A5091898203- Advanced Fiber Optic Sensors
- Photonic and Optical Devices
- Advanced MEMS and NEMS Technologies
- Geological and Geochemical Analysis
- RNA and protein synthesis mechanisms
- Geochemistry and Geologic Mapping
- RNA Research and Splicing
- Disaster Management and Resilience
- Structural Health Monitoring Techniques
- RNA modifications and cancer
- Semiconductor Lasers and Optical Devices
- earthquake and tectonic studies
- Geological and Geophysical Studies
- Advanced Sensor Technologies Research
- Limits and Structures in Graph Theory
- Optical Network Technologies
- Genetic Neurodegenerative Diseases
- High-pressure geophysics and materials
- Plant Micronutrient Interactions and Effects
- Radiation Therapy and Dosimetry
- Advanced Photonic Communication Systems
- Geophysics and Sensor Technology
- Sensor Technology and Measurement Systems
- Advanced Graph Theory Research
- Fluid Dynamics and Thin Films
Children's Hospital 1
2021-2025
Vietnam Academy of Science and Technology
2016-2025
Vietnam National University Ho Chi Minh City
2024
Hanoi University of Science and Technology
2012-2024
Vietnam National University of Agriculture
2018-2024
Ho Chi Minh City University of Technology and Education
2024
Johns Hopkins Medicine
2023-2024
Johns Hopkins University
2023-2024
Louisiana State University Health Sciences Center New Orleans
2024
Bình Dương University
2024
Despite rapid evolution in the area of microbial natural products chemistry, there is currently no open access database containing all microbially produced product structures. Lack availability these data preventing implementation new technologies science. Specifically, development computational strategies for compound characterization and identification are being hampered by lack a comprehensive known compounds against which to compare experimental data. The creation an access,...
Heavy metals are important environmental pollutants and their toxicity is a problem of increasing significance for ecological, evolutionary, nutritional, reasons. Of all non-essential heavy metals, cadmium (Cd) perhaps the metal that has attracted most attention in soil science plant nutrition due to its potential humans, also relative mobility soil-plant system. This review emphasises Cd on plants with regards physiological, biochemical aspects. It summarises toxic symptoms (i.e. growth...
Fragile X-associated tremor/ataxia syndrome (FXTAS) is an inherited neurodegenerative disorder caused by the expansion of 55-200 CGG repeats in 5 0 UTR FMR1.These expanded are transcribed and accumulate nuclear RNA aggregates that sequester one or more RNA-binding proteins, thus impairing their functions.Here, we have identified double-stranded RNAbinding protein DGCR8 binds to repeats, resulting partial sequestration its partner, DROSHA, within aggregates.Consequently, processing micro-RNAs...
Myotonic dystrophy type 1 (DM1) is a triplet repeating disorder caused by expanded CTG repeats in the 3′-untranslated region of dystrophia myotonica protein kinase (DMPK) gene. The transcribed fold into an RNA hairpin with multiple copies 5′CUG/3′GUC motif that binds splicing regulator muscleblind-like (MBNL1). Sequestration MBNL1 r(CUG) causes defects subset pre-mRNAs including insulin receptor, muscle-specific chloride ion channel, sarco(endo)plasmic reticulum Ca2+ ATPase 1, and cardiac...
Abstract In this study, we investigated the effect of Mn doping on crystal structure and distribution cations at tetrahedral octahedral sites in Co 1- x Fe 2 O 4 compounds (0 ≤ 0.4), synthesized utilizing a solid phase reaction method, X-ray diffraction (XRD) Raman spectroscopy measurements. The surface morphology chemical composition were studied using scanning electron microscope energy dispersive spectroscopy. Rietveld refinement XRD data Fullprof package demonstrate that all samples are...
Herein is described the identification of RNA internal loops that bind to derivatives neomycin B, neamine, tobramycin, and kanamycin A. loop-ligand partners were identified by a two-dimensional combinatorial screening (2DCS) platform probes chemical spaces simultaneously. In 2DCS, an aminoglycoside library immobilized onto agarose microarray was probed for binding 3 x nucleotide loop (81,920 interactions in duplicate single experiment). RNAs bound aminoglycosides harvested from array via gel...
The development of small molecule chemical probes or therapeutics that target RNA remains a significant challenge despite the great interest in such compounds. most barrier to compound is defining which and motif spaces interact specifically. Herein, we describe bioactive probe targets expanded r(CGG) repeats, r(CGG)exp, causes Fragile X-associated Tremor Ataxia Syndrome (FXTAS). was identified by using information on chemotypes motifs interact. Specifically,...
RNA drug targets are pervasive in cells, but methods to design small molecules that target them sparse. Herein, we report a general approach score the affinity and selectivity of motif–small molecule interactions identified via selection. Named High Throughput Structure–Activity Relationships Through Sequencing (HiT-StARTS), HiT-StARTS is statistical nature compares input nucleic acid sequences selected library members bind ligand high throughput sequencing. The allowed facile definition...
Potential RNA drug targets for small molecules are found throughout the human transcriptome, yet known to elicit a pharmacological response by directly targeting limited antibacterials. Herein, we describe AbsorbArray, molecule microarray-based approach that allows unmodified compounds, including FDA-approved drugs, be probed binding motif libraries in massively parallel format. Several classes bind kinase and topoisomerase inhibitors. The latter avidly bound Dicer site of oncogenic microRNA...
The 3D printing of a multifunctional hydrogel biomaterial with bioactivity for tissue engineering, good mechanical properties and biodegradability mediated by free encapsulated cellulase was proposed. Bioinks cellulase-laden cellulose nanofiber filled chitosan viscous suspensions were used to print enzymatic biodegradable biocompatible (CNF) reinforced (CHI) hydrogels. study the kinetics CNF degradation studied in situ fibroblast cell culture. To preserve enzyme stability as well guarantee...
Myotonic dystrophy type 2 (DM2) is an incurable neuromuscular disorder caused by a r(CCUG) expansion (r(CCUG)(exp)) that folds into extended hairpin with periodically repeating 2×2 nucleotide internal loops (5'CCUG/3'GUCC). We designed multivalent compounds improve DM2-associated defects using information about RNA-small molecule interactions. also report the first crystal structure of repeats refined to 2.35 Å. Structural analysis three 5'CCUG/3'GUCC repeat (L) reveals CU pairs in L1 are...
The design and principle of operation a novel fibre optic sensing system is presented. absolute extrinsic Fabry - Pérot interferometric (AEFPI) shown to possess high sensitivity, wide dynamic range real-time output signal. Applications the AEFPI high-performance civil structures are suggested. Multiplexing many such sensors achieved by employing path matching configuration.
We designed small molecules that bind the structure of RNA causes fragile X-associated tremor ataxia syndrome (FXTAS), an incurable neuromuscular disease. FXTAS is caused by expanded r(CGG) repeat (r(CGG)(exp)) inactivates a protein regulator alternative pre-mRNA splicing. Our compounds modulate r(CGG)(exp) toxicity in cellular models FXTAS, and pull-down experiments confirm they vivo. Importantly, compound binding does not affect translation downstream open reading frame (ORF). compared...
The isolation and structure elucidation of six new bacterial metabolites [spoxazomicin D (2), oxachelins B C (4, 5), carboxamides 6–8] 11 previously reported (1, 3, 9–12a, 14–18) from Streptomyces sp. RM-14-6 is reported. Structures were elucidated on the basis comprehensive 1D 2D NMR mass spectrometry data analysis, along with direct comparison to synthetic standards for 2, 11, 12a,b. Complete assignments known lenoremycin (9) sodium salt (10) also provided first time. Comparative analysis...
A special-purpose integrated circuit that accomplishes the real-time control and filtering tasks for JPL-Boeing micromachined gyroscopes using a flexible, low-power implementation is presented. Our exposition focuses on integration of prototype sensor, synthesis filters, subsequent performance closed-loop system. Identified sensor models are also presented because approach and, hence, architecture, motivated by special features dynamics.
Reliable multi-agent trajectory prediction is crucial for the safe planning and control of autonomous systems. Compared with single-agent cases, major challenge in simultaneously processing multiple agents lies modeling complex social interactions caused by various driving intentions road conditions. Previous methods typically leverage graph-based message propagation or attention mechanism to encapsulate such format marginal probabilistic distributions. However, it inherently sub-optimal. In...