A5083596996- Transcranial Magnetic Stimulation Studies
- EEG and Brain-Computer Interfaces
- Sleep and Wakefulness Research
- Photoacoustic and Ultrasonic Imaging
- Technology and Human Factors in Education and Health
- Functional Brain Connectivity Studies
- Muscle activation and electromyography studies
- Neural dynamics and brain function
- Ultrasound and Hyperthermia Applications
- Neuroscience and Neuropharmacology Research
- Sleep and related disorders
- Advanced MRI Techniques and Applications
- Neural and Behavioral Psychology Studies
- Blind Source Separation Techniques
- Photoreceptor and optogenetics research
- History of Medical Practice
- Craniofacial Disorders and Treatments
Johannes Gutenberg University Mainz
2021-2025
Leibniz Institute for Resilience Research
2020-2025
Stanford University
2024-2025
University Hospital and Clinics
2025
Neurosciences Institute
2024-2025
University Medical Center of the Johannes Gutenberg University Mainz
2021-2024
Stanford Medicine
2024
Krembil Research Institute
2023
University of Toronto
2023
Radboud University Nijmegen
2023
Transcranial ultrasonic stimulation (TUS) is rapidly emerging as a promising non-invasive neuromodulation technique. TUS already well-established in animal models, providing foundations to now optimize neuromodulatory efficacy for human applications. Across multiple studies, one protocol, pulsed at 1000 Hz, has consistently resulted motor cortical inhibition humans (Fomenko et al., 2020). At the same time, parallel research line highlighted potentially confounding influence of peripheral...
Thalamocortical sleep spindles, i.e., oscillatory bursts at ∼12-15 Hz of waxing and waning amplitude, are a hallmark feature non-rapid eye movement (NREM) believed to play key role in memory reactivation consolidation. Generated the thalamus projecting neocortex hippocampus, they phasically modulated by neocortical slow oscillations (<1 Hz) turn modulate hippocampal sharp-wave ripples (>80 Hz). This hierarchical cross-frequency nesting, where slower group faster ones into certain...
Transcranial magnetic stimulation (TMS) has emerged as a powerful clinical tool for treating neuropsychiatric conditions, yet our understanding of how TMS modulates neural circuits in the human brain remains limited. While decades research have established therapeutic efficacy TMS, fundamental questions persist about spatial and temporal dynamics effects, including which regions are activated modulated, long changes persist, mechanisms underlying antidepressant effect. Combining transcranial...
Transcranial magnetic stimulation (TMS) to the dorsolateral prefrontal cortex (DLPFC) is hypothesized relieve symptoms of depression by inhibiting activity in subgenual anterior cingulate (sgACC). However, we have a limited understanding how TMS influences neural sgACC, owing its deep location within brain. To better understand mechanism antidepressant response TMS, recruited two neurosurgical patients with indwelling electrodes and delivered pulses DLPFC while simultaneously recording local...
Transcranial ultrasonic stimulation (TUS) is rapidly emerging as a promising non-invasive neuromodulation technique. TUS already well-established in animal models, providing foundations to now optimize neuromodulatory efficacy for human applications. Across multiple studies, one protocol, pulsed at 1000 Hz, has consistently resulted motor cortical inhibition humans (Fomenko et al., 2020). At the same time, parallel research line highlighted potentially confounding influence of peripheral...
Transcranial ultrasonic stimulation (TUS) is rapidly emerging as a promising non-invasive neuromodulation technique. TUS already well-established in animal models, providing foundations to now optimize neuromodulatory efficacy for human applications. Across multiple studies, one protocol, pulsed at 1000 Hz, has consistently resulted motor cortical inhibition humans (Fomenko et al., 2020). At the same time, parallel research line highlighted potentially confounding influence of peripheral...
Summary Sleep spindles are a hallmark electroencephalographic feature of non‐rapid eye movement sleep, and believed to be instrumental for sleep‐dependent memory reactivation consolidation. However, direct proof their causal relevance is hard obtain, our understanding immediate neurophysiological consequences limited. To investigate role, need targeted in real‐time with sensory or non‐invasive brain‐stimulation techniques. While fully automated offline detection algorithms well established,...
Abstract Transcranial ultrasonic stimulation (TUS) is rapidly emerging as a promising non-invasive neuromodulation technique. TUS already well-established in animal models, providing foundations to now optimize neuromodulatory efficacy for human applications. Across multiple studies, one protocol, pulsed at 1000 Hz, has consistently resulted motor cortical inhibition humans (Fomenko et al., 2020). At the same time, parallel research line highlighted potentially confounding influence of...
Abstract Effectiveness of personalized, functional connectivity (FC)-guided TMS might further profit from optimizing coil position and orientation based on electric field (E-field) simulations. However, existing optimization routines (as implemented in, e.g., SimNIBS) typically only consider the E-field in a small cortical patch surrounding single target coordinate, thus ignoring whole-brain topography both subject-specific FC map E-field. To increase specificity FC-guided TMS, we developed...
Abstract Thalamocortical sleep spindles, i.e., oscillatory bursts at ∼12-15 Hz of waxing and waning amplitude, are a hallmark feature non-rapid eye movement (NREM) believed to play key role in sleep-dependent memory reactivation consolidation. Generated the thalamus projecting neocortex hippocampus, they phasically modulated by neocortical slow oscillations (<1 Hz) turn modulate hippocampal sharp-wave ripples (>80 Hz). This hierarchical cross-frequency nesting may enable...
Abstract Transcranial magnetic stimulation (TMS) applied to the motor cortex has revolutionized study of physiology in humans. Despite this, TMS-evoked electrophysiological responses show significant variability, due part inconsistencies between TMS pulse timing and ongoing brain oscillations. Variable limit mechanistic insights clinical efficacy, necessitating development methods precisely coordinate pulses phase relevant oscillatory activity. We introduce Sensory Entrained (seTMS), a novel...
Transcranial ultrasonic stimulation (TUS) is rapidly emerging as a promising non-invasive neuromodulation technique. TUS already well-established in animal models, providing foundations to now optimize neuromodulatory efficacy for human applications. Across multiple studies, one protocol, pulsed at 1000 Hz, has consistently resulted motor cortical inhibition humans. At the same time, parallel research line highlighted potentially confounding influence of peripheral auditory arising from...
Abstract Sleep spindles are a hallmark electroencephalographic (EEG) feature of non-rapid eye movement (NREM) sleep and believed to be instrumental for sleep-dependent memory reactivation consolidation. However, direct proof their causal relevance is hard obtain, our understanding immediate neurophysiological consequences limited. To investigate role, need targeted in real-time with sensory or non-invasive brain stimulation techniques. While fully automated offline detection algorithms well...