A5040750042- Cancer survivorship and care
- Frailty in Older Adults
- Palliative Care and End-of-Life Issues
- Childhood Cancer Survivors' Quality of Life
- Nutrition and Health in Aging
- Health Systems, Economic Evaluations, Quality of Life
- Cancer-related cognitive impairment studies
- Balance, Gait, and Falls Prevention
- Acute Myeloid Leukemia Research
- Chronic Disease Management Strategies
- Patient-Provider Communication in Healthcare
- Economic and Financial Impacts of Cancer
- Neutropenia and Cancer Infections
- Colorectal Cancer Treatments and Studies
- Pharmaceutical Practices and Patient Outcomes
- Physical Activity and Health
- Long-Term Effects of COVID-19
- Stroke Rehabilitation and Recovery
- Geriatric Care and Nursing Homes
- Patient Dignity and Privacy
- Parkinson's Disease and Spinal Disorders
- Health and Wellbeing Research
- Lymphatic System and Diseases
- Histone Deacetylase Inhibitors Research
- Health disparities and outcomes
University of Rochester Medical Center
2021-2025
University of Rochester
2022-2025
Amsterdam University Medical Centers
2023
Faculty of Public Health
2022
Older adults with cancer are vulnerable to declines in muscle performance (e.g., strength, speed, duration of muscular contraction), which associated worse cancer-related outcomes. Exercise-based interventions can mitigate these declines, but evidence their effect among older myeloid malignancies receiving outpatient treatment is limited. We explore change patients a single arm pilot study mobile health (mHealth) exercise intervention. Patients ≥ 60 years old chemotherapy completed...
Older adults with advanced cancer frequently experience declines in physical performance and daily functioning during systemic therapy, higher patient‐reported symptomatic toxicities correlating new impairments performance. Although clinician‐rated do not predict performance, are associated increased risk of functional decline, suggesting that integrating both types assessments could guide interventions to address these declines.
Many older patients with myeloid neoplasms experience treatment-related toxicities. We previously demonstrated that a home-based, progressive aerobic walking and resistance exercise program (EXCAP) improved physical psychological outcomes in cancer. However, have more difficulty adhering to than younger patients. Reasons may include low motivation, transportation, limited access professionals. To improve adherence, we integrated mobile app EXCAP (GO-EXCAP) assessed its feasibility usability...
Abstract Background Older adults with myeloid malignancies are susceptible to treatment-related toxicities. Accelerated DNAm age, or the difference between DNA methylation (DNAm) age and chronological may be used as a biomarker of biological predict individuals at risk. In addition, cancer treatment can also lead accelerated age. Exercise is promising intervention reduce prevent functional, psychological, cognitive impairments in older patients malignancies, yet there little evidence effects...
Older adults with advanced cancer experience functional disability that warrants rehabilitation services; however, evidence indicates inconsistencies in referral. The purpose was to (1) identify predictors of geriatric assessment (GA)-driven referrals services and (2) explore associations between referral change function, health-related quality life (HRQoL), overall survival among older cancer.
Older patients with advanced cancer often have comorbidities that can worsen their and treatment outcomes. We assessed how a geriatric assessment (GA)-guided intervention guide conversations about among patients, oncologists, caregivers.
Abstract Background In a single‐arm pilot study, we assessed the feasibility and usefulness of an innovative patient‐centered communication tool (UR‐GOAL tool) that addresses aging‐related vulnerabilities, patient values, prognostic awareness for use in treatment decision making between older adults with newly diagnosed acute myeloid leukemia (AML), their caregivers, oncologists. Methods Primary metric was retention rate; >50% considered feasible. We collected recruitment rate,...
Tumor necrosis factor (TNF)α is a major regulator of inflammation. However, the epigenetic regulation TNFα in context an exercise intervention among older adults with cancer understudied. In this exploratory analysis, we used data from single-arm mobile health (mHealth) myeloid malignancies to 1) assess changes promoter methylation, mRNA expression, serum and other related-cytokine levels after intervention; 2) correlations between blood markers levels. Twenty patients were included. From...
<h3>Importance</h3> The functional status and physical performance of older adults with cancer are underassessed undertreated despite the high prevalence impaired in this population their associations chemotherapy-induced toxic effects mortality. <h3>Objective</h3> To examine association between providing oncologists a geriatric assessment (GA) summary recommendations having oncologist-patient conversations about performance. <h3>Design, Setting, Participants</h3> Data for secondary analysis...
Falls are a modifiable source of morbidity for older adults with cancer, yet underassessed in oncology practice. In this secondary analysis nationwide cluster-randomized controlled trial, we examined characteristics associated patient-oncologist conversations about falls, and whether oncologist knowledge geriatric assessment (GA) resulted more conversations.Eligible patients (ClinicalTrials.gov identifier: NCT02107443) were age ≥ 70 years, had stage III/IV solid tumor or lymphoma, being...
Abstract Patients with acute myeloid leukemia (AML) often undergo physical decline leading to negative outcomes. Identification of distinct trajectories may help guide clinical decision-making and supportive care interventions. We built group-based trajectory models (GBTM) find change in the Functional Assessment Cancer Therapy Physical Well-Being (FACT-PWB) subscale (up 5 time points over 0 200 days follow-up) using data from adults newly diagnosed AML 4 studies. also estimated association...
11112 Background: Despite extensive research on unmet care needs in older adults (ages ≥65) with cancer, few studies explore the reasons for needs, knowledge of which can inform future interventions. We aimed to identity cancer and associated factors. Methods: Our analyses included community-dwelling from 2015–2019 National Health Aging Trends Study (NHATS). NHATS captures 12 activities three domains: daily living (ADL), instrumental ADL (IADL), mobility. separately evaluated two categories...