A5007329602- Chromosomal and Genetic Variations
- Plant Genetic and Mutation Studies
- Neuroblastoma Research and Treatments
- Nitrogen and Sulfur Effects on Brassica
- Glioma Diagnosis and Treatment
- Plant Reproductive Biology
- Neurofibromatosis and Schwannoma Cases
- Viral Infections and Immunology Research
- Hedgehog Signaling Pathway Studies
- CRISPR and Genetic Engineering
- Cancer therapeutics and mechanisms
- Genomics and Phylogenetic Studies
- Cancer, Hypoxia, and Metabolism
- Plant tissue culture and regeneration
- Chromatin Remodeling and Cancer
Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology
2023-2024
Engelhardt Institute of Molecular Biology
2014-2017
Treatment of patients with high-risk neuroblastoma (NB) is a complex challenge, and it based on response to certain elements therapy. The development introduction new treatment approaches, such as GD2-targeted immunotherapy (IT), leads improved survival in this cohort patients. aim the study was retrospectively assess effectiveness therapy NB before IT into clinical practice. We analyzed data 151 stratified group who had received accordance modified NB2004 protocol German Society for...
INTRODUCTION: Extracranial neurogenic tumors in children are represented by neoplasms of the sympathetic nervous system and adrenal medulla: ganglioneuromas, ganglioneuroblastomas neuroblastomas. The main prognostic factors used to stratify patients into risk groups and, many ways, determine effectiveness treatment histological type tumor presence MYCN gene amplification. OBJECTIVE: To evaluate capabilities quantitative MRI variant predict amplification children. MATERIALS AND METHODS: We...
SHH group of medulloblastoma is a heterogeneous tumor cohort. The neoplasms differ by biological characteristics as well clinical features and prognosis the disease. Purpose study analysis clinical, molecular genetic for defining in patients with medulloblastoma. 28 medulloblastomas were included study. MB verification was performed parallel Nanostring gene expression profiling immunohistochemical assessment samples. detection TP53 mutations carried out Sanger sequencing. prognostic impact...