A5082528040- Phagocytosis and Immune Regulation
- Iron Metabolism and Disorders
- Erythropoietin and Anemia Treatment
- MicroRNA in disease regulation
- Antimicrobial Resistance in Staphylococcus
- Bacterial biofilms and quorum sensing
- Reproductive System and Pregnancy
- Probiotics and Fermented Foods
- Extracellular vesicles in disease
- Bacterial Identification and Susceptibility Testing
- Antibiotic Resistance in Bacteria
- Ferroptosis and cancer prognosis
- Pharmaceutical and Antibiotic Environmental Impacts
- Antimicrobial agents and applications
- Immune Cell Function and Interaction
- Antibiotic Use and Resistance
- Urinary Tract Infections Management
- Immune cells in cancer
- Infection Control in Healthcare
- Cancer, Hypoxia, and Metabolism
- Microbial bioremediation and biosurfactants
- Vibrio bacteria research studies
- Gut microbiota and health
- Genomics and Phylogenetic Studies
- Microbial Community Ecology and Physiology
Hospital Montecelo
2025
Cornell University
2019-2024
Weill Cornell Medicine
2019-2024
Instituto de Estudios Avanzados
2016
Central University of Venezuela
2011-2012
Abstract Iron accumulation in tumors contributes to disease progression and chemoresistance. Although targeting this process can influence various hallmarks of cancer, the immunomodulatory effects iron chelation tumor microenvironment are unknown. Here, we report that treatment with deferiprone, an FDA-approved chelator, unleashes innate immune responses restrain ovarian cancer. Deferiprone reprogrammed cancer cells toward immunostimulatory state characterized by production type-I IFN...
Urinary tract infections (UTIs) are common and typically treated empirically, based on local antimicrobial resistance (AMR) data, which often scarce in low- middle-income countries. This study examines the AMR patterns of pathogens causing community-onset (CO) UTIs Bolivian Chaco. Urine samples were collected from subjects with suspected CO-UTIs analyzed by culture techniques. Significant isolates tested for their susceptibility. Additionally, blaCTX-M mcr genes searched using real-time PCR....
<p>Table S4 describes the organoids used in this study</p>
<p>Figure S1. (a) Effect of dietary iron levels on ovarian cancer progression. Figure S2. Flow cytometry gating strategy for the analysis peritoneal cells from mice bearing ID8Defb29/Vegfa tumors that were treated with deferiprone as single agent or in combination cisplatin. S3. (a-f) Wild-type female implanted ID8-Defb29/Vegfa and described Fig 2 d. S4. Representative images NKp46 staining entire omentum. S5. MTT assays ID8-Defb29/Vegfa, PPNM, MP different concentrations 12, 24, 48...
<p>Table S3 contains all statistically significant DEGs from RNAseq data</p>
<p>Table S2 contains all the information related to mass spectrometry</p>
<p>Table S5 contains all the primers used in this study</p>
<p>Table S1 describes all the human ascites samples analyzed</p>
Bacterial pathogens have evolved strategies that enable them to invade tissues and spread within the host. Enterococcus faecalis is a leading cause of local disseminated multidrug-resistant hospital infections, but molecular mechanisms used by this non-motile bacterium penetrate surfaces translocate through remain largely unexplored. Here we present experimental evidence indicating E. generates exopolysaccharides containing β-1,6-linked poly-N-acetylglucosamine (polyGlcNAc) as mechanism...
The human gastrointestinal tract (GIT) harbors a diverse microbial ecosystem that plays critical role in defining health and disease.Members of the bacterial genus Enterococcus sp. are common gut-resident microbes have potential to cause life-threatening infections when GIT homeostasis is disrupted due immunosuppression or prolonged antibiotic treatment [1].Enterococcus faecalis faecium, for instance, predominant gut inhabitants accounting majority hospital-acquired enterococcal...
The relationship between Enterococcus faecalis vaginal colonization and urinary tract infections (UTIs) remains uncertain. We aimed to evaluate the surface invasion capability of E isolates from patients with without UTIs as a potential readout pathogenicity. Participants were females urogynecology clinics, comprising symptomatic UTI asymptomatic non-UTI patients, categorized by presence or absence faecalis-positive cultures identified via standard urine culture techniques. Vaginal samples...
Klebsiella pneumoniae is a bacterial pathogen that has developed resistance to multiple antibiotics and major cause of nosocomial infections worldwide. Carbapenemase-producing have been isolated in many hospitals Venezuela, but they not well-studied. The aim this study was characterize carbapenem-resistant isolates from the pediatric service hospital located Anzoategui State, eastern part Venezuela. Nineteen strains April July 2014 were evaluated phenotypically molecularly for presence...
Enterococcus faecalis is a normal commensal of the human gastrointestinal tract (GIT). However, upon disruption gut homeostasis, this nonmotile bacterium can egress from its natural niche and spread to distal organs. While translocation process lead life-threatening systemic infections, underlying mechanisms remain largely unexplored. Our prior work showed that E. migration across diverse surfaces requires formation matrix-covered multicellular aggregates synthesis exopolysaccharides, but...
Enterococcus faecalis is a commensal bacterium that normally inhabits the gastrointestinal tract of humans. This non-motile microorganism can also cause lethal infections in other organs by penetrating and breaching intestinal barrier. However, precise molecular mechanisms enabling E. movement translocation across epithelial barriers remain incompletely characterized. We recently reported utilizes RpiA-GlnA-EpaX metabolic axis to generate β-1,6-linked poly-N-acetylglucosamine...
<div>Abstract<p>Iron accumulation in tumors contributes to disease progression and chemoresistance. Although targeting this process can influence various hallmarks of cancer, the immunomodulatory effects iron chelation tumor microenvironment are unknown. Here, we report that treatment with deferiprone, an FDA-approved chelator, unleashes innate immune responses restrain ovarian cancer. Deferiprone reprogrammed cancer cells toward immunostimulatory state characterized by...
<p>Figure S1. (a) Effect of dietary iron levels on ovarian cancer progression. Figure S2. Flow cytometry gating strategy for the analysis peritoneal cells from mice bearing ID8Defb29/Vegfa tumors that were treated with deferiprone as single agent or in combination cisplatin. S3. (a-f) Wild-type female implanted ID8-Defb29/Vegfa and described Fig 2 d. S4. Representative images NKp46 staining entire omentum. S5. MTT assays ID8-Defb29/Vegfa, PPNM, MP different concentrations 12, 24, 48...
<p>Table S1 describes all the human ascites samples analyzed</p>
<p>Table S2 contains all the information related to mass spectrometry</p>
<p>Table S5 contains all the primers used in this study</p>
<p>Table S3 contains all statistically significant DEGs from RNAseq data</p>
<p>Table S4 describes the organoids used in this study</p>