A5087490596- Medical Imaging Techniques and Applications
- Advanced X-ray and CT Imaging
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Health and Disease Prevention
- Orthopaedic implants and arthroplasty
- Total Knee Arthroplasty Outcomes
- Advanced MRI Techniques and Applications
- Coronary Interventions and Diagnostics
- Osteoarthritis Treatment and Mechanisms
- Advanced Radiotherapy Techniques
- Radiation Dose and Imaging
- Cardiac Imaging and Diagnostics
- Orthopedic Infections and Treatments
- Knee injuries and reconstruction techniques
- Intracranial Aneurysms: Treatment and Complications
- Ultrasound and Hyperthermia Applications
- Radiomics and Machine Learning in Medical Imaging
- Aortic aneurysm repair treatments
- Bone Tissue Engineering Materials
- Anatomy and Medical Technology
- Astro and Planetary Science
- Ultrasound Imaging and Elastography
- Medical Image Segmentation Techniques
- Atomic and Subatomic Physics Research
- Photoacoustic and Ultrasonic Imaging
Western University
2015-2024
Robarts Clinical Trials
2013-2024
University of Oxford
2022
London Health Sciences Centre
1998-2020
Fowler Kennedy Sport Medicine Clinic
2014-2020
Waitemata District Health Board
2017-2018
Transnational Press London
2017
Lawson Health Research Institute
1999-2012
Regional Cancer Center
2011-2012
Maastricht University
2012
To examine the early changes of articular cartilage and subchondral bone in DMM mouse model osteoarthritis, mice were subjected to or SHAM surgery sacrificed at 2-, 5- 10-week post-surgery. Catwalk gait analyses, Micro-Computed Tomography, Toluidine Blue, Picrosirius Red Tartrate-Resistant Acid Phosphatase (TRAP) staining used investigate patterns, joint morphology, bone, cartilage, collagen organization osteoclasts activity, respectively. Results showed OA progressed over time-course. Gait...
Knowledge of normal cerebrovascular volumetric flow rate (VFR) dynamics is interest for establishing baselines, and providing input data to model studies. Retrospectively gated phase contrast magnetic resonance imaging was used measure time-resolved VFR waveforms from the two internal carotid arteries (ICA) vertebral (VA) 17 young, volunteers (16M:1F) at rest in a supine posture. After normalizing each waveform its respective cycle-averaged VFR, timing amplitude feature points individual...
Knowledge of human blood-flow waveforms is required for in vitro investigations and numerical modelling. Parameters interest include: velocity flow waveform shapes, inter- intra-subject variability frequency content. We characterized the blood-velocity left right common carotid arteries (CCAs) 17 normal volunteers (24 to 34 years), analysing 3560 cardiac cycles total. Instantaneous peak-velocity (Vpeak) measurements were obtained using pulsed-Doppler ultrasound with simultaneous collection...
A consistent, quantitative, observer-independent method of characterising mammographic parenchymal pattern is described. The based on the calculation 'fractal dimension' digitised mammograms. degree correlation between classifications by a fractal-based system and those radiologists assessed. For set 70 mammograms, average weighted proportion agreement among three in calling Wolfe grades was 85%, while fractal classifier 84%. developed may prove to be useful establishing an index risk for...
Computational fluid dynamics (CFD) modeling of nominally patient-specific cerebral aneurysms is increasingly being used as a research tool to further understand the development, prognosis, and treatment brain aneurysms. We have previously developed virtual angiography indirectly validate CFD-predicted gross flow against routinely acquired digital subtraction angiograms. Toward more direct validation, here we compare detailed, velocity fields those measured using particle imaging velocimetry...
Small‐animal imaging has become increasingly more important as transgenic and knockout mice are produced to model human diseases. One technique that emerged is microcomputed tomography (micro‐CT). For live‐animal imaging, the precision in images will be determined by x‐ray dose given animal. As a result, we propose simple method predict noise performance of an micro‐CT system function image resolution. An ideal, quantum‐noise limited scanner, assumed have perfect resolution ideal efficiency,...
A novel remote catheter navigation system has been developed to reduce physical stress and irradiation the interventionalist during fluoroscopic X-ray guided intervention. The unique teleoperated design of this allows apply conventional axial radial motion, as used in current practice, an input placed a radiation-safe location control second inside procedure room. sensor (used measure motion catheter) manipulator manipulate are both presented. Performance evaluation was assessed by first...
Small-animal imaging has recently become an area of increased interest because more human diseases can be modeled in transgenic and knockout rodents. As a result, micro-computed tomography (micro-CT) systems are becoming common research laboratories, due to their ability achieve spatial resolution as high 10 µm, giving highly detailed anatomical information. Most recently, volumetric cone-beam micro-CT system using flat-panel detector (eXplore Ultra, GE Healthcare, London, ON) been developed...
X‐ray image intensifiers (XRIIs) have many applications in diagnostic imaging including acquisition of near‐real‐time projection images the intracranial and coronary vasculature. Recently, there has been some interest using this data to generate three‐dimensional (3‐D) computed tomographic (CT) reconstructions. The XRII x‐ray tube are rotated around object, acquiring sufficient for simultaneous reconstruction transverse slices. Three‐dimensional reconstructions compromised, however, if is...
Abstract Preclinical osteoarthritis (OA) models are often employed in studies investigating disease-modifying OA drugs (DMOADs). In this study we present a comprehensive, longitudinal evaluation of pathogenesis rat model OA, including histologic and biochemical analyses articular cartilage degradation assessment subchondral bone sclerosis. Male Sprague-Dawley rats underwent joint destabilization surgery by anterior cruciate ligament transection partial medial meniscectomy. The contralateral...
Three different methods for estimating the percentage of reduction in diameter internal carotid artery (ie, stenosis) have been proposed literature. Further comparisons were carried out with intent recommending a current standard determining stenosis from angiograms. Angiograms 112 patients obtained. For each angiogram, was estimated manner European Carotid Surgery Trial (ECST method), North American Symptomatic Endarterectomy (NASCET and by method using common lumen (CC method). Although...
Micro‐CT has become a powerful tool for small animal research, having the ability to obtain high‐resolution in vivo and ex images analyzing bone mineral content, organ vasculature, microarchitecture extraction. The use of exogenous contrast agents further extends micro‐CT techniques, but despite advancements agents, single‐energy is still limited cases where two different materials share similar grey‐scale intensity values. This study specifically addresses development multiple‐energy...
Bone sialoprotein (BSP) is an extracellular matrix protein found in mineralized tissues of the skeleton and dentition. BSP multifunctional, affecting cell attachment signaling through RGD integrin-binding region, acting as a positive regulator for mineral precipitation by nucleating hydroxyapatite crystals. present cementum, hard tissue covering tooth root that anchors periodontal ligament (PDL) attachment. To test our hypothesis plays important role cementogenesis, we analyzed development...
Abstract Diffuse idiopathic skeletal hyperostosis (DISH) is a noninflammatory spondyloarthropathy, characterized by ectopic calcification of spinal tissues. Symptoms include spine pain and stiffness, in severe cases dysphagia cord compression. The etiology DISH unknown there are no specific treatments. Recent studies have suggested role for purine metabolism the regulation biomineralization. Equilibrative nucleoside transporter 1 (ENT1) transfers hydrophilic nucleosides, such as adenosine,...
High-frequency, low-amplitude whole-body vibration (WBV) is being used to treat a range of musculoskeletal disorders; however, there surprisingly limited knowledge regarding its effect(s) on joint tissues. This study was undertaken examine the effects repeated exposure WBV bone and tissues in an vivo mouse model.Ten-week-old male mice were exposed vertical sinusoidal under conditions that mimic those clinically humans (30 minutes per day, 5 days week, at 45 Hz with peak acceleration 0.3g)....