A5057019905- Renal and related cancers
- Neuroblastoma Research and Treatments
- Pancreatic and Hepatic Oncology Research
- Cancer-related gene regulation
- Childhood Cancer Survivors' Quality of Life
- Urological Disorders and Treatments
- Chromatin Remodeling and Cancer
- Renal cell carcinoma treatment
- Wnt/β-catenin signaling in development and cancer
- Bioactive Natural Diterpenoids Research
- Cancer Mechanisms and Therapy
- Immune Cell Function and Interaction
- Kruppel-like factors research
- Cancer, Hypoxia, and Metabolism
- Lymphoma Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
Sun Yat-sen University
2008-2025
Sun Yat-sen University Cancer Center
2008-2025
State Key Laboratory of Oncology in South China
2021
Hainan Maternal and Child Health Hospital
2019
ABSTRACT Background Little progress has been made in determining prognostic factors for patients with high‐grade mature B‐cell non‐Hodgkin lymphoma (HG B‐NHL). Based on the important role of lymphocytes cancer progression, this study aimed to explore effect peripheral blood prognosis pediatric HG B‐NHL. Methods Patients aged less than 18 years newly diagnosed B‐NHL were enrolled. Peripheral lymphocyte subset levels detected at diagnosis, and their optimal cutoff values determined according...
Abstract Purpose : This study aimed to retrospectively analyze survival outcomes for Chinese patients with prechemotherapy blastemal predominant histology type Wilms tumors (WTs). Methods We collected and analyzed clinical data concerning aged <15 years favorable (FH) WTs treated at the Sun Yat‐Sen University Cancer Center from December 2005 May 2016, based on Children's Oncology Group protocol. Pathological specimens were through biopsy or surgical resection before initiation of...
Abstract Background Autosomal recessive Robinow syndrome (ARRS) is a rare genetic disorder, which affects the development of multiple systems, particularly bones. Objectives The aim this study was to investigate cause ARRS fetus and evaluate reliability whole‐exome sequencing (WES) in prenatal diagnosis on cases with indistinguishable malformation. Methods Clinical ultrasonic evaluations were conducted fetus, multiplatform techniques used identify variation responsible for RS. pathogenicity...
Malignant rhabdoid tumor of the kidney (RTK) is a rare and highly aggressive pediatric malignancy. Immune system dysfunction significantly correlated with initiation progression.We integrated analyzed expression profiles immune-related genes (IRGs) in 65 RTK patients based on Therapeutically Applicable Research to Generate Effective Treatments (TARGET) database. Prognostic related IRGs were using univariate multivariate analysis, which prognostic model was constructed. Correlation analysis...
The prognosis of relapsed or refractory pediatric Wilms tumor (WT) is dismal, and new salvage therapies are needed. This study aimed to evaluate the efficacy combination irinotecan a doxorubicin hydrochloride liposome regimen for WT.The present enrolled WT patients who were treated with AI (doxorubicin liposomes 40 mg/m2 per day, day 1, 50 90-min infusion, days 1-5; this was repeated every 3 weeks) at Sun Yat-sen University Cancer Center from July 2018 September 2020. response defined as...
The prognosis of recurrent or refractory advanced childhood solid tumor patients is very poor and new therapeutic strategies are in urgent need. This study aimed to determine the efficacy safety apatinib pediatric refractory/relapse patients.The retrospectively reviewed who were treated with apatinib, an oral small-molecule tyrosine kinase inhibitor (TKI) that targets vascular endothelial growth factor receptor-2 (VEGFR2), at Sun Yat-sen University Cancer Center (China) from January 2016...
Introduction: Renal cell carcinoma (RCC) is a very rare pediatric renal tumor. Robust evidence to guide treatment lacking and knowledge on targeted therapies immunotherapy mainly based adult studies. Currently, the International Society of Pediatric Oncology-Renal Tumor Study Group (SIOP-RTSG) 2016 UMBRELLA protocol recommends sunitinib for metastatic or unresectable RCC. This retrospective study describes effects tyrosine kinase inhibitors (TKI), anti-programmed death 1 (PD-(L)1) monoclonal...
Objective To investigate the anti-tumor effect of avastin for neuroblastoma (NB)xenografts mice and influence on serum vascular endothelial growth factor (sVEGF).Methods Human NB cells were incubated transplanted to nude get xenografts.NB treated with and/or cyclophosphamide (CPM).Avastin was administered via tail vein injection a dose 5 mg/kg once per week.CPM single 75 mg/kg.The killed 22nd day after treatment.The tumor volume inhibitory rate observed.The micro-vessel density detected by...
e22003 Background: Medical advances have been greatly improved in the survival rate for Wilms’ tumor, but is still dismal relapsed/refractory (R/R) patients. In present study, we aimed to investigated genomic profiling and incidence of germline cancer susceptibility mutations Chinese patients with R/R WT. Methods: From Jun 18, 2020 Dec 22, 2020, tumor specimens matched blood samples obtained from pediatric WT Sun Yat-Sen University Cancer Center were performed next-generation sequencing...
e22007 Background: To evaluate the efficacy of regimen combination irinotecan and doxorubicin hydrochloride liposome in relapsed/refractory pediatric Wilms’ tumor. Life quality toxicity are seriously considered assessed. Methods: The project stipulated 5-day course 50 mg/m 2 (90-minute infusion) 40mg/m every 3 weeks. Granulocyte colony-stimulating factor was applied when number neutrophil count lower than 1,000/ L. Results: 16 patients received 1to 8 courses (median, courses) this regimen,...
Purpose: The prognosis of the relapsed or refractory Wilms tumor (R/R WT) was dismal and new salvage chemotherapy needed. This study aimed to evaluate efficacy combination irinotecan doxorubicin hydrochloride liposome regimen (AI) for R/R WT. Methods: present enrolled WT who were treated with AI at Sun Yat-Sen University Cancer Center from July 2018 September 2020. response defined as best observed after last two cycle toxicity evaluated. Result: Total 16 patients median age 4.2 years (0.5...