Objective — to study the features of pathomorphosis tuberculous meningitis and central nervous system (CNS) on basis analysis sectional material for 55 years (1948—1998 2020—2024). Materials methods. 179 autopsy protocols were analyzed patients who died in Lviv Region from tuberculosis meninges CNS years. The studied divided into 6 periods: 1st 1948—1957, 2nd 1958—1967, 3rd 1968—1977, 4th 1978—1987, 5th 1988—1998, 6th 2020—2024. Results discussion. Our studies have shown that over past there...

OBJECTIVE. To study the course of HIV/AIDS-associated pulmonary tuberculosis (PTB) depending on sensitivity Mycobacterium (MBT) strains. MATERIALS AND METHODS. 103 medical files patients with co-infection HIV/AIDS/TB for period 2020-2024 were analyzed. Patients divided into two groups: 1st group – 42 HIV/AIDS/TB, who isolated sensitive strains MBT to antimycobacterial drugs (AMBD); 2nd 61 resistant MBT. Microbiological included: detection in sputum by smear microscopy, seeding Lewenstein...

Objective — systematic analysis of the results questionnaire and review available scientific databases to summarize achievements highlight complex TB issues in Ukraine.Materials methods. By communicating with doctors different specialties, on specializa­tion-courses, pre¬certification cycles thematic improvement specialty «phthisiology», «pulmonology», «general practice family medicine», «therapy», conducting their questionnaires, we conducted study priorities formulated questions problems...

Abstract Pediatric tuberculosis is a health problem of special significance because it marker for current transmission in society. The research aimed at analyzing the peculiarities detection and course pediatric extrapulmonary (EPTB) taking into account profile drug resistance. A retrospective study medical charts children with EPTB (n = 47; 1 st group) pulmonary (PTB) 49; 2 nd aged 0-15 2013-2020 has been conducted. subgroups were identified separately: resistant (EPRTB) 23) sensitive...

Анотація. В сучасних умовах клінічний перебіг туберкульозу легень часто проявляється розвитком специфічного процесу на тлі хронічного бронхіту, що характеризується проявом симптомів обох захворювань, ускладнюючи своєчасну діагностику туберкульозу, в зв'язку з чим проблема співвідношення цих двох захворювань вимагає поглибленого вивчення. роботі наведено напрацювання критеріїв клініко-інструментального та лабораторного алгоритму діагностики легенів у поєднанні хронічним бронхітом. Обстежено...

Objective — to study the frequency and causes of diagnostic errors in primary pulmonary tuberculosis (PrPTB) adults. Materials methods. The verifying PrPTB adults were studied by analyzing pathomorphosis aspect a specific process. Sectional material from 200 adult deaths due forms (PrFTB) over period 45 years (1974—2020) was analyzed. divided into three periods: first spanned 1974 1988, during which antimycobacterial drugs (isoniazid, streptomycin, PASC) used; second ranged 1989 2005,...

The aim of the study - to feasibility using natural immunomodulator BIVEL (conditionally called BI-V) as a nonspecific immunoprevention tuberculosis (TB) among contacted children from focies chemodrug-resistant infection on basis clinical and immunological researches. Research metods. object was 120 multidrug-resistant (FsMDR-TBI) including 75 45 adolescents. first contact group included 95 children/adolescents who did not receive BI-V second one ‒ 25 infected received BI-V. Immunological...

BACKGROUND. There is a significant decrease the effectiveness of antituberculous (anti-TB) treatment on background multidrug and extensive drug resistance (MDR/XDR) Mycobacterium tuberculosis. Therefore, in order to increase MDR-/XDR-TB new antimycobacterial drugs such as bedaquiline (Bdq), delamanid (Dlm) pretomanid have been introduced both for adults, children adolescents recent years. MATERIALS AND METHODS. On basis retrospective cohort analysis data patients' medical records evaluation...

Aim - to study the feasibility of using natural immunomodulator BIVEL (BI-V) as a non-specific immunoprevention tuberculosis (TB) among contact children from focies multidrug-resistant infection (FsMDR-TBI) on basis clinical and immunological studies. Materials methods. The object study: 120 contacted FsMDR-TBI (75 45 adolescents). Group 1 95 children/adolescents who did not receive BI-V 2 25 patients received BI-V. state phagocytic reactivity immunity; cellular humoral interleukins specific...

Tuberculosis (TB) is the most frequent opportunistic infection among HIV-positive patients in all countries of world. The spread TB/HIV epidemic an objective threat on a national scale and continues to negatively affect working reproductive potentials population many Objective — analyze clinical diagnostic manifestations tuberculous meningoencephalitis with HIV infection. Materials methods. We analyzed medical data who were hospital for specific process at Lviv Regional Anti-TB Center from...

Objective — to study the need of using natural immunomodulator ВІ-V for contact children and adolescents from focies multidrug-resistant tuberculous infection (MDR-TBI) a non-specific immunoprevention tuberculosis (TB). Materials methods. A retrospective analysis medical records 120 contacts (75 45 adolescents) MDR-TBI 102 adult with TB, who became source was carried out. Microbiological examination in adults included detection Mycobacterium (MBT) sputum by smear microscopy, sowing material...

The spread of respiratory diseases has become a topical issue modern medicine. prevalence the caused rising rates disability and mortality among people affected by diseases. clinical course includes disorders general local adaptive protective mechanisms cell-mediated connections. Objective — to determine interleukin profile serum bronchoalveolar lavage for verification chronic obstructive pulmonary disease (COPD) or bronchial asthma in patients with tuberculosis pneumonia obstruction...

BACKGROUND. Research results in patients with multidrug-resistant pulmonary tuberculosis (MDR-TB) the dynamics of treatment. OBJECTIVE. To study main causes chemotherapy inefficiency MDR-TB. MATERIALS AND METHODS. Comprehensive examination 176 MDR-TB, which was divided into two groups: new cases disease (95 patients) and repeated (81 patients). RESULTS. The has shown that following prognostic criteria are at high risk for development MDR-TB: history anti-tuberculosis treatment, common...

Objective — to examine the tendencies of epidemiological situation on tuberculosis in Ukraine at beginning COVID-19 pandemic 2020. 
 Materials and methods. The analysis data official statistics 2015—2020, a survey 157 medical experts telephone questionnaire 69 residents Volyn region.
 Results discussion. It was established that disease has found its imprint functioning TB care service. In 2020, rate decline incidence pulmonary extrapulmonary significantly more intensive than...

РезюмеЦель исследования: изучить целесообразность назначения иммуномодулятора мурамилпептидного ряда у больных мультирезистентным туберкулезом (МРТБ) на основании клинических, рентгенотомографических и общепринятых лабораторных исследований.Материалы методы.Обследовано 47 больных.В качестве патогенетического препарата был использован иммуномодулятор ряда.Больные были распределены две группы: 1 группу составили 22 пациента, которые получали только противотуберкулезные препараты (ПТП); 2 -25...

Pediatric tuberculosis (TB) is a serious infectious disease that affects many children worldwide and more likely to be extrapulmonary than adult TB. The purpose - analyze the profile of drug resistance Mycobacterium clinical features resistant (EPR) TB among from Lviv region, Ukraine. Materials methods. We analyzed all cases EPR (n=23) sensitive (EPS) (n=24) 478 medical charts children, who were hospitalized in Anti-TB hospital during 2013-2020. Results. It was found out diagnosed...

Objective — to analyze the peculiarities of detection and course various clinical forms extrapulmo­nary tuberculosis (EPTB), profile drug resistance Mycobacterium (MBT) among children different ages.
 Materials methods. We retrospectively analyzed medical data 47 aged 0 14 with local EPTB, hospitalized in pediatric department Lviv TB hospital from 2013 2020. Children were divided into groups: up 1-year-olds (19 children; group I), 2—9 year-olds II) 10—14-year-olds (9 III).
 Results...

Introduction. Against the backdrop of multiple and widespread drug resistance Mycobacterium tuberculosis (MDR-TB), there has been a significant decline in effectiveness treatment (TB) patients Ukraine globally. Therefore, recent years, new antimycobacterial drugs, such as bedaquiline (Bdq), delamanid (Dlm) pretomanid, have introduced to improve efficacy adults, children adolescents. The purpose - study complex with (Bdq) under 18 years old extensively drug-resistant pulmonary TB...

Immunological methods are important for diagnosing tuberculosis, evaluating the process activity, and forecasting course of disease recovery.
 Materials methods. 47 patients with first diagnosed destructive sputum smear-positive pulmonary tuberculosis underwent a complex immunoassay. The were divided into two groups based on sensitivity/resistance mycobacterium to antimycobacterial agents. group consisted 22 first-diagnosed chemosensitive preserved sensitivity second 25 multi-drug...