A5006250653- Neuroblastoma Research and Treatments
- Human Health and Disease
- Healthcare Systems and Public Health
- Cancer, Hypoxia, and Metabolism
- Cancer therapeutics and mechanisms
- Glioma Diagnosis and Treatment
- Adrenal and Paraganglionic Tumors
- Lung Cancer Research Studies
- Pituitary Gland Disorders and Treatments
- Neurofibromatosis and Schwannoma Cases
- Regional Socio-Economic Development Trends
- Medical and Agricultural Research Studies
- Psychology of Development and Education
- Cell death mechanisms and regulation
- Neuroendocrine Tumor Research Advances
- Psycholinguistics and Behavioral Studies
- Lung Cancer Treatments and Mutations
- Pain Mechanisms and Treatments
- Cancer Mechanisms and Therapy
- CAR-T cell therapy research
- Musculoskeletal pain and rehabilitation
- Tumors and Oncological Cases
- HIV, TB, and STIs Epidemiology
- Reproductive tract infections research
- Vascular Tumors and Angiosarcomas
Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology
2019-2025
Ministry of Health of the Russian Federation
2019-2024
Regional Open Social Institute
2020
Medical University Plovdiv
1998
Neuroblastoma is the most common extracranial solid tumor in children 0–14 years old. Current risk-adapted treatment programs are based on stratification of patient into three risk groups. 40–50% patients stratified high-risk group. The prognosis remains poor (the probability long-term survival less than 50%), despite use aggressive multimodal therapy, including high-dose chemotherapy and autologous hematopoietic stem cell transplantation. In cases cells neuroblastoma express...
Aim. To determin the clinical and biological features of neuroblastoma in patients over 10 years old. Materials methods. Patients with a histologically verified diagnosis / ganglioneuroblastoma established age were retrospectively selected. Molecular genetic tests included fluorescence situ hybridization (FISH), multiplex ligation-dependent amplification (MLPA) targeted next generation sequencing tumor-derived DNA. The described cohort 11 adolescents median 160 months (124–173 months) at 1...
INTRODUCTION: Extracranial neurogenic tumors in children are represented by neoplasms of the sympathetic nervous system and adrenal medulla: ganglioneuromas, ganglioneuroblastomas neuroblastomas. The main prognostic factors used to stratify patients into risk groups and, many ways, determine effectiveness treatment histological type tumor presence MYCN gene amplification. OBJECTIVE: To evaluate capabilities quantitative MRI variant predict amplification children. MATERIALS AND METHODS: We...
The article analyses psychological factors of the formation foreign students’ inter- cultural adaptation at university. authors note importance to consider effectiveness intercultural adaptation, various aspects emotional stability development in students within university educational process, define forms and methods interaction with them process pedagogical support university, as well conditions for implementation ensuring quality indicators professional training conclude that there is a...
Somatic translocations involving the NTRK genes occur in 0.34–2.2% of all malignant neoplasms children. TRK inhibitors whose efficacy has been demonstrated prospective clinical studies expand treatment options for patients with solid tumors harboring gene rearrangements. The aim our study was to summarize first Russian experience use inhibitor entrectinib extracranial fusion-positive included compassionate program. This approved by Independent Ethics Committee and Academic Council Dmitry...
In recent decades, there has been marked progress in understanding the biology of most common extracranial solid tumor childhood – neuroblastoma (NB), which led to a significant improvement treatment outcomes due stratification patients into risk groups, intensification with metastatic disease and presence unfavorable molecular genetic markers. Survivors who have received multimodal therapies, including chemotherapy, high-dose therapy autologous peripheral stem-cell transplantation,...
Neuroblastoma (NB) is the most common extracranial embryonic tumor in children with a variety of molecular biological and clinical characteristics. There no single genetic mechanism involved pathogenesis NB, which determines its heterogeneity. Pathogenetically important event development NB are aberrations ALK gene (Anaplastic lymphoma kinase), found 70 % patients familial form 7– 10 sporadic cases. oncogene encodes receptor same name, expressed on membrane cells central peripheral nervous...
Malignant rhabdoid tumor (MRT) is a rare malignant neoplasm of childhood, characterized by an aggressive course and extremely unfavorable prognosis. The frequency MRT outside the central nervous system (extracranial MRT) 0.02–0.03 per 100,000 children. In most cases, based on inactivating mutations suppressor gene SMARCB1, which leads to absence expression SMARCB1 ((INI1/hSNF5/BAF47) protein in cells. Aberrations SMARCA4 gene, molecular event, have been described among MRTs expressing...
Neuroblastoma (NB) is the most common extracranial solid embryonic tumor in children. The age of patient, prevalence process and molecular genetic profile formed basis risk-adapted therapy protocols. High-risk patients receive complex treatment, including various combinations chemotherapy drugs, surgical removal tumor, radiation radioisotope therapy. Since end 90s last century, immunotherapy has been introduced into clinical practice as a post-consolidation phase with aim affecting minimal...
Introduction . In 1990–2017, the size of population in Belgorod Region increased by 10.9 % only as a result migration. Negative medical and demographic trends characterized decline caused decreased birth rate, mortality disease incidence rates, aging were registered at that time. The level primary disability due to digestive diseases dropped significantly; yet, young middle-aged people grades II III began prevail among cases. Our objective was study regional characteristics situation from...
Bilateral adrenal pheochromocytoma (PCС) is extremely rare in children, with major predisposing factors being multiple endocrine neoplasia type 2 and von Hippel–Lindau syndrome. In case of bilateral PCC underlying syndrome, organ-preserving surgery preferred view the low malignant potential such neoplasms. We aimed to study clinical molecular genetic features patients PCCs treated at Dmitry Rogachev National Medical Research Center Pediatric Hematology, Oncology Immunology, Ministry...
Angiosarcoma is a rare and highly malignant endothelial tumor, which occurs mainly in adults extremely children adolescents. The German guidelines for the treatment of soft tissue sarcomas provided by Cooperative Weichteilsarkom Studiengruppe 2012 included separate therapeutic regimen pediatric angiosarcoma consisting combination vincristine/doxorubicin/cyclophosphamide (VDC) paclitaxel. aim this article was to describe epidemiological, clinical, morphological characteristics angiosarcoma,...
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Insomnia is a common symptom in children with malignant diseases and especially tumors of the central nervous system (CNS). However, little attention paid this complication during therapy neoplasms. violates quality life their immediate surroundings. In article, etiology, pathogenesis, diagnostics are discussed detail, methods for treating pathology presented two clinical cases confirming diverse nature insomnia CNS tumors. Thus, importance an individual approach to emphasized. Conflict...
Appears in: EDULEARN19 Proceedings Publication year: 2019Pages: 10419-10422ISBN: 978-84-09-12031-4ISSN: 2340-1117doi: 10.21125/edulearn.2019.2624Conference name: 11th International Conference on Education and New Learning TechnologiesDates: 1-3 July, 2019Location: Palma, Spain
Sexually transmitted infections are a group of diseases that include syphilis, gonorrhea, chlamydial and mycoplasma infections, trichomoniasis, herpes HPV the genital organs. In addition, sexually human immunodeficiency virus, causing disease called acquired immune deficiency syndrome. According to World Health Organization, every year more than 340 million people aged 15-49 suffer from worldwide. The basis for prevention spread infection with virus should be considered presence internal...
РЕАБИЛИТАЦИЯ ИНВАЛИДОВ ТРУДОСПОСОБНОГО
Bilateral adrenal neuroblastoma (BANB) is a very rare entity. It more common in young children and has certain clinical features. Patients with BANB have favorable prognosis than patients unilateral (NB). The article presents an analysis of 29 cases who underwent treatment at the Dmitry Rogachev National Medical Research Center Pediatric Hematology, Oncology, Immunology. This study supported by Independent Ethics Committee approved Academic Council was performed for period from April 2012 to...