A5085594255- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gallbladder and Bile Duct Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic and Hepatic Oncology Research
- Liver Disease Diagnosis and Treatment
- Parasitic infections in humans and animals
- Congenital Anomalies and Fetal Surgery
- Abdominal Trauma and Injuries
- Amoebic Infections and Treatments
- Biliary and Gastrointestinal Fistulas
- Cancer Research and Treatments
- Renal cell carcinoma treatment
- Gastric Cancer Management and Outcomes
- 3D Printing in Biomedical Research
- Medical Imaging and Pathology Studies
- Cancer Genomics and Diagnostics
- Vascular anomalies and interventions
- Intestinal Malrotation and Obstruction Disorders
- Peptidase Inhibition and Analysis
- Multiple Myeloma Research and Treatments
- Advanced Radiotherapy Techniques
- Growth Hormone and Insulin-like Growth Factors
- Cancer, Hypoxia, and Metabolism
- Neuroblastoma Research and Treatments
Moscow Clinical Scientific Center
2016-2025
Sorbonne Université
2018
Pitié-Salpêtrière Hospital
2018
Institute of Surgery named after A. V. Vishnevskogo
2012-2015
Medical Technologies (Czechia)
2009
Aim . To evaluate the treatment outcomes for patients with true type IV portal cholangiocarcinoma according to Bismuth–Corlette classification. Materials and methods The study involved of 272 2014–2022. tumors were initially diagnosed in 59 patients. Results Upon assessing anatomy bile duct confluence using MRI cholangiography, verified only 22 In other cases, extent tumor process was overestimated due different anatomical configurations confluence. Seven (33%) underwent surgery, R0...
Pancreatoduodenal resection (PDR) is one of the most difficult surgical interventions in abdominal surgery childhood. We present our clinical observation a postoperative complication 14-years-old girl. The girl was operated on for solid pseudopapillary tumor head pancreas, laparoscopically assisted pylori-preserving PDR performed, mobilization and removal distally between stump pancreas Roux-en-Y loop pancreatoejunoanastomo formed. Mechanical jaundice occurred late period. Percutaneous...
Aim. To evaluate the efficacy of laparoscopic interventions and to carry out a comparative analysis various options for biliodigestive anastomoses in children with cystic dilation bile ducts. Materials methods. The results were retrospectively analyzed 110 aged 2 months – 17 years duct dilation. Conversion was required 3 observations (2.7 %). Laparoscopically assisted or total extirpation dilated ducts hepaticojejunostomosis performed 83 patients (75.5 %), surgery hepaticoduodenostomosis 24...
The Russian consensus document on topical issues of the diagnosis and treatment obstructive jaundice syndrome was prepared by a group experts in various fields surgery, endoscopy, interventional radiology, radiological intensive care. goal this is to clarify consolidate opinions national following issues: timing jaundice, features diagnostic measures, need possibility conservative measures for strategy biliary decompression depending cause level block.Российский консенсус (согласительный...
Abstract Background Percutaneous radiofrequency-assisted liver partition with portal vein embolization in staged resection (PRALPPS) represents an alternative to (PVE) followed by major patients perihilar cholangiocarcinoma. Methods This was observational case–control study. Both procedures were applied a future remnant (FLR) volume of less than 40 per cent. The main end points the study short-term morbidity and mortality for two procedures. also compared efficacy preresection phases...
Currently, the strategy for preoperative management of patients with malignant obstructive jaundice is not defined. The indications biliary drainage procedures, choice technique and duration are still disputable. Analysis international trials revealed that routine procedures recommended. in resectable tumors determined considering severity jaundice, cholangitis, dates major surgery Bismuth-Corlette tumor type case proximal stricture. retrograde or antegrade depends on stricture (distal...
Aim. To analyze complications of percutaneous transhepatic cholangiostomy depending on biliary obstruction level and drainage type. Material methods. Percutaneous was carried out in 974 patients with mechanical jaundice different genesis. External predominantly performed for distal obstruction, external-internal suprapapillary – proximal obstruction. Strictures biliodigestive anastomosis were managed using balloon dilatation long-term drainage. Results. Overall morbility 19.1%. Significant...
Aim. To compare different surgical methods for liver failure prevention after major hepatectomies with small future remnant. Material and Methods. For of post-resection failure, variants two-stage procedures were applied in 31 pts The following used: portal vein embolization subsequent hepatectomy (23), ALPPS (1), minimally invasive partial radio-frequency destruction the parenchyma plane resection without separation (RALPPS) (5), right ligation (2). Results. led to hypertrophy rate remnant...
Aim. To determine the indications and to evaluate possibilities of antegrade percutaneous biliary interventions for benign strictures biliary-enteric anastomosis. Material Methods. From 2012 May 2017 sixty five patients with anastomoses were treated. There 48 women 17 men aged 25–82 years. 36 had hepaticoenterostomy, 26 – double hepaticojejunostomy 3 triple hepaticojejunostomy. Antegrade intervention consisted puncture bile duct, recanalization balloon dilatation stricture transhepatic...
Introduction: Radical surgery is the only curative method for liver alveolar echinococcosis (AE).To date, there no information about efficacy of laparoscopy including robot-assisted resection in radical treatment AE.This a case report AE.Case Description: A 51-year-old man was admitted to clinic with complaints weakness and pain right abdomen.Computed tomography (CT) revealed lesion measuring 46 ϫ 52 86 mm, located segments VI VII, those performed.The lasted 485 minutes, intraoperative blood...
To perform a comparative analysis of computerized tomographic volumetry and scintigraphic liver in assessment remnant volume after advanced hepatic resection.Static hepatobiliary scintigraphy CT were performed 45 patients with various tumors who underwent hepatectomies (more than three segments).There no any significant differences volumetric parameters obtained by volumetry.Scintigraphic data are similar to those evaluation future volume. Scintigraphic may be used as an alternative...
The management of biliary decompression in malignant hilar carcinoma remains controversial. This review shows the most relevant aspects endoprosthetics for proximal obstruction, including necessity stenting and morphological verification before radical surgery, selection approach to drain etc. main contradictions ways solve them are presented this article, based on evidence researches, international expert consensus conferences.
The Russian consensus on the treatment of intrahepatic cholangiocarcinoma was prepared by group experts consisting surgeons, interventional radiologists, radiation therapists and oncologists. purposes this are clarification consolidation opinions multidisciplinary team following issues management patients with cholangiocarcinoma: indications for surgical treatment, features therapeutic tactics mechanical jaundice, technical aspects liver resection, prevention post-resection failure,...
Background. Minimally invasive radical surgery for perihilar cholangiocarcinoma is in its early stages. Aim. A comparative analysis of the initial experience robot-assisted and open resections cholangiocarcinoma. Material methods. The single-center experience, accumulated over period from 2014 to 2018, analyzed. Robot-assisted procedures included major liver resection caudate lobectomy with extrahepatic bile duct lymphadenectomy. need vascular reconstruction was considered a contraindication...
Aim: to evaluate the short- and long-term outcomes of laparoscopic open operations in treatment hepatic echinococcosis. Materials methods. The results echinococcectomies performed from 2013 2020 were retrospectively studied. Laparoscopic considered method choice. Open cases with contraindications approach. Results. In total, 57 patients operated: 47 laparoscopically (including robotic approach 4 cases), 9 underwent surgery. Radical procedures prevailed among cystectomies: 46 (98%). groups...
Aim. To determine the character of bile outflow in patients who underwent biliary tract reconstructive surgery without any clinical and instrumental evidence stricture biliodigestive anastomosis. Materials methods. The authors analyzed findings radionuclide studies conducted 102 with anastomosis from 2016 to 2020. significant relationship between data hepatobiliary scintigraphy results was confirmed using Fisher’s exact test. Results. In 75 (73.5%), disturbance attributed efferent loop...
Aim. To analyze radiofrequency ablation per se and in combination with other X-ray surgical procedures patients liver bile ducts malignancies. Material methods. Radiofrequency was used three groups: percutaneous intervention or resection – group 1 (n = 111); combined intra-arterial chemoembolization 3) 2; RFA followed by right portal vein embolization (RALPPES) order to induce hypertrophy enable 3 20). Results. There were no recurrences after ablation. Two-year survival 55% hepatocellular...
Minimally invasive ablative technologies is a promising direction in the treatment of some cancer patients including pancreatic cancer. Cryodestruction, radiofrequency ablation, irreversible electroporation and ultrasound ablation show encouraging results regarding destruction tumor tissue, cytoreduction. These methods are associated with small number complications relatively easy to tolerate by patients. However, there no single approach their use complex these Accumulation data followed...
Abstract Background: Insulin-like growth factor 1 (IGF1) exerts a broad anti-apoptotic function, and IGF1/IGF1-receptor (IGF-1R) signaling pathway plays crucial role in human cancer development progression. Stromal cells associated with are considered an important component of tumor microenvironment, including pancreatic cancers. Previously we have shown increased expression IGF1 ductal adenocarcinoma stroma. The goal our study was to investigate the effect on for progression genes that...