A5004867828- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Cervical Cancer and HPV Research
- Extracellular vesicles in disease
- Circular RNAs in diseases
- RNA Interference and Gene Delivery
- Molecular Biology Techniques and Applications
- Genomics and Chromatin Dynamics
- T-cell and Retrovirus Studies
- Nuclear Receptors and Signaling
- BRCA gene mutations in cancer
- Virus-based gene therapy research
- Epigenetics and DNA Methylation
- Immunotherapy and Immune Responses
Ministry of Health of the Russian Federation
2022-2024
Ministry of Health
2024
Tomsk National Research Medical Center
2022
Russian Cancer Research Center NN Blokhin
2021
Extracellular vesicles (EVs), including exosomes, are key factors of intercellular communication, performing both local and distant transfers bioactive molecules. The increasingly obvious role EVs in carcinogenesis, similarity molecular signatures with parental cells, precise selection high stability cargo molecules make exosomes a promising source liquid biopsy markers for cancer diagnosis. uterine cavity fluid, unlike blood, urine other body fluids commonly used to study EVs, is origin...
Introduction . Human papillomavirus (HPV) infection with high-risk HPVs is an etiological factor in the development of cervical cancer, HPV type 16 (HPV16) being most common. The mechanisms leading to disruption viral oncogene expression and initiation epithelial cell transformation are poorly understood. Epigenetic regulatory factors, including cellular miRNAs, may play important role HPV-induced carcinogenesis, aberrantly expressed miRNAs be promising markers for diagnosis HPV-associated...
Resistance to hormonal and targeted therapies in breast cancer limits treatment efficacy. Epigenetic alterations, including changes mediated by DNA methyltransferases, play a key role this process. Previously, we identified that resistance tamoxifen rapamycin is associated with the suppression of DNMT3A. This study aims further explore mechanisms underlying suppression, focus on identifying NR6A1 as novel regulatory factor.
BACKGROUND: Cervical cancer (CC) is the fourth most common among women worldwide in terms of incidence and mortality. High-risk human papillomaviruses (HPVs) are etiologic factor CC more than 90% cases, with type 16 HPV (HPV16) revealed 50% cancers. Dysregulation expression viral oncogenes E6 E7 main cause malignant transformation infected cervical epithelial cells. The mechanisms impaired these genes still underexplored. dysfunction microRNAs may be underlying factors. AIM: To analyze...
Introduction. High carcinogenic-risk human papillomaviruses (hrHPVs) are recognized as etiological agents of cervical cancer. Constant expression the viral oncoproteins, E6 and E7, is required for maintenance malignant phenotype tumor cells. The exact mechanism regulation oncogenes in cells not fully elucidated.
 purpose: identification noncoding RNAs (ncRNAs) HPV16-positve cancer.
 Materials methods. reverse transcription polymerase chain reactions were used to detect ncRNAs...
Introduction . Rearrangement of molecular pathways and activation bypass signaling determine the progression tumor cell resistance to various drugs. Study common features resistant formation mechanisms is essential for breast other cancer beneficial treatments. Materials methods The present work was performed on estrogen receptor α ERα-positive (ERα – α) McF-7 cells, established sublines mTOR inhibitor rapamycin or antiestrogen tamoxifen, ERα-negative MDA-MB-231 cells. Methods used include...