A5014651854- Reading and Literacy Development
- Neural dynamics and brain function
- Cognitive and developmental aspects of mathematical skills
- Neuroscience and Music Perception
- Neurobiology of Language and Bilingualism
- EEG and Brain-Computer Interfaces
- Neuroscience and Neural Engineering
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Neural and Behavioral Psychology Studies
- Hearing Loss and Rehabilitation
- Language Development and Disorders
- Multisensory perception and integration
- Educational Practices and Challenges
- Visual perception and processing mechanisms
- Face Recognition and Perception
- Language, Metaphor, and Cognition
- Categorization, perception, and language
- Motor Control and Adaptation
- Phonetics and Phonology Research
- Neuroscience, Education and Cognitive Function
- Advanced Scientific Research Methods
- Color perception and design
- Tactile and Sensory Interactions
- Action Observation and Synchronization
McGovern Institute for Brain Research
2013-2024
Massachusetts Institute of Technology
2014-2024
University of Wisconsin–Madison
2022-2024
Harvard University
2016-2022
Institute of Cognitive and Brain Sciences
2016-2021
Vassar College
2021
Harvard University Press
2019
Boston Children's Hospital
2018
Texas Christian University
2016-2017
San Diego State University
2016
Developmental dyslexia, an unexplained difficulty in learning to read, has been associated with alterations white matter organization as measured by diffusion-weighted imaging. It is unknown, however, whether these differences structural connectivity are related the cause of dyslexia or if they consequences reading (e.g., less experience compensatory brain organization). Here, 40 kindergartners who had received little no instruction, we examined relation between behavioral predictors and...
Non-invasive Gamma ENtrainment Using Sensory stimulation (GENUS) at 40Hz reduces Alzheimer's disease (AD) pathology such as amyloid and tau levels, prevents cerebral atrophy, improves behavioral testing performance in mouse models of AD. Here, we report data from (1) a Phase 1 feasibility study (NCT04042922, ClinicalTrials.gov) cognitively normal volunteers (n = 25), patients with mild AD dementia 16), epilepsy who underwent intracranial electrode monitoring 2) to assess safety single brief...
Abstract Research suggests that early identification of developmental dyslexia is important for mitigating the negative effects dyslexia, including reduced educational attainment and increased socioemotional difficulties. The strongest pre‐literacy predictors are rapid automatized naming ( RAN ), phonological awareness PA letter knowledge, verbal short‐term memory. relationship among these constructs has been debated, several theories have emerged to explain unique role each in reading...
Reading is a learned skill crucial for educational attainment. Children from families of lower socioeconomic status (SES) tend to have poorer reading performance and this gap widens across years schooling. relies on the orchestration multiple neural systems integrated via specific white-matter pathways, but there limited understanding about whether these pathways relate differentially depending SES background. Kindergarten FA second-grade outcomes were investigated in an SES-diverse sample...
Abstract A functional region of left fusiform gyrus termed “the visual word form area” ( VWFA ) develops during reading acquisition to respond more strongly printed words than other stimuli. Here, we examined responses letters among 5‐ and 6‐year‐old early kindergarten children N = 48) with little or no school‐based instruction who varied in their ability. We used magnetic resonance imaging fMRI measure individual letters, false fonts, faces right gyri. then evaluated whether signal change...
Dyslexia is a common neurobiological disorder in which child fails to acquire typical word reading skills despite adequate opportunity and intelligence. The visual form area (VWFA) region within the left fusiform gyrus that specializes for print over course of acquisition often hypoactivated individuals with dyslexia. It currently unknown whether atypicalities this brain are already present kindergarten children who will subsequently develop Here, we measured fMRI activation response letters...
SUMMARY Non-invasive G amma EN trainment U sing S ensory stimuli (GENUS) at 40Hz reduced Alzheimer’s disease (AD) pathology, prevented cerebral atrophy and improved performance during behavioral testing in mouse models of AD. We report data from a safety study ( NCT04042922 ) randomized, placebo-controlled trial participants with probable mild AD dementia after 3 months one-hour daily light sound GENUS NCT04055376 to assess safety, compliance, entrainment possible effects on brain structure,...
Developmental dyslexia affects 40-60% of children with a familial risk (FHD+) compared to general prevalence 5-10%. Despite the increased risk, about half FHD+ develop typical reading abilities (FHD+Typical). Yet underlying neural characteristics favorable outcomes in at-risk remain unknown. Utilizing retrospective, longitudinal approach, this study examined whether putative protective mechanisms can be observed FHD+Typical at prereading stage. Functional and structural brain were 47...
What determines the cortical location where a given functionally specific region will arise in development? Here we test hypothesis that regions develop their characteristic locations because of pre-existing differences extrinsic connectivity to rest brain. We exploit Visual Word Form Area (VWFA) as case, it arises only after children learn read. scanned with diffusion and functional imaging at age five, before they learned read, 8, find VWFA develops this interval its particular child 8 can...
Abstract Background Our lab previously showed that 40 Hz sensory stimulation can modulate neural oscillations, ameliorate Alzheimer’s disease (AD) pathology, and improve cognition in AD mouse models (Iaccarino, Singer et al., Nature , 2016; Martorell, Paulson Cell 2019; Adaikkan Neuron 2019). To determine the safety feasibility of as a potential therapeutic for AD, human subjects, including patients, were exposed to various modalities their electrophysiological responses studied. Method We...
The mismatch negativity (MMN), an electrophysiological response to oddball auditory stimulus, is related reading ability in many studies. There are conflicting findings regarding exactly how the MMN relates risk or actual diagnosis of dyslexia/reading impairment, perhaps due heterogeneity abilities children with impairment. In this study, 166 English-speaking kindergarten oversampled for dyslexia completed behavioral assessments and a speech-syllable paradigm. We examined early late mean...
Abstract Robust and efficient speech perception relies on the interpretation of acoustically variable phoneme realizations, yet prior neuroimaging studies are inconclusive regarding degree to which subphonemic detail is maintained over time as categorical representations arise. It also unknown whether this depends demands listening task. We addressed these questions by using neural decoding quantify (dis)similarity brain response patterns evoked during two different tasks. recorded...
According to several influential theoretical frameworks, phonological deficits in dyslexia result from reduced sensitivity acoustic cues that are essential for the development of robust phonemic representations. Some accounts suggest these arise impairments rapid auditory adaptation processes either speech-specific or domain-general. Here, we examined specificity using a nonlinguistic tone anchoring (adaptation) task and linguistic
Abstract Hearing one’s own speech allows for acoustic self-monitoring in real time. Left-hemisphere motor planning regions are thought to give rise efferent predictions that can be compared true feedback sensory cortices, resulting neural suppression commensurate with the degree of overlap between predicted and actual sensations. Sensory prediction errors thus serve as a possible mechanism detection deviant sounds, which then feed back into corrective action, allowing online control...
When individuals make a movement that produces an unexpected outcome, they learn from the resulting error. This process, essential in both acquiring new motor skills and adapting to changing environments, critically relies on error sensitivity, which governs how much behavioral change results given Although computational evidence suggests sensitivity can response task demands, neural regarding flexibility of human brain is lacking. Here, we tested whether nervous system’s errors, as measured...
Abstract When individuals make a movement that produces an unexpected outcome, they learn from the resulting error. This process, essential in both acquiring new motor skills and adapting to changing environments, critically relies on error sensitivity, which governs how much behavioral change results given Although computational evidence suggests sensitivity can response task demands, neural regarding flexibility of human brain is lacking. Critically, nervous system auditory errors during...