A5024146893- Immunotherapy and Immune Responses
- Drug Transport and Resistance Mechanisms
- Toxin Mechanisms and Immunotoxins
- Cancer Cells and Metastasis
- Monoclonal and Polyclonal Antibodies Research
- Computational Drug Discovery Methods
- Cancer Immunotherapy and Biomarkers
- Mesenchymal stem cell research
- Hemoglobin structure and function
- Melanoma and MAPK Pathways
- Immune Response and Inflammation
- Estrogen and related hormone effects
- Glycosylation and Glycoproteins Research
- Antimicrobial Peptides and Activities
- Lung Cancer Treatments and Mutations
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Cancer Research and Treatments
- Ferroptosis and cancer prognosis
- Microbial infections and disease research
- Mathematical Biology Tumor Growth
- Hematopoietic Stem Cell Transplantation
- Immune Cell Function and Interaction
- COVID-19 Clinical Research Studies
- Protein purification and stability
Ministry of Health of the Russian Federation
2017-2021
Russian Cancer Research Center NN Blokhin
2006-2017
Academy of Medical Sciences
1993-2011
Russian Academy of Sciences
1993-2011
Cancer Research Center
1993-2006
Non-degradable steel and titanium implants used to replace defects of the locomotor system or fabricate vascular stents provide maximum stability but have too many drawbacks.Currently, biodegradable magnesium alloys are considered as promising materials for creation fixation devices in orthopedics cardiovascular surgery.First attempts using magnesium-based bone were made early at beginning 20 th century, however, due a high corrosion rate gas formation they turned out be...
In the present study, we analyzed differential composition of blood serum from Ehrlich carcinoma-bearing and healthy male C57Bl/6 mice by isolating complexes hemoglobin other proteins a proteomic approach (gel filtration, gel electrophoresis, mass spectrometry). The fractions isolated mice- bearing tumors contained several with molecular weights 15, 65, 68, 100 kDa, while did not contain additional protein bands. These bands were identified MALDI-TOF as haptoglobin, albumin, homologue...
Literature review is devoted to immunosuppression in sepsis and possibilities of its correction.
Introduction. Results of the systemic chemotherapy in peritoneum canceromatosis are unsatisfactory because poor penetration anticancer drugs serous cavities due to presence ofperitoneal-plasma barrier. One possible ways enhance action cytostatic agents is use and hyperthermia, which, according some data, has an own cytotoxic effect. The purpose study. study effect ofdifferent modes hyperthermia on physiological activity transplantable lines tumor non-transformed cells. Results. Analysis...
Immune checkpoint inhibitors (ICT) therapy is a successful immunotherapy (IT) strategy that quite effective in number of patients with non-small cell lung cancer, melanoma, bladder breast cancer and others. Nevertheless, there need predictive markers for ICT personalized IT as far large group patients, the proportion which varies depending on tumor, who do not have clinical response to such therapy. The review summarizes theoretical aspects results trials dedicated various efficiency...
Введение.В рамках конструирования молекул с патогенетической направленностью к опухолевой клетке создан ряд химерных пептидов, включающих функциональный фрагмент аминокислотной последовательностью из группы SEQ ID NO: 1 -SEQ 17 и транспортную последовательность.Эти пептиды при целевой доставке в клетку способны обнаруживать короткие функциональные домены белках-регуляторах различных функций.Среди них ММ-D37K, блокирующий фазу G1 индуцирующий апоптоз клетках опухолей человека, том числе...
Введение. Разработка новых моделей диссеминированной меланомы кожи человека с наличием молекулярно-генетической мишени для таргетной терапии повышает результативность доклинических исследований in vitro и vivo антимеланомных средств их комбинаций. Такая возможность реализована путем адаптации к росту оригинальной линии клеток беспигментной mel Rac получению подкожного (п/к) ксенографта под контролем трансплантационных, морфологических, молекулярно-генетических (мутация NRAS)...
Introduction. Development of new models a human disseminated skin melanoma the with molecular-genetic targets for specific therapy increases productivity preclinical researches anti-melanoma drugs or their combinations in vitro and vivo. Such opportunity is realized by adaptation vivo original pigmented cell line mel Cher receiving subcutaneous (s. c.) xenograft under monitoring transplant, morphological, (V600E BRAF mutation) chemotherapeutic (sensitivity inhibitor kinases to vemurafenib)...
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Введение.Разработка новых ортотопических моделей опухолевого роста (surgical orthotopic implantation, SOI) открывает возможность доклинического изучения потенциального антиметастатического действия препаратов, в том числе направленных на лечение диссеминированного светлоклеточного рака почки, с использованием качестве имплантата фрагмента опухоли или метастаза от пациента.Использование подкожного (п/к) ксенографта оптимизации SOI расширением возможностей применения эксперименте.Наличие п/к...