A5090469089- Tuberculosis Research and Epidemiology
- Pneumocystis jirovecii pneumonia detection and treatment
- Pneumonia and Respiratory Infections
- Mycobacterium research and diagnosis
- Diagnosis and treatment of tuberculosis
- COVID-19 epidemiological studies
- Viral-associated cancers and disorders
- Data-Driven Disease Surveillance
- COVID-19 and healthcare impacts
- Infectious Diseases and Tuberculosis
- Lymphoma Diagnosis and Treatment
- Medication Adherence and Compliance
- HIV/AIDS Research and Interventions
- COVID-19 and Mental Health
- HIV/AIDS drug development and treatment
- Homelessness and Social Issues
- Ubiquitin and proteasome pathways
- COVID-19 Clinical Research Studies
- Bipolar Disorder and Treatment
- Pharmacovigilance and Adverse Drug Reactions
- Mental Health and Patient Involvement
- Climate Change and Health Impacts
- Chronic Disease Management Strategies
- Eosinophilic Disorders and Syndromes
- Bacterial Identification and Susceptibility Testing
London School of Hygiene & Tropical Medicine
2023-2024
University of Edinburgh
2018-2023
Institute of Population and Public Health
2021
University College London
2012-2020
Mortimer Market Centre
2016-2019
Centre for Global Health Research
2019
George Institute for Global Health
2017
European Centre for Disease Prevention and Control
2017
National Health Service
2014-2017
Public Health England
2013-2017
Abstract Reports of ChAdOx1 vaccine–associated thrombocytopenia and vascular adverse events have led to some countries restricting its use. Using a national prospective cohort, we estimated associations between exposure first-dose or BNT162b2 vaccination hematological using nested incident-matched case-control study confirmatory self-controlled case series (SCCS) analysis. An association was found idiopathic thrombocytopenic purpura (ITP) (0–27 d after vaccination; adjusted rate ratio (aRR)...
The US2 and US11 gene products of human cytomegalovirus promote viral evasion by hijacking the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway. initiate dislocation newly translocated major histocompatibility complex class I (MHC I) from ER to cytosol for proteasome-mediated degradation, thereby decreasing cell surface MHC I. Despite being instrumental in elucidating mammalian ERAD pathway, responsible E3 ligase or ligases remain unknown. Using a functional small interfering...
Following the outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus and subsequent global spread 2019 novel disease (COVID-19), health systems populations who use them have faced unprecedented challenges. We aimed to measure impact COVID-19 on uptake hospital-based care at a national level.The study period (weeks ending 5 January 28 June 2020) encompassed pandemic announcement by World Health Organization initiation UK lockdown. undertook an interrupted time-series...
Significance Newly synthesized proteins undergo a strict quality-control checkpoint, and misfolded secretory are targeted across the endoplasmic reticulum membrane back to cytosol for proteasome degradation. This process requires tagging errant with ubiquitin by an E3 ligase. In genetic screen we identified TMEM129 as novel unusual is hijacked human cytomegalovirus degrade MHC-I signaling molecules avert immune recognition of infected cell. We suggest important ligase in turnover within...
The downregulation of cell surface receptors by endocytosis is a fundamental requirement for the termination signalling responses and ubiquitination critical regulatory step in receptor regulation. K5 gene product Kaposi's sarcoma-associated herpesvirus an E3 ligase that ubiquitinates downregulates several immunoreceptors, including major histocompatibility complex (MHC) class I molecules. Here, we show targets membrane proximal lysine MHC conjugation with mixed linkage polyubiquitin chains....
Following the emergence of novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in December 2019 and ensuing COVID-19 pandemic, population-level surveillance rapid assessment effectiveness existing or new therapeutic preventive interventions are required to ensure that targeted those at highest risk serious illness death from COVID-19. We aim repurpose expand an pandemic reporting platform determine attack rate SARS-CoV-2, uptake any vaccine (once available) protective effect...
Peer support can enable patient engagement with healthcare services, particularly for marginalised populations. In this randomised controlled trial, the efficacy of a peer intervention at promoting successful clinical services chronic hepatitis C was assessed. London, UK, potential participants were approached through outreach problematic drug use and homelessness. Individuals positive virus (HCV) after confirmatory testing using an online service to (peer support) or standard care. The...
Testing programs for COVID-19 depend on the voluntary actions of members public their success. Understanding people’s knowledge, attitudes, and behavior related to testing is, therefore, key design effective worldwide. This paper reports findings a rapid scoping review map extent, characteristics, scope social science research identifies themes from literature. Main include discoveries that people are largely accepting technologies guidelines sense solidarity is motivator uptake. The main...
Why was the cohort set up?In December 2019, a novel coronavirus COVID-19 emerged from Wuhan, China, and soon declared as pandemic by World Health Organization (WHO) on 11 March 2020. 1 The UK followed suit implemented national lockdown 23 2020.][5][6][7][8][9] rapid generation of robust data is crucial to monitor, understand mitigate effects COVID-19.The Early Pandemic Evaluation Enhanced Surveillance (EAVE II) database creates national, realtime prospective using Scotland's health...
<b>Objective</b> To assess the cost effectiveness of Find and Treat service for diagnosing managing hard to reach individuals with active tuberculosis. <b>Design</b> Economic evaluation using a discrete, multiple age cohort, compartmental model treated untreated cases <b>Setting</b> London, United Kingdom. <b>Population</b> Hard pulmonary tuberculosis screened or managed by (48 mobile screening unit cases, 188 referred case management support, 180 loss follow-up), 252 passively presenting...
Mobile digital chest radiography (CXR) is used routinely to screen for pulmonary tuberculosis (PTB) in London among homeless populations, persons accessing drug treatment services and prisoners.1) To establish the sensitivity specificity of mobile CXR, 2) test hypothesis that actively identified cases have reduced odds sputum smear positivity vs. those presenting passively health care from same populations.Sensitivity were calculated using a gold standard comparator culture-confirmed PTB...
Uptake of healthcare among migrants is a complex and controversial topic; there are multiple recognised barriers to accessing primary care. Delays in presentation services may result greater burden on costly emergency care, as well increased public health risks. This study aimed explore some the factors influencing registration new entrants with general practitioners (GPs).Retrospective cohort study.Port screening at Heathrow Gatwick airports, care.252 559 UK, whose entry was documented by...