A5050174992- Hepatocellular Carcinoma Treatment and Prognosis
- Neuroblastoma Research and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Chromatin Remodeling and Cancer
- Cancer therapeutics and mechanisms
- Childhood Cancer Survivors' Quality of Life
- Organ Transplantation Techniques and Outcomes
- Neuroendocrine Tumor Research Advances
- Renal and related cancers
- Pancreatic and Hepatic Oncology Research
- Ovarian cancer diagnosis and treatment
- Tumors and Oncological Cases
- Genetic and Kidney Cyst Diseases
- Human Health and Disease
- Acute Lymphoblastic Leukemia research
- Lung Cancer Research Studies
- Cancer, Hypoxia, and Metabolism
- Cancer Mechanisms and Therapy
- Effects of Radiation Exposure
- Child and Adolescent Health
- Obesity, Physical Activity, Diet
- Sarcoma Diagnosis and Treatment
- Ukraine: War, Education, Health
- Education and Social Development in Ukraine
- Testicular diseases and treatments
Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology
2014-2024
Ministry of Health of the Russian Federation
2015-2022
Treatment of patients with high-risk neuroblastoma (NB) is a complex challenge, and it based on response to certain elements therapy. The development introduction new treatment approaches, such as GD2-targeted immunotherapy (IT), leads improved survival in this cohort patients. aim the study was retrospectively assess effectiveness therapy NB before IT into clinical practice. We analyzed data 151 stratified group who had received accordance modified NB2004 protocol German Society for...
Стаття присвячена проблемам збільшення захворюваності та поширеності дитячих хвороб протягом 1994–2016 рр. на тлі глобального скорочення кадрового забезпечення дитячими лікарями в 1,7 раза, із вкрай недостатнім забезпеченням областей Південного Сходу, Донецької і Луганської областей. Усе зазначене чинить негативний вплив якість медичного обслуговування дитячого населення, зокрема виявлюваність віку. Автори обґрунтовують необхідність відновлення й матеріально-технічного потенціалу...
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Treatment intensification in patients with intermediateand high-risk neuroblastoma (NB) has led to improved survival rates. However, NB survivors face a high risk of long-term side effects associated intensified therapy, second malignant neoplasms (SMN) being the most serious and occurring 1.2% cases. Our study included 176 cancer who had been treated for at Dmitry Rogachev National Medical Research Center Pediatric Hematology, Oncology Immunology, Ministry Healthcare Russian Federation. The...
The clinical case of a giant congenital germ cell tumor (immature teratoma, 2 grade) soft tissues the head and neck with destruction large wing sphenoid bone, with spreading to oral cavity transition beyond middle line, infiltration tongue, complete obstruction nasopharyngeal child 15 days life. article describes Specific features performing surgical intervention are described taking into account prevalence process. discussed issues teratoma classification, methods diagnosis, provision...
Hepatoblastoma (HB) is the most common malignant liver tumor in children. The level of alpha-fetoprotein (AFP) used for monitoring response to antitumor therapy and diagnosing relapses. occurrence HB relapses with normal AFP levels patients who had elevated this marker at disease onset considered be an uncommon situation. aim study was describe cases which AFP-negative hepatoblastoma developed. participants included two were initially stratified into high-risk standard-risk groups received...
Radical tumor removal remains the key task in hepatoblastoma surgery. Patients who need extended resection and have a risk of posthepatectomy liver failure are particularly difficult. In cases with insufficient future volume, method choice is two-staged hepatectomy or transplantation. Despite wide spread laparoscopic surgery adults, minimally invasive approach has not been studied pediatrics, literature on this issue scarce. current publication case successful partial associating partition...
Modern, risk-adapted treatment approaches for intermediate and high-risk neuroblastoma (NB) have led to an increasing numbers of survivors. However, intensive multimodal strategy is associated with a significantly increased risk secondary malignancies. It currently known that alkylating agents, topoisomerase II inhibitors, platinum compounds induce treatment-related leukemia. This article presents literature review description clinical case acute myeloid leukemia (s-AML) developed 57 months...
Objective To improve the outcomes in children with hepatoblastoma. Material and methods There were 160 focal liver lesions who underwent surgery at department of transplantation 2008-2019. Patients malignant tumors made up 77% (n=123). Hepatoblastoma (HB) prevailed (86%, n=106). Liver was performed 19 (18%) patients HB. Median follow-up after 24.3 months by December 2019. Follow-up period did not exceed 4 years more than 2/3 patients. Results Overall disease-free 10-year survival 87.1%...
Hepatoblastoma (HB) is the most common primary malignant liver tumor in children. Relapses of HB are rare and make up no more than 12% cases among patients who have achieved complete response after first-line therapy. The aim study was to analyze incidence, clinical characteristics outcome relapses treated according SIOPEL protocols. This supported by Independent Ethics Committee approved Academic Council Dmitry Rogachev National Medical Research Center Pediatric Hematology, Oncology,...
Children with malignancies have a high risk of developing inanition for variety reasons associated both tumor and the toxicity performed therapy. Enteral feeding via percutaneous endoscopic gastrostomy (PEG) is one procedures to correction nutritional status. The authors show feasibility safety PEG in children solid malignancies, as well possibility using patients receiving cycles intensive chemoradiation paper analyzes case histories undergoing correct status, indications its application,...
Nutrition status (NS) disturbance registered at majority of patients receiving treatment on malignancies due to both malignant substrate and specific treatment. Due this situation a question actual nutrition group remains actual. This work presents analysis children with solid non-CNS CNS tumors the stage intensive chemotherapy. Significant decreasing protein energy income consumed ration was revealed. can be risk-factor severe disturbance. NC dynamics during our study showed that correction...
Aim. To analyze the short-term outcomes of сentral segments liver resection in children, according to initial experience. Мethods. The data patients with different centrally located neoplasms were analyzed. This retrospective study included three hepatoblastoma, one observation mesenchymal hamartoma and patient hepatocellular carcinoma. Different types central resections carried out these between March October 2018. technical aspects results are described. Results. Median age was 78 months...
Risk-adapted therapy is the standard of care for hepatoblastoma (HB). The aim this study was to analyze effectiveness cisplatin monotherapy in patients with standard-risk HB. approved by Independent Ethics Committee and Scientific Council Dmitry Rogachev National Medical Research Center Pediatric Hematology, Oncology Immunology Ministry Healthcare Russian Federation. For period 02.2012–12.2019 (95 months) 60 HB aged 0–8 years were treated within framework cooperation Federation B.V....