A5040347711- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- Prostate Cancer Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Prostate Cancer Treatment and Research
- Advanced X-ray and CT Imaging
- MRI in cancer diagnosis
- Lung Cancer Diagnosis and Treatment
- Radiation Detection and Scintillator Technologies
- Endometrial and Cervical Cancer Treatments
- Muscle Physiology and Disorders
- Radiopharmaceutical Chemistry and Applications
- Soft Robotics and Applications
- Advances in Oncology and Radiotherapy
- Brain Metastases and Treatment
- Advanced MRI Techniques and Applications
- Ultrasound Imaging and Elastography
- Effects of Radiation Exposure
- Electron Spin Resonance Studies
- Photoacoustic and Ultrasonic Imaging
- Boron Compounds in Chemistry
- Hepatocellular Carcinoma Treatment and Prognosis
- Radiation Effects in Electronics
- AI in cancer detection
Johns Hopkins University
2018-2025
Johns Hopkins Medicine
2018-2025
The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
2022
Western University
2012-2020
Robarts Clinical Trials
2014-2017
Regional Cancer Center
2012
Various therapeutic approaches have been studied for the treatment of Duchenne muscular dystrophy (DMD), but none these led to significant long-term effects in patients. One reason this observed inefficacy may be use inappropriate animal models testing agents. The mdx mouse is most widely used murine model DMD, yet it does not fibrotic progression Other DMD are available that lack one or both alleles utrophin, a functional analog dystrophin. aim study was compare fibrosis and myofiber damage...
Abstract Purpose Open‐source GPU‐based Monte Carlo (MC) proton dose calculation algorithms provide high speed and unparalleled accuracy but can be complex to integrate with new applications remain slower than pencil beam (PB) methods, which sacrifice some physical for sub‐second plan calculation. We developed validated a Python package implementing double Gaussian PB algorithm intensity‐modulated therapy (IMPT) planning research requiring simple, widely compatible, ultra‐fast solution....
Purpose To develop and evaluate a volumetric modulated arc therapy (VMAT) machine parameter optimization (MPO) approach based on deep‐Q reinforcement learning (RL) capable of finding an optimal control policy using previous prostate cancer patient CT scans contours, applying the to new cases rapidly produce deliverable VMAT plans in simplified beam model. Methods A convolutional network was employed dose rate multileaf collimator C‐arm linear accelerator model current distribution state as...
Emerging data suggest that metastasis-directed therapy (MDT) improves outcomes in patients with oligometastatic castration-sensitive prostate cancer (omCSPC). Prostate-specific membrane antigen positron emission tomography (PSMA-PET) can detect occult metastatic disease, and PSMA response has been proposed as a biomarker for treatment response. Herein, we identify validate PSMA-PET metastasis-free survival (MFS) following MDT omCSPC.
Volumetric modulated arc therapy (VMAT) machine parameter optimization (MPO) remains computationally expensive and sensitive to input dose objectives creating challenges for manual automatic planning. Reinforcement learning (RL) involves through extensive trial-and-error, demonstrating performance exceeding humans, existing algorithms in several domains.
Purpose: To design, construct, and commission a set of computer-controlled motorized jaws for micro-CT/RT system to perform conformal image-guided small animal radiotherapy. Methods: The authors designed evaluated custom-built orthogonal jaws, which allows the delivery off-axis rectangular fields on GE eXplore CT 120 preclinical imaging system. in x direction are independently driven, while y-direction symmetric. All motors have backup encoders, verifying jaw positions. Mechanical...
Abstract Purpose To evaluate dosimetric changes detected using synthetic computed tomography (sCT) derived from online cone‐beam CTs (CBCT) in pediatric patients treated intensity‐modulated proton therapy (IMPT). Methods Ten undergoing IMPT and aligned daily gantry‐mounted CBCT were identified for retrospective analysis with anatomical sites fully encompassed the field of view. Dates when patient received both a quality assurance CT (qCT) routine evaluation. sCTs generated based on...
Sagittally reconstructed 3D (SR3D) ultrasound imaging shows promise for improved needle localization high-dose-rate prostate brachytherapy (HDR-BT); however, needles must be manually segmented intraoperatively while the patient is anesthetized to create a treatment plan. The purpose of this article was describe and validate an automatic segmentation algorithm designed HDR-BT, specifically capable simultaneously segmenting all in HDR-BT implant using single SR3D image with ~5 mm interneedle...
Stereotactic ablative radiation therapy (SABR) for oligometastatic prostate cancer (OMPC) may improve clinical outcomes, but current challenges in intrafraction tracking of multiple small targets limits treatment accuracy. A biology-guided (BgRT) delivery system incorporating positron emission tomography (PET) detectors is being developed to use radiotracer uptake as a biologic fiducial tumor geometric This study simulates prostate-specific membrane antigen (PSMA)-directed BgRT using cohort...
Purpose The MRI‐guided cervical cancer brachytherapy provides unparalleled soft‐tissue contrast for target and normal tissue contouring, but eliminates the ability to use conventional metallic fiducials radiation source path reconstruction as required treatment planning. Instead, is reconstructed by manually aligning a library model signal void produced applicator, which takes time intraoperatively precludes fully automated purpose of this study present validate an algorithm automatically...
Abstract Purpose The purpose of this work was to compare the dosimetry and delivery times 3D‐conformal (3DCRT)‐, volumetric modulated arc therapy (VMAT)‐, tomotherapy‐based approaches for spatially fractionated radiation deep tumor targets. Methods Two virtual GRID phantoms were created consisting 7 “target” cylinders (1‐cm diameter) aligned longitudinally along in a honey‐comb pattern, mimicking conventional block, with 2‐cm center‐to‐center spacing (GRID 2 cm ) 3‐cm 3 ), all contained...
Purpose This study aimed to quantitatively evaluate the range uncertainties that arise from daily cone-beam CT (CBCT) images for proton dose calculation compared using a measurement-based technique. Methods For head and thorax phantoms, wedge-shaped intensity-modulated therapy (IMPT) treatment plans were created such gradient of wedge intersected was measured with 2D ion chamber array. The distributions planes extracted IMPT plan calculated on CBCT. Treatment thymoma cancer patient treated...
Abstract Purpose To evaluate the relationship between delivered radiation (RT) and post-RT inversion-recovery ultrashort-echo-time (IR-UTE) MRI signal-intensity (SI) in gynecologic cancer patients treated with high-dose-rate (HDR) brachytherapy (BT). Methods Seven underwent whole-pelvis RT (WPRT) followed by BT to high-risk clinical target volume (HR-CTV). MR images were acquired at three time-points; pre-RT, post-WPRT/pre-BT, 3–6 months post-BT. Diffuse-fibrosis (F Diffuse ) was imaged a...
Vascular endothelial growth factor (VEGF) and other pro-angiogenic factors have been investigated to enhance muscle tissue perfusion repair in Duchenne muscular dystrophy (DMD). Current understanding is limited by a lack of functional data following vivo delivery these factors. We previously used dynamic contrast-enhanced computed tomography monitor disease progression murine models DMD, but no study date has utilized this imaging technique assess vascular therapy preclinical model DMD. In...
5011 Background: Emerging data suggest metastasis-directed therapy (MDT) improves outcomes in patients with oligometastatic castration-sensitive prostate cancer (omCSPC). Prostate-specific membrane antigen positron emission tomography (PSMA-PET/CT) can detect occult metastatic disease and has been proposed as a biomarker for treatment response. Herein we identify validate PSMA-PET clinical following MDT omCSPC. Methods: This was an international multi-institutional retrospective study of two...
To investigate the effects of subject motion and gantry rotation speed on computed tomography (CT) image quality over a range acquisition speeds for fan-beam (FB) cone-beam (CB) CT scanners, quantify geometric dosimetric errors introduced by FB CB sampling in context adaptive radiotherapy.Images phantoms were acquired using four scanners with 0.5 s/rotation (denoted FB-0.5), 1.9 (FB-1.9), 16.6 (CB-16.6), 60.0 (CB-60.0). A phantom presenting various tissue densities undergoing 4-s period...
<strong>Purpose:</strong> Multiparametric magnetic resonance imaging (MPMRI) supports detection and staging of prostate cancer, but the image characteristics needed for tumor boundary delineation to support focal therapy have not been widely investigated. We quantified detectability (image contrast between non-cancerous contralateral tissue) localizability neighboring Gleason score 7 (GS7) peripheral zone (PZ) tumors on MPMRI using contours mapped from histology accurate 2D–3D registration....
Heterogeneous target doses are a common by-product from attempts to improve normal tissue sparing in radiosurgery treatment planning. These regions of escalated dose within the may increase tumor control probability (TCP). Purposely embedding hot spots tumors during optimization also TCP. This study discusses and compares five approaches that not only eliminate homogeneity constraints, but maximize heterogeneity internal escalation.Co-planar volumetric modulated arc therapy (VMAT) plans were...