A5083962440- Nanoparticle-Based Drug Delivery
- Cardiovascular Disease and Adiposity
- Extracellular vesicles in disease
- Nanoplatforms for cancer theranostics
- Adipokines, Inflammation, and Metabolic Diseases
- Advanced Drug Delivery Systems
- Gastric Cancer Management and Outcomes
- Lipid Membrane Structure and Behavior
- Cancer, Hypoxia, and Metabolism
- Angiogenesis and VEGF in Cancer
- Coagulation and Flocculation Studies
- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- nanoparticles nucleation surface interactions
- Gold and Silver Nanoparticles Synthesis and Applications
- Cancer Cells and Metastasis
- Cancer, Lipids, and Metabolism
- Global Cancer Incidence and Screening
- Adipose Tissue and Metabolism
- Solid-state spectroscopy and crystallography
- Advancements in Transdermal Drug Delivery
- Circular RNAs in diseases
- HIV-related health complications and treatments
- Pancreatic and Hepatic Oncology Research
- Inflammatory Biomarkers in Disease Prognosis
Rajshahi University of Engineering and Technology
2024
University of Dhaka
2024
University of Oklahoma Health Sciences Center
2018-2024
Eastern Medical College and Hospital
2024
Bangladesh University of Textiles
2024
California Northstate University
2022
National Institute of Cancer Research and Hospital
2007-2021
University of Rhode Island
2017-2018
University of Oklahoma
2016
Hokkaido University
2010-2015
Altered tumor microenvironment (TME) arising from a bidirectional crosstalk between the pancreatic cancer cells (PCCs) and stellate (PSCs) is implicated in dismal prognosis ductal adenocarcinoma (PDAC), yet effective strategies to disrupt lacking. Here, we demonstrate that gold nanoparticles (AuNPs) inhibit proliferation migration of both PCCs PSCs by disrupting communication via alteration cell secretome. Analyzing key proteins identified functional network AuNP-altered secretome PSCs,...
Nanoparticle modification with poly(ethylene glycol) (PEG) is a widely used surface engineering strategy in nanomedicine. However, since the artificial PEG polymer may adversely impact nanomedicine safety and efficacy, alternative modifications are needed. Here, we explored "self" polysaccharide heparosan (HEP) to prepare colloidally stable HEP-coated nanoparticles, including gold silver nanoparticles liposomes. We found that HEP-coating reduced nanoparticle protein corona formation as...
Activated cancer-associated fibroblasts (CAFs) play a major role in the poor outcome many diseases including pancreatic cancer. Normally quiescent with high lipid content and low proliferative capacity, CAFs receiving cues from cancer cells tumor microenvironment become activated transformed into lipid-deprived highly myofibroblast type phenotype. Therefore, reversal of to quiescence state is an important area investigation that may help therapeutic management number Here, we describe unique...
Abstract Protein/subunit vaccines often require external adjuvants to induce protective immunity. Due the safety concern of chemical adjuvants, physical were recently explored boost vaccination. Physical use energies rather than chemicals stimulate tissue stress and endogenous danger signal release Here we present potency non-invasive radiofrequency treatment intradermal vaccination in murine models. We show can increase protein antigen-induced humoral cellular immune responses with adjuvant...
It is currently recognized that perpetual cross talk among key players in tumor microenvironment such as cancer cells (CCs), associated fibroblasts (CAFs), and endothelial (ECs) plays a critical role progression, metastasis, therapy resistance. Disruption of the may be useful to improve outcome therapeutics for which limited options are available. In current study we investigate use gold nanoparticles (AuNPs) therapeutic tool disrupt multicellular within TME with an emphasis on inhibiting...
The stringent expression of the hypoxia inducible factor-1α (HIF-1α) is critical to a variety pathophysiological conditions. We reveal that, in normoxia, enzymatic action cystathionine β-synthase (CBS) produces H
Cancer-associated fibroblasts (CAFs) are a major constituent of the tumor microenvironment (TME) and an important contributor to cancer progression therapeutic resistance. Regulation CAF activation is promising strategy influence outcomes. Here, we report that ovarian cells (OCs) TME promote CAFs, whereas gold nanoparticles (GNPs) 20 nm in diameter inhibit activation, as demonstrated by changes cell morphology, migration, molecular markers. GNPs exert effect altering levels multiple...
Gene silencing using small-interfering RNA (siRNA) is a viable therapeutic approach; however, the lack of effective delivery systems limits its clinical translation. Herein, we doped conventional siRNA-liposomal formulations with gold nanoparticles to create "auroliposomes," which significantly enhanced gene silencing. We targeted MICU1, novel glycolytic switch in ovarian cancer, and delivered MICU1-siRNA three systems-commercial transfection agents, liposomes, auroliposomes. Low-dose siRNA...
Background: Serum albumin, a marker of nutritional status, has been associated with surgical outcomes. This study evaluated the correlation between serum albumin levels and early postoperative complications in gastric cancer surgery patients. Methods: A prospective cross-sectional observational was conducted from July 2017 to March 2019 at National Institute Cancer Research Hospital (NICRH), Dhaka. Forty patients biopsy-proven operable carcinoma were included using purposive sampling....
Abstract Background Ovarian cancer is one of the deadliest gynecological malignancies. While overall survival ovarian patients has slightly improved in recent years developed world, it remains clinically challenging due to its frequent late diagnosis and lack reliable diagnostic and/or prognostic markers. The aim this study was identify potential new molecular target proteins (NMTPs) responsible for poor outcomes. When nanoparticles (NP) are exposed biological fluids, a protein coat, termed...
Because the functional apoptosis-initiating protein, cytochrome C (CytC) is rapidly cleared from circulation (t1/2 (half-life): 4 minutes), it cannot be used for in vivo therapy. We report herein on a hitherto unreported strategy delivering exogenous CytC as potential and safe antiobesity drug preventing diet-induced obesity, most common type of obesity humans. The activity encapsulated prohibitin (a white fat vessel-specific receptor)-targeted nanoparticles (PTNP) was evaluated...
Abstract By exploiting the self‐therapeutic properties of gold nanoparticles (GNPs) a molecular axis that promotes growth high‐grade serous ovarian cancer (HGSOC), one deadliest gynecologic malignancies with poorly understood underlying mechanisms, has been identified. The biodistribution and toxicity GNPs administered by intravenous or intraperitoneal injection, both as single dose repeated dosing over two weeks are first assessed; no biochemical histological to vital organs is found. Using...