We have performed our study on a NEN-treated RB cell culture derived from real clinical autopsy material.3.5year-old male donor has died of massive complex abdominal trauma being previously RB-diagnosed with NMR and ultrasound tests, tumor located behind the eye globe equator line.This is first report ever magnetic isotope effects metal ions to cause clear anti-cancer consequences in retinoblastoma cells by depriving them DNA repair capabilities.Both molecular mechanism phenomenon its...

Human retinoblastoma cells were proven to possess some very unusual DNApolβ species. Being 23.5 kDa monomers, which itself is not common for the superfamily members, these chromatin associated proteins manifests most of DNApolβ-specifc functional peculiarities making them legitimate targets DNA repair cytostatic inhibitors. Particularly, tumor specific enzymes found be sensitive 25Mg2+-, 43Ca2+- and 67Zn2+-promoted magnetic isotope effects (MIE) caused a marked sequence growth limitation as...

Thio- and cyano- modified single-stranded poly(dNTP) sequences of different molecular sizes (20–200 n) the same lengths routine poly(NTP) species were tested for their impact on catalytic activities β-like DNA polymerases from chromatin HL-60, WERI-1A Y-79 cells as well affinity patterns in DNApolβ-poly(dNTP)/(NTP) pairs, respectively. An essential link between ultrashort (50–100 structures inhibitory effects towards cancer-specific β was found. A possible significance this phenomenon both...

Retinoblastoma is a malignant growth affecting retina. An original combination of modified Non-Markov and Gompertzian computational approaches proven being reliable tool for prediction tumor selective accumulation the bivalent metal isotopes (25Mg, 43Ca, 60Co, 67Zn, …) — releasing nanoparticles in human retinoblastoma cells. This mathematical model operates with starting point discriminative drug uptake caused by gap-like distinction between neighboring normal cell proliferation rates. takes...

A significant population of ultrashort (50-150n) single-stranded DNA fragments were found in exosome-free blood plasma retinoblastoma patients (6.84 ng mL-1), but not healthy donors. An original high resolution HPLC technique has been proposed to reveal and characterize this peculiarity. To solve task, a novel molecular size exclusion - anion exchange analytical was developed. Its applicability diagnostics oncogenesis research is quizzed here.

Abstract The 360° Multi-Side View Camera (360 MSVC) visual analytics service is a revolutionary tool that provides real-time video feed and detailed wellbore data analysis can be run simultaneously with most other coiled tubing (CT) downhole tools. Its unique capabilities were recently demonstrated during an operation in Saudi Arabia, where it successfully addressed challenge trilateral producer well stuck interval control valves (ICVs). well, drilled 2006, had ICVs have been immobile since...

A conventionally synthesized thio- and cyano-modified single-stranded poly(dNTP) sequences of different molecular sizes (20n - 200n) the same lengths routine poly(NTP) species were obtained through good services provided by Russian Federal Bioorganic Products Group ThermoFischer, Inc., then tested for their impact on catalytic activities β-like DNA polymerases from chromatin HL-60, WERI-1A Y-79 cells as well affinity patterns in DNApolβ-poly(dNTP)/ (NTP) pairs, respectively. An essential...

A significant population of ultrashort (50n-150n) single-stranded DNA fragments were found in exosome-free blood plasma retinoblastoma patients (6.84 ng ml-1), but not healthy donors. An original high resolution HPLC technique has been proposed to reveal and characterize this peculiarity. To solve task, a novel molecular size exclusion-anion exchange analytical was developed. Its applicability diagnostics oncogenesis research is quizzed here.

The electromechanical transmission of a mining dump truck is complex technical object with large number parameters for setting and monitoring, the quality cost characteristics service largely depend on convenience efficiency their implementation. To improve traction electrical equipment trucks maintenance, data system was organized that provides remote work control units. paper considers scheme transmission, description tool software monitoring configuring electric parameters. under...

As a result of experimental tests and operating experience BELAZ mining dump trucks, it has been established that the active safety system in difficult driving conditions on haul roads is great demand. Loss control slippery road as driver error can lead to serious accident costly equipment repairs. The article proposes algorithms use additional information from front wheel sensors. This made possible significantly improve truck controllability poor adhesion, preventing yaw wheels block,...

The paper proposes a new mathematical model of dynamic processes in typical spatially non-uniform biological system. problem modeling the dynamics neurovascular units brain under conditions ischemic stroke is formulated and solved. An investigation this conducted, numerical programmatic implementation corresponding proposed.

<p>Cytostatic activities of water and organic extracts prepared from medicinal higher plants including Ducrosia anethifolia should be analyzed by taking into account the “hidden” magnetic isotope effects stable metal isotopes (25Mg, 43Ca, 67Zn …) pre-(bio) fractionated in plant tissues. A multi-collector inductively coupled plasma mass spectrometry (MC – ICPMS) might successfully employed to reveal detail this specific peculiarity for further...