A5069584390- Renal Transplantation Outcomes and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Organ Transplantation Techniques and Outcomes
- Cardiac Imaging and Diagnostics
- Cardiac Structural Anomalies and Repair
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Cardiac Arrhythmias and Treatments
- Gut microbiota and health
- Blood transfusion and management
- Diet and metabolism studies
- Cardiomyopathy and Myosin Studies
- Renal Diseases and Glomerulopathies
- Heart Failure Treatment and Management
- Cardiac and Coronary Surgery Techniques
- Organ Donation and Transplantation
- Chemotherapy-induced cardiotoxicity and mitigation
- Organ and Tissue Transplantation Research
- Anesthesia and Neurotoxicity Research
- Intensive Care Unit Cognitive Disorders
- Cytomegalovirus and herpesvirus research
- Cardiac Ischemia and Reperfusion
- Heparin-Induced Thrombocytopenia and Thrombosis
- Galectins and Cancer Biology
- Teratomas and Epidermoid Cysts
- Takotsubo Cardiomyopathy and Associated Phenomena
Russian Scientific Center of Surgery
2015-2024
Kemerovo Cardiology Center
2024
Sechenov University
2022
Abstract Ischemia‐reperfusion injury has multiple effects on a transplanted allograft, including delayed or impaired graft function, compromised long‐term survival, and an association with increased incidence of rejection. Eculizumab, monoclonal antibody blocking terminal complement activation, been postulated to be effective agent in the prevention amelioration IRI . We performed single‐center prospective, randomized controlled trial involving 57 pediatric kidney transplant recipients...
Background.The leading causes of mortality in the elderly population around world remain cardiovascular diseases, malignant tumors abdominal cavity and pelvic organs, requiring extensive reconstructive surgery.Aim -to assess safety surgical interventions cancer patients with concomitant pathology.Material methods.52 under age 65 (28 men 24 women) underwent various types treatment for colorectal cancer, stomach esophageal hepatocellular liver metastases, pancreatic bile duct uterine ovarian...
Abstract Recipient lymphocytes are crucial for direct and indirect pathways of allorecognition. We proposed that the administration alemtuzumab several weeks pretransplantation could eradicate peripheral lymphatic cells promote donor‐specific acceptance. This was a single‐center, retrospective review 101 consecutive living donor kidney transplantations in pediatric patients (age 7 months—18 years), performed between September 2006 April 2010. IS protocol included two 30 mg doses alemtuzumab:...
To date, the etiological causes of adverse outcomes associated with cardiovascular diseases and concomitant colorectal cancer in one patient, especially over 60 years age, are multifactorial: from undiagnosed timely above-mentioned pathological conditions to poor adherence treatment. It is a multi-level approach that future guarantee reducing burden on public health as result these most common nosologies. The aim work evaluate discussions between different experts an analysis fundamental...
The objective was to demonstrate a clinical case of effective treatment patient with invasive mycosis caused by Candida auris drug resistance antifungal drugs combination micafungin and amphotericin B lipid complex. Materials methods . International databases such as MEDLINE, EMBASE, Web Science Scopus until 2023 were used for the analysis. Results We have demonstrated candidiasis polyresistent pathogen in who underwent mitral valve replacement, which complicated acute aortic dissection,...
Modern clinical practice requires obligatory use of results laboratory researches, international experience demonstrates the need clinic in information for making up to 70% medical decisions. Described a large number biomarkers cardiovascular diseases, high diagnostic efficiency with sufficient level evidence is shown not all. In article possibilities modern determining markers myocardium damage (troponins, hFABP), myocardial stress (natriuretic peptides) and neurohumoral regulation...
To define the effect of donor and recipient gender on results kidney transplantation from living related donor.Group 271 patients who underwent was analyzed. There were 115 women 156 men. Age varied 1 to 63 years (mean 21.30±12.32). 127 children aged 1-18 11.28±4.63) 144 adults 19-63 29.81±11.24). Donors included 162 109 Overall survival calculated using Kaplan-Mayer. Mortality incidence transplants failure determined Fisher's exact test.All divided into 2 groups depending recipients' then 4...
<h3>ЦЕЛЬ ИССЛЕДОВАНИЯ</h3> Определить предикторы безопасности протокола ускоренного восстановления после операций у пожилых пациентов онкологического профиля с коморбидной хронической сердечной недостаточностью (ХСН) и сохранной фракцией выброса левого желудочка (ФВ ЛЖ). <h3>МАТЕРИАЛ И МЕТОДЫ</h3> С января 2018 г. по июль 2020 в ФГБНУ «РНЦХ им. акад. Б.В. Петровского» выполнены радикальные хирургические вмешательства поводу злокачественных новообразований органов брюшной полости малого таза...
Peri-operative bleeding in surgeries with cardiopulmonary bypass results the increase of post-operative complications and mortality. Fibrinolysis hyperactivation is common cause non-operative bleeding. Materials methods. 60 patients who had cardiac surgery were enrolled into study. The antifibrinolytic agent (tranexamic acid) was administered to all patients: 32 (TA1) received an intravenous loading dose tranexamic acid basing on 15 mg/kg during 20 min. consequent infusion 1 mg/(kg × h -1 )...
Objective To improve the outcomes in children with hepatoblastoma. Material and methods There were 160 focal liver lesions who underwent surgery at department of transplantation 2008-2019. Patients malignant tumors made up 77% (n=123). Hepatoblastoma (HB) prevailed (86%, n=106). Liver was performed 19 (18%) patients HB. Median follow-up after 24.3 months by December 2019. Follow-up period did not exceed 4 years more than 2/3 patients. Results Overall disease-free 10-year survival 87.1%...
Aim . To evaluate informativity and relation of changes galectin-3 (G3) natriuretic brain peptide (BNP) in diagnostics myocardium dysfunctions during analysis surgical intervention HCMP patients. Material methods An is presented, 30 patients with diffusegeneralized type hypertrophic cardiomyopathy (HCMP) (16 females 14 males, mean age 53,7±2,8 y. o.), who the time from 2009 to may 2016 V. B. Petrovskiy Russian National Research Centre Surgery, underwent operation extended myectomy. Before...
The aim of investigation is analysis factors forecasting the results kidney transplantation from living-related donors. This research based on 272 kidneys' It was analyzed such parameters as recipients' age, donors' sex, degree relationship between donor and recipient, HLA-compatibility, type inductive immunosuppression (monoclonal antibodies, corticosteroids, polyclonal antibodies), recipient's presence or absence rejection episodes for whole postoperative period. We recognized that far not...
The aim of the study was to determine changes in levels various neurotransmitters depending on depth propofol-induced sedation. Material and methods. Twenty-four patients were included a prospective, simple blinded study. All underwent elective orthopedic intervention with subarachnoid anesthesia moderate (group 1, n =12) or deep 2, Peripheral blood sampling for measurement neurotransmitter performed before regional blockade (Stage 1), 35–40 min after start sedation 2), 10–15 terminated...
First time, myocardial clefty were described more than 20 years ago in autopsy of patients with hypertrophic cardiomyopathy (HCMP): the “fissure” along muscle fibers interventricular septum. Currently, precise diagnostical and practical value this pathology unknown. What sort diagnostic impact such information brings into management evaluation patients? Previously, we reported on unexpected finding fissure together Barlow syndrome. This article continues analysis experience clinical work...
Aim . To evaluate the efficacy of action calcium sensitizer levosimendan (LS) in patients with various grade heart failure (HF) severity before cardiosurgery. Material and methods. LS was applied as a part HF treatment while preparing for surgery 2-4 days. Performed dose 0,025 — 0,1 µg/kg/min. The drug not administered bolus. Preoperation group participants included 108 (62% men, 38% women, aged 20 72 years (53±13)) CHF III-IV FC by NYHA, ejection fraction left ventricle (LVEF) about average...
КЛИНИЧЕСКАЯ И ЭКСПЕРИМЕНТАЛЬНАЯ ХИРУРГИЯ■ КРАТКИЕ СООБЩЕНИЯ Цель -продемонстрировать редкий случай пресакрально расположенной доброкачественной нейрогенной опухоли, предоперационно расцененной как местный рецидив колоректального рака, у пациента с прогрессией заболевания на фоне кардиотоксических эффектов проведенного химиотерапевтического лечения.Основные положения.Пациент, ранее перенесший переднюю резекцию прямой кишки из-за рака верхнеампулярного отдела, проходил химиотерапевтическое...