A5053863730- RNA modifications and cancer
- RNA Research and Splicing
- Frailty in Older Adults
- Palliative Care and End-of-Life Issues
- Cancer survivorship and care
- RNA and protein synthesis mechanisms
- Cancer, Hypoxia, and Metabolism
- Insect and Arachnid Ecology and Behavior
- RNA regulation and disease
- Animal Behavior and Reproduction
- Protein Tyrosine Phosphatases
- Health and Wellbeing Research
- 14-3-3 protein interactions
- Plant and animal studies
- Cancer-related molecular mechanisms research
- Medical Imaging and Pathology Studies
- Molecular Biology Techniques and Applications
- Health Systems, Economic Evaluations, Quality of Life
University of North Carolina at Chapel Hill
2023-2024
University of North Carolina Health Care
2024
University of Rochester
2023
University of Rochester Medical Center
2021-2022
A geriatric assessment (GA) intervention improves communication about aging-related concerns, but its effect on in patients with various levels of frailty is unknown.
<h3>Importance</h3> The functional status and physical performance of older adults with cancer are underassessed undertreated despite the high prevalence impaired in this population their associations chemotherapy-induced toxic effects mortality. <h3>Objective</h3> To examine association between providing oncologists a geriatric assessment (GA) summary recommendations having oncologist-patient conversations about performance. <h3>Design, Setting, Participants</h3> Data for secondary analysis...
Scaffold attachment factor B (SAFB) is a conserved RNA-binding protein that essential for early mammalian development. However, the functions of SAFB in mouse embryonic stem cells (ESCs) have not been characterized. Using RNA immunoprecipitation followed by RNA-seq (RIP-seq), we examined RNAs associated with wild-type and SAFB/SAFB2 double-knockout ESCs. predominantly introns protein-coding genes through purine-rich motifs. The transcript most enriched association was lncRNA
Abstract While oncogenic KRAS is believed to drive pancreatic cancer by maintaining active ERK signaling, our studies suggest that signaling can be also regulated in a KRAS-independent manner. We found survival motor neuron domain containing 1 (SMNDC1), poorly studied splicing factor amplified or upregulated 30% of ductal adenocarcinomas (PDACs) and associated with lower rates patients. To determine the role SMNDC1 PDACs, we conducted loss- gain-of-function this drives tumor growth promoting...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is among the most aggressive and lethal cancers, mainly due to its high resistance existing treatments. The standard treatment for PDAC involves chemotherapy, either with Gemcitabine (GEM) combined paclitaxel or FOLFIRINOX regimen (5-fluorouracil (5FU), leucovorin, irinotecan, oxaliplatin). However, PDACs rapidly develop these therapies. Similar observed new treatments targeting KRAS-MAPK pathway, which crucial in driving PDAC. Our preliminary...
While evolution is often considered from a DNA- and protein-centric view, RNA-based regulation can also impact gene expression protein sequences. Here we examined interspecies differences in RNA-protein interactions using the conserved neuronal RNA binding protein, Unkempt (UNK) as model. We find that roughly half of mRNAs bound human are mouse. Unexpectedly, even when transcript-level was across species differential motif usage prevalent. To understand biochemical basis UNK-RNA...
Abstract Clear cell renal carcinoma (ccRCC) is the 8th most common cancer in United States, constituting 75% of all kidney cases. RCC along with melanoma has traditionally been viewed as an immunotherapy responsive disease a storied history treatments including high dose interleukin 2 (IL2), interferon, and allogeneic stem transplant. Indeed, was one first tumor types to garner FDA approval for PD1 immune checkpoint inhibition (ICI). However, unlike melanoma, tumors do not have mutational...
ABSTRACT Species vary in their ability to adapt rapid changes, with the presence of genetic variation often facilitating long-term evolutionary responses. Given impending threat climate change, it is critical investigate how facilitates persistence and possible range expansion animals. Here, we combine genomic climatic data characterize drivers local adaptation widely distributed, social wasp Mischocyttarus mexicanus cubicola . Using whole genome sequence data, show that adaptive linked a...
12010 Background: Despite high prevalence of functional status (FS) and physical performance (PP) impairments among older adults with cancer, standardized assessments interventions are not routinely used in oncology care. This study characterized how oncologist knowledge Geriatric Assessment (GA) results influenced conversations GA-guided recommendations addressing FS PP concerns. Methods: Data were from a NCORP funded (UG1CA189961) nationwide cluster randomized controlled trial...