A5075200215- Ocular Oncology and Treatments
- DNA and Nucleic Acid Chemistry
- Mitochondrial Function and Pathology
- Intraocular Surgery and Lenses
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- ATP Synthase and ATPases Research
- Regional Socio-Economic Development Trends
- Ocular Infections and Treatments
- Blood transfusion and management
- Magnetic and Electromagnetic Effects
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Metabolism and Genetic Disorders
- Viral-associated cancers and disorders
- Muscle and Compartmental Disorders
- Polyomavirus and related diseases
- Cardiac, Anesthesia and Surgical Outcomes
- Legal and Regulatory Analysis
- Brain Metastases and Treatment
- Mining and Gasification Technologies
- Supramolecular Self-Assembly in Materials
- RNA Research and Splicing
- Neuroscience and Neuropharmacology Research
- Coal Combustion and Slurry Processing
- Dental Anxiety and Anesthesia Techniques
Russian Cancer Research Center NN Blokhin
2024
Pirogov Russian National Research Medical University
2011-2023
Semenov Institute of Chemical Physics
2004-2023
Ministry of Health of the Russian Federation
2019-2023
Ministry of Health
2021-2023
Scientific and Production Association. S.A. Lavochkin
2019
Zaporizhia State Medical and Pharmaceutical University
2001
Sechenov University
1983
The rate of a chemical reaction can be sensitive to the isotope composition reactants, which provides also for sensitivity such "spin-sensitive" reactions external magnetic field. Here we demonstrate effect field on enzymatic DNA synthesis together with spin-bearing magnesium ions ([Formula: see text]Mg). monotonously decreased induction increasing in presence zero-spin On contrary, ions, dependence was non-monotonous and possess distinct minimum at 80-100 mT. To describe observed effect,...
We have performed our study on a NEN-treated RB cell culture derived from real clinical autopsy material.3.5year-old male donor has died of massive complex abdominal trauma being previously RB-diagnosed with NMR and ultrasound tests, tumor located behind the eye globe equator line.This is first report ever magnetic isotope effects metal ions to cause clear anti-cancer consequences in retinoblastoma cells by depriving them DNA repair capabilities.Both molecular mechanism phenomenon its...
Human retinoblastoma cells were proven to possess some very unusual DNApolβ species. Being 23.5 kDa monomers, which itself is not common for the superfamily members, these chromatin associated proteins manifests most of DNApolβ-specifc functional peculiarities making them legitimate targets DNA repair cytostatic inhibitors. Particularly, tumor specific enzymes found be sensitive 25Mg2+-, 43Ca2+- and 67Zn2+-promoted magnetic isotope effects (MIE) caused a marked sequence growth limitation as...
Целью статьи является рассмотрение механизмов государственного регулирования рынка жилищного строительства в России и предложение рекомендаций по их совершенствованию. Актуальность выбранной темы обусловлена рядом экономических, социальных институциональных факторов, которые играют ключевую роль развитии строительного сектора. В процессе достижения поставленной цели автором рассматриваются ключевые механизмы российского строительства, такие как финансовая поддержка через льготные ипотечные...
Abstract The self‐assembly of small and always chiral molecules into fiber‐like structures is a mysterious process, as the physics underlying such unclear. energy necessary for this process exceeds one provided by common dispersion interactions hydrogen bonding. recent results obtained scientific group Prof. Naaman from Weizmann Institute Science fed light on nature forces providing attributed these to spin‐exchange interactions. Therefore, should be magneto‐sensitive. We found sensitivity...
Thio- and cyano- modified single-stranded poly(dNTP) sequences of different molecular sizes (20–200 n) the same lengths routine poly(NTP) species were tested for their impact on catalytic activities β-like DNA polymerases from chromatin HL-60, WERI-1A Y-79 cells as well affinity patterns in DNApolβ-poly(dNTP)/(NTP) pairs, respectively. An essential link between ultrashort (50–100 structures inhibitory effects towards cancer-specific β was found. A possible significance this phenomenon both...
A significant population of ultrashort (50-150n) single-stranded DNA fragments were found in exosome-free blood plasma retinoblastoma patients (6.84 ng mL-1), but not healthy donors. An original high resolution HPLC technique has been proposed to reveal and characterize this peculiarity. To solve task, a novel molecular size exclusion - anion exchange analytical was developed. Its applicability diagnostics oncogenesis research is quizzed here.
A (25)Mg(2+)-operated hyper-activation of ATP synthesis has been investigated in mitochondria (Mt) isolated from iron-rich and iron-poor rat tissues: spleen, liver, skeletal muscle, myocardium, kidneys, brain. Both magnetic ((25)Mg) non-magnetic ((24)Mg) magnesium isotopes were separately administered to estimate the degree production related isotope effect (MIE) (25)Mg(2+)as a function amount Mt-endogenous iron ions. strong but negative (r = -0.88) correlation between (25)Mg-MIE Mt[Fe(2+)]...
Introduction . Massive perioperative blood loss that accompanies major surgical interventions is a specific critical condition, the pathogenesis of which dominated by severe hypovolemia, anemia, and threatening coagulopathy in combination with powerful shockogenic sympathoadrenal stress. Both massive itself transfusion are associated significant risk serious complications, including death. It worth noting information on survival patients after replacement several circulating volume (CBV)...
Ligand efficiency is a widely used design parameter in drug discovery. The dependence of ligand on the concentration unit can be eliminated by defining terms sensitivity affinity to molecular size and this illustrated with reference fragment-to-lead optimizations.
It has been demonstrated that endogenous ssDNA40-60 and synthetic analogs exhibit a high affinity for the DNA repair enzyme polymerase β, they display significant antitumor activity in vitro vivo. The yield of from cancer cells under different conditions was investigated. percentage composition nitrogenous bases investigated compounds determined.
The inhibitory effect of D and L-polynucleotides a given length (40-50n) on the catalytic activity DNA polymerase β isolated from chromatin cells acute myeloid leukemia HL-60 was evaluated. synthesized L enantiomer found to have higher than enantiomers polynucleotides. work also proposes biophysical model that describes this effect.
BACKGROUND: Effective anesthesia is one of the most important factors in rapid and successful rehabilitation after surgery. Inadequately selected analgesia consequent pain significantly slow down recovery process are associated with several complications that cover almost all organs systems reduce patients quality life long term.
 OBJECTIVE: This study aimed to analyze 6 years clinical experience perioperative epidural Research Institute Pediatric Oncology, considering effectiveness,...
A significant population of ultrashort (50n-150n) single-stranded DNA fragments were found in exosome-free blood plasma retinoblastoma patients (6.84 ng ml-1), but not healthy donors. An original high resolution HPLC technique has been proposed to reveal and characterize this peculiarity. To solve task, a novel molecular size exclusion-anion exchange analytical was developed. Its applicability diagnostics oncogenesis research is quizzed here.