A5036787816- Bacteriophages and microbial interactions
- Viral gastroenteritis research and epidemiology
- RNA and protein synthesis mechanisms
- Viral Infectious Diseases and Gene Expression in Insects
- Parvovirus B19 Infection Studies
- Respiratory viral infections research
- Cancer-related molecular mechanisms research
- Molecular Biology Techniques and Applications
- Cervical Cancer and HPV Research
Skolkovo Institute of Science and Technology
2022-2024
University College Cork
2022-2023
APC Microbiome Institute
2022-2023
Ministry of Health of the Russian Federation
2022
Abstract Thermus thermophilus bacteriophage P23-45 encodes a giant 5,002-residue tail tape measure protein (TMP) that defines the length of its extraordinarily long tail. Here, we show N-terminal portion TMP is an unusual RNA polymerase (RNAP) homologous to cellular RNAPs. The TMP-fused virion RNAP transcribes pre-early phage genes, including gene another, non-virion RNAP, early and some middle genes. We report crystal structures both has crab-claw-like architecture. By contrast, adopts...
Introduction. High carcinogenic-risk human papillomaviruses (hrHPVs) are recognized as etiological agents of cervical cancer. Constant expression the viral oncoproteins, E6 and E7, is required for maintenance malignant phenotype tumor cells. The exact mechanism regulation oncogenes in cells not fully elucidated.
 purpose: identification noncoding RNAs (ncRNAs) HPV16-positve cancer.
 Materials methods. reverse transcription polymerase chain reactions were used to detect ncRNAs...
Abstract Thermus thermophilus bacteriophage P23-45 encodes a giant 5,002-residue tail tape measure protein (TMP) 1 that defines the length of its extraordinarily long 800 nm 2,3 . We found N-terminal portion TMP is an unusual RNA polymerase (RNAP) homologous to cellular and viral ‘two-barrel’ RNAPs. The TMP-fused virion RNAP transcribes pre-early phage genes, including gene another, non-virion RNAP, early some middle genes. determined crystal structures both has crab claw-like architecture...
Thermus thermophilus bacteriophage P23-45 encodes a giant 5,002-residue tail tape measure protein (TMP) that defines the length of its extraordinarily long tail. We found N-terminal portion TMP is an unusual RNA polymerase (RNAP) homologous to cellular RNAPs. This virion RNAP transcribes gene encoding another, non-virion RNAP. determined crystal structures both The has crab-claw-like architecture. By contrast, adopts unique flat structure without clamp, which likely reflects requirement for...