A5033757149- Tuberculosis Research and Epidemiology
- Infectious Diseases and Tuberculosis
- Pneumocystis jirovecii pneumonia detection and treatment
- Diagnosis and treatment of tuberculosis
- Foreign Language Teaching Methods
- Medical and Biological Sciences
- Innovative Educational Technologies
- Pneumonia and Respiratory Infections
- Respiratory and Cough-Related Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Circadian rhythm and melatonin
- Healthcare Systems and Public Health
- Human Health and Disease
- Ukraine: War, Education, Health
- Radiomics and Machine Learning in Medical Imaging
- Mycobacterium research and diagnosis
- Pediatric health and respiratory diseases
- Digestive system and related health
- COVID-19 diagnosis using AI
- Pancreatic function and diabetes
- Asthma and respiratory diseases
- Bacterial Infections and Vaccines
- Obesity, Physical Activity, Diet
- Mental Health Treatment and Access
- Sarcoidosis and Beryllium Toxicity Research
Bogomolets National Medical University
2017-2024
University Hospital of Geneva
2017
University of Geneva
2015-2017
Aim To determine the impact of a functional human islet clock on insulin secretion and gene transcription. Methods Efficient circadian disruption was achieved in pancreatic cells by small interfering RNA ‐mediated knockdown CLOCK . Human secretory function assessed presence or absence stimulated assays, continuous around‐the‐clock monitoring basal secretion. Large‐scale transcription analysis accomplished sequencing, followed quantitative RT‐PCR selected targets. Results Circadian resulted...
Ukraine is among ten countries with the highest burden of multidrug- resistant TB (MDR-TB) worldwide. Treatment success rates for MDR-TB in remain below global as reported by World Health Organization. Few studies have evaluated predictors poor outcomes Ukraine. We conducted a retrospective analysis patients initiated on treatment Kyiv Oblast between January 01, 2012 and March 31st, 2015. defined good cure or completion categorized those who died, failed defaulted. used logistic regression...
Chronic obstructive pulmonary disease (COPD) is one of the most common non-communicable diseases, characterized by chronic respiratory symptoms (dyspnea, cough, sputum production, and/or exacerbations) due to pathological changes in airways (bronchitis, bronchiolitis) alveoli (emphysema), leading persistent, often progressive airflow obstruction. COPD ranks among top three causes mortality worldwide. According estimates World Health Organization, approximately 300 million people live with...
Molecular clocks, operative in pancreatic islet cells, represent an intrinsic mechanism regulating intracellular metabolism and hormone secretion. Glucagon, somatostatin glucagon-like peptide 1 (GLP-1) are essential coordinators of physiology. Here, we assess the synchronizing capacity glucagon, GLP-1 on α- β-cell circadian clocks.Triple transgenic mice, expressing a PER2::luciferase (luc) reporter combined with β-cell-specific fluorescent reporters, were employed. Isolated islets...
Abstract In 2004, we tested all patients with newly diagnosed tuberculosis (TB) for HIV in Kiev City. The results were compared to information from medical records of 2002, when co-infection prevalence was 6.3%. Of 968 TB patients, 98 (10.1%) infected. TB-HIV is increasing, especially injecting drug users.
Background During adolescence, childhood and adult forms of tuberculosis (TB) overlap, resulting in diverse disease manifestations. Knowing which patient characteristics are associated with manifestations may facilitate diagnosis enhance understanding TB pathophysiology. Methods In this cross-sectional study, we included 10–19-year-olds Ukraine's national registry who started treatment between 2015 2018. Using multivariable regression, estimated associations four presentations TB: pleural,...
Improved understanding of the epidemiology and mortality risk factors extrapulmonary tuberculosis (EPTB) may facilitate successful diagnosis management. We analyzed national surveillance data from Ukraine to characterize EPTB subtypes (ie, localized in different anatomic sites). calculated annual reported incidence, stratified by age, sex, human immunodeficiency virus (HIV) status. Using Cox regression, we estimated factors. Between January 2015 November 2018, 14 062 adults/adolescents (≥15...
We reviewed autopsy data from general hospitals in Lviv, Ukraine to understand pediatric mortality due tuberculosis (TB). identified 14 (0.6%) of 2345 autopsied children with unrecognized or untreated TB. More sensitive TB diagnostics for and improved strategies identifying which require evaluation are urgently needed.
Objective — systematic analysis of the results questionnaire and review available scientific databases to summarize achievements highlight complex TB issues in Ukraine.Materials methods. By communicating with doctors different specialties, on specialization-courses, pre¬certification cycles thematic improvement specialty «phthisiology», «pulmonology», «general practice family medicine», «therapy», conducting their questionnaires, we conducted study priorities formulated questions problems...
Стаття присвячена проблемам збільшення захворюваності та поширеності дитячих хвороб протягом 1994–2016 рр. на тлі глобального скорочення кадрового забезпечення дитячими лікарями в 1,7 раза, із вкрай недостатнім забезпеченням областей Південного Сходу, Донецької і Луганської областей. Усе зазначене чинить негативний вплив якість медичного обслуговування дитячого населення, зокрема виявлюваність віку. Автори обґрунтовують необхідність відновлення й матеріально-технічного потенціалу...
Objective — to study in detail the mechanisms and investigate imaging manifestations of combat-related penetrating thoracic injuries.
 Materials methods. To perform work, a literature search was provided according criterion «Thoracic trauma». 32 literary sources were selected for this request. Fragments clinical experience described illustrated by our own cases patients who treated Kharkiv medical institutions 2022 Results discussion. Among victims received chest injuries, polytrauma...
The university is responsible for creating an academic environment where teaching and research can develop harmoniously optimally. This requires replacing the traditional static concept of medical education with a dynamic one. In carrying out such reform, one important components evolution electronic resource, Internet technologies, online learning information platforms.Objective — to investigate world experience in introduction distance education.Materials methods. Educational e-resources...
<ns4:p><ns4:bold>Background</ns4:bold>: Ukraine has high rates of poor treatment outcomes among drug sensitive tuberculosis (DSTB) patients, while global success for DSTB remain high. </ns4:p><ns4:p> We evaluated baseline patient factors as predictors outcomes.</ns4:p><ns4:p> <ns4:bold>Methods</ns4:bold>: conducted a retrospective analysis new pulmonary TB patients treated in Kyiv Oblast, between November 2012 and October 2014. defined good cure or completion death, default failure....
Приведено состояние разработки и производства отечественных рентгенотелевизионных систем серии «Полискан», которые предназначены для таможенного контроля различных объектов, поступающей корреспонденции предприятий, учреждений организаций, личных вещей
Background: Drug-resistant tuberculosis can emerge during treatment. However, the risk of resistance emergence and its relationship with incomplete treatment (<6 months treatment) are not well understood.Methods: We used surveillance data from Ukraine, January 2015 – November 2018, to identify a cohort people initially diagnosed rifampin-susceptible outcomes lost follow-up (LTFU) or successful did two log binomial regressions estimate association between length and: (1) recurrence (i.e....
The problem of secondary prevention multifocal atherosclerosis (MAS) combined with chronic obstructive pulmonary disease (COPD), is a leading cause death in the world. Therefore, search for drugs capable affecting destructive mechanisms underlying both MAS and COPD an extremely urgent today. Objective — to reduce risks destabilization atherosclerotic plaques by reducing levels metallomatrix metalloproteases (MMP)-2 MMP-9 patients on COPD. Materials methods. study included 62 men (68.1 ± 4.2)...
<sec><title>BACKGROUND</title>We assessed the impact of COVID-19 pandemic on TB notifications in Ukraine, stratified by multiple subgroups.</sec><sec><title>DESIGN/METHODS</title>We analyzed data from Ukraine’s National Program January 2015 to December 2020 using interrupted time series models. We compared observed cases counterfactual estimated had not occurred and trends through nationally various demographics. proportions individuals who underwent...
Few reports have described pediatric Multidrug-resistant Tuberculosis (MDR-TB) in the former Soviet republics, despite fact that these countries highest proportion of TB cases are MDR.We aimed to examine MDR-TB Ukraine.This retrospective cohort study included all children <18 years age who started undergoing treatment between January 1, 2011 and July 31, 2016 at Kyiv City Pediatric Hospital.From each child's clinical chart, we abstracted demographic data.Using Fisher's exact test, compared...
Pulmonary rehabilitation is an interdisciplinary program of care for patients with chronic respiratory disorders, created individually and aimed at physical social indicators autonomy optimizing. Physical therapists in palliative team are key to the success pulmonary patients, focusing on functioning.Objective — review data from literature references regarding characteristics usage frequency diseases who require hospice care, specify which currently used. As a result review, it was...
Lung cancer holds a prominent position in the malignant mortality rates. Despite rapid advancement of pharmacological approaches to lung malignancy treatment, surgical interventions remain relevant and pertinent contemporary practice. The choice an appropriate therapy for local presents particularly acute dilemma. This issue gives rise contradictions as it necessitates tailored approach each individual case. In such instances, only radical treatment methods involve interventions, namely...
Objective — evaluation of the situation with common diseases broncho-pulmonary system and analysis prospects for establishment COPD control from point view present.Used access to various full-text abstract databases.Results discussion. An recent scientific sources has shown, that current problem present is a progressive increase in incidence COPD.Conclusions. major challenge public health significant respiratory medicine, but it can both be prevented treated. through formation systemic...
The transformation of the teaching methodology in European universities is connected with increase proportion self-study according to method consultative-individual form involving platform simulation center, which one conditions for introduction fundamental educational principle continuous education throughout life modern realities globalization and into postindustrial environment.Information communication technologies (ICT) develop ideas programmed learning, provide completely new...
Objective — assessment of the prevalence and incidence bronchial asthma (BA) analysis prospects for establishing disease control in light new clinical guidelines GINA 2019.Materials methods. We used various full-text abstract databases.Results discussion. In Ukraine, according to official statistics 2017, BA was 501.9 patients per 100 thousand adults, which, its part, represents only 0.3 % total population contradicts real world statistics. According experts, Ukraine can reach 7—8 %. recent...