized by production type-I IFN...
<p>Table S4 describes the organoids used in this study</p>
<p>Figure S1. (a) Effect of dietary iron levels on ovarian cancer progression. Figure S2. Flow cytometry gating strategy for the analysis peritoneal cells from mice bearing ID8Defb29/Vegfa tumors that were treated with deferiprone as single agent or in combination cisplatin. S3. (a-f) Wild-type female implanted ID8-Defb29/Vegfa and described Fig 2 d. S4. Representative images NKp46 staining entire omentum. S5. MTT assays ID8-Defb29/Vegfa, PPNM, MP different concentrations 12, 24, 48...
<p>Table S3 contains all statistically significant DEGs from RNAseq data</p>
<p>Table S2 contains all the information related to mass spectrometry</p>
<p>Table S5 contains all the primers used in this study</p>
<p>Table S1 describes all the human ascites samples analyzed</p>
The objective of this study is to explore clinical risk factors for venous thromboembolism (VTE) in postoperative lung cancer patients order provide a basis the prevention and treatment VTE.A total 1,001 were retrospectively analyzed. Each patient was confirmed with surgical pathology diagnosis had complete follow-up record. VTE identified combination spiral computed tomography (CT), pulmonary angiography, color Doppler ultrasound. We used life table method create an occurrence frequency...
BACKGROUND Platinum-based chemotherapy is the most effective regimen for nasopharyngeal carcinoma, which presents highly invasive and metastatic activity. However, dose-related toxicity of agents limits dose administration. Astragalus polysaccharide (APS) major active ingredient extracted from Chinese herb Radix Astragali proven to be against carcinomas. We aimed assess chemosensitizing effects polysaccharides on carcinoma in vitro vivo explore underlying mechanism. MATERIAL AND METHODS used...
Tumor cells must overcome apoptosis to survive throughout metastatic dissemination and distal organ colonization. Here, we show in the Polyoma Middle T mammary tumor model that N-cadherin (Cdh2) expression causes Slug (Snai2) upregulation, which turn promotes carcinoma cell survival. was dramatically upregulated metastases relative primary tumors. Consistent with a role metastasis, knockdown suppressed lung colonization by decreasing survival at sites, but had no effect on invasion or...
4-1BB is a 30-kDa inducible T cell Ag, and expressed predominantly as 55-kDa dimer on both CD4+ CD8+ lymphocytes. The cytoplasmic tail of contains the sequence Cys-Arg-Cys-Pro, which similar to Cys-X-Cys-Pro, mediates binding CD4 CD8 molecules protein tyrosine kinase p56lck. An anti-4-1BB mAb, 53A2, was used determine whether may associate with 53A2 mAb specifically recognized line, CTLL-2, coimmunoprecipitated 56-kDa along 4-1BB. Peptide mapping indicated that phosphoprotein identical...
This study was designed to establish a biomarker risk model for predicting bone metastasis in stage III non-small cell lung cancer (NSCLC). The consists of 105 cases NSCLC, who were treated and followed up. patients divided into group (n = 45) non-bone (other visceral those without recurrence) 60). Tissue microarrays constructed immunohistochemical 10 molecular markers associated with metastasis, based on which established via logistic regression analysis the metastases. prospectively...
Macrophage inflammatory protein-1 alpha (MIP-1 alpha) is a member of the intercrine/chemokine family which consists basic, heparin-binding, small molecular weight proteins. We have previously shown that T cell line, CTLL-R8, carried high-affinity receptors for MIP-1 and proliferation CTLL-R8 cells was inhibited by murine recombinant (mr) alpha. extended our previous studies to resting splenic lymphocytes determine whether inhibition general property The approximately 680 binding sites...
Background: This study assessed the diagnostic performance of a deep learning (DL)-based model for differentiating malignant subcentimeter (≤10 mm) solid pulmonary nodules (SSPNs) from benign ones in computed tomography (CT) images compared against radiologists with 10 and 15 years experience thoracic imaging (medium-senior seniority). Methods: Overall, 200 SSPNs (100 100 malignant) were retrospectively collected. Malignancy was confirmed by pathology, benignity follow-up or pathology. CT...
Non-thermal plasma (NTP) has proven to be an effective approach for the removal of volatile organic compounds (VOCs). However, harmful by-products, produced during NTP-mediated VOCs, hinder practical applications this technology. It is necessary characterize by-products assess their health risks.A method proposed analyzing and evaluating VOCs in work. NTP generated by a coaxial dielectric barrier discharge (DBD) reactor was used model VOC, toluene, nitrogen. Organic products were...
Objective The aim of this study was to investigate the impact pretreatment with transdermal estradiol (E2) compared oral contraceptive pills (OCPs) on controlled ovarian stimulation (COS) response in normal responders undergoing fresh vitro fertilization (IVF)-embryo transfer (ET) cycles. Methods A retrospective cohort performed IVF-ET cycles who received E2 versus OCPs prior IVF-ET. total days stimulation, dosage gonadotropins, number oocytes, and mature oocytes retrieved were noted....
Acupuncture has been clinically used to treat epilepsy after stroke. However, most of the current clinical studies are observational studies, and there few well-designed randomized controlled trials (RCTs). Hence, we designed a multicentre RCT assess advantages efficacy acupuncture for post-stroke (PSE).