A5012245210- Bone health and treatments
- Histone Deacetylase Inhibitors Research
- Peptidase Inhibition and Analysis
- Protease and Inhibitor Mechanisms
- Multiple Myeloma Research and Treatments
- Prostate Cancer Treatment and Research
- Protein Degradation and Inhibitors
- Cancer, Hypoxia, and Metabolism
- Angiogenesis and VEGF in Cancer
- Proteoglycans and glycosaminoglycans research
- Thermoregulation and physiological responses
- Epigenetics and DNA Methylation
- Thermal Regulation in Medicine
- Cancer Treatment and Pharmacology
- Anesthesia and Sedative Agents
- Cytokine Signaling Pathways and Interactions
- Cancer survivorship and care
- Cancer Diagnosis and Treatment
- Marine Sponges and Natural Products
- Glycosylation and Glycoproteins Research
- Health Education and Validation
- Dermatological and COVID-19 studies
- Subtitles and Audiovisual Media
- Dermatologic Treatments and Research
- Sarcoma Diagnosis and Treatment
University of Rochester Medical Center
2024
University of Rochester
2023-2024
Moffitt Cancer Center
2013-2024
University of South Florida
2016-2024
Cancer Research Center
2016-2020
Memorial Sloan Kettering Cancer Center
2012
University of California, San Francisco
1991-1993
Gladstone Institutes
1992
Glioblastoma (GBM) is distinguished by a high degree of intratumoral heterogeneity, which extends to the pattern expression and amplification receptor tyrosine kinases (RTKs). Although most GBMs harbor RTK amplifications, clinical trials small-molecule inhibitors targeting individual RTKs have been disappointing date. Activation multiple within provides theoretical mechanism resistance; however, spectrum functional dependence among tumor cell subpopulations in actual tumors unknown. We...
The authors tested the hypotheses that isoflurane anesthesia increases threshold for sweating but minimally decreases gain (sensitivity) or maximum intensity of this response and thermoregulatory responses to hyperthermia are similar in anesthetized men women. Sweating core was studied five women during 0, 0.8, 1.2% end-tidal anesthesia. Thigh quantified by measuring gas flow, relative humidity, temperature passing over a known surface area. distal esophageal triggering considered threshold,...
Abstract Bone metastatic prostate cancer (PCa) promotes mesenchymal stem cell (MSC) recruitment and their differentiation into osteoblasts. However, the effects of bone-marrow derived MSCs on PCa cells are less explored. Here, we report MSC-derived interleukin-28 (IL-28) triggers apoptosis via IL-28 receptor alpha (IL-28Rα)-STAT1 signaling. chronic exposure to drives selection that resistant IL-28-induced therapeutics such as docetaxel. Further, MSC-selected/IL-28-resistant grow at...
Systemic therapy has improved osteosarcoma event-free and overall survival, but 30-50% of patients originally diagnosed will have progressive or recurrent disease, which is difficult to cure. Osteosarcoma a complex karyotype, with loss p53 in the vast majority cases an absence recurrent, targetable pathways. In this study, we explored 54 agents that are clinically approved for other oncologic indications, active clinical development, others promising preclinical data at achievable...
Cancer remains a formidable global health challenge, with metastasis being key contributor to its lethality. Abundant high molecular mass hyaluronic acid, major non-protein component of extracellular matrix, protects naked mole rats from cancer and reduces incidence in mice. Hyaluronidase plays critical role degrading acid is frequently overexpressed metastatic cancer. Here we investigated the potential targeting hyaluronidases reduce metastasis. A throughput screen identified delphinidin,...
Abstract Overall survival rates for patients with advanced osteosarcoma have remained static over three decades. An in vitro analysis of cell lines sensitivity to an array approved cancer therapies revealed that panobinostat, a broad spectrum histone deacetalyase (HDAC) inhibitor, is highly effective at triggering death. Using vivo models orthotopic and metastatic osteosarcoma, here we report panobinostat impairs the growth primary bone spontaneous metastasis lung, most common site this...
We have previously demonstrated that the acetyl low density lipoprotein (LDL), or scavenger, receptor is expressed by rabbit smooth muscle cells (SMCs) and fibroblasts. Moreover, activity in fibroblasts was regulated over a wide range preincubating with secretion products from human platelets phorbol esters. The current studies were undertaken to examine regulation of expression SMCs, characterize further SMCs fibroblasts, determine whether incubating these chemically modified lipoproteins...
Abstract Multiple myeloma promotes systemic skeletal bone disease that greatly contributes to patient morbidity. Resorption of type I collagen–rich matrix by activated osteoclasts results in the release sequestered growth factors can drive progression disease. Matrix metalloproteinase-13 (MMP13) is a collagenase expressed predominantly skeleton mesenchymal stromal cells (MSC) and MSC-derived osteoblasts. Histochemical analysis human multiple specimens also demonstrated MMP13 largely...
Abstract Osteosarcoma (OS) frequently metastasizes to lung where it greatly contributes patient mortality. Frustratingly, OS treatment options have remained static due a paucity of strong pre-clinical evidence motivate clinical trials. To identify therapeutic targets, we assessed number FDA approved therapies for their cytotoxic effects. We found that histone deacetylase (HDAC) inhibitors (panobinostat and romidepsin) limited viability at low nM were highly effective the metastatic disease...
Abstract Cancer remains a formidable global health challenge, with metastasis being key contributor to its lethality. Abundant high molecular weight hyaluronic acid, major non-protein component of extracellular matrix, protects naked mole rats from cancer and reduces incidence in mice. Hyaluronidase plays critical role degrading acid is frequently overexpressed metastatic cancer. We investigated the potential targeting hyaluronidases reduce metastasis. High throughput screening identified...
Abstract Cancer remains a formidable global health challenge, with metastasis being key contributor to its lethality. Abundant high molecular mass hyaluronic acid, major non-protein component of extracellular matrix, protects naked mole rats from cancer and reduces incidence in mice. Hyaluronidase plays critical role degrading acid is frequently overexpressed metastatic cancer. Here we investigated the potential targeting hyaluronidases reduce metastasis. High throughput screen identified...
Abstract Background: Cancer-related fatigue (CRF) is one of the most pervasive side effects cancer and its treatment, reported by nearly 90% patients. Physical activity (PA) during treatment may prevent or lessen CRF burden. Current aerobic PA guidelines for patients recommend at least 150 minutes moderate 75 vigorous some equivalent combination (MVPA). Many have difficulty meeting these however, not be necessary to alleviate CRF. This study evaluated patterns below recommended their...
1527 Background: Understanding of information needs and information-seeking styles patients with cancer is critical for shared decision-making high quality care. Most want to be involved in the process but have unmet regarding their disease its treatment. The goal this study 1) identify 2) investigate factors associated pre-and-post treatment among cancer. Methods: This a secondary data analysis longitudinal 1003 from nine community oncology practices across United States that assessed We...
e24076 Background: Manypatients with cancer receiving hormone therapy experience difficulty sleeping and insomnia. Reiki is a technique where delivered to the patient either no or very light physical touch whereas traditional massage uses pressure movement by therapist manipulate soft tissue. Both have been shown others be effective in providing benefits sleep quality. This study first compare changes quality after treatments patients prostate breast therapy. Methods: Eighty-seven, (n = 56)...
12008 Background: Exercise is recommended by ASCO as a treatment for cancer-related fatigue (CRF) - one of the most pervasive toxicities patients with breast cancer experience. Current oncology guidelines recommend aerobic exercise (e.g., walking) at weekly dose 150 minutes moderate intensity or 75 vigorous intensity. While these recommendations exist and are effective treating CRF, struggle to achieve levels exercise, especially during chemotherapy. The purpose this study was determine...
Abstract Introduction: Bone metastasis is common in men with advanced prostate cancer. The resultant lesions are incurable and hallmarked by extensive osteoblast activity osteogenesis. To generate efficacious therapies a better understanding of the mechanisms governing cancer-bone interaction required. Mesenchymal stem cells (MSCs) can give rise to multiple cell types including osteoblasts. Given that bone reservoir for MSCs, we reasoned MSCs may contribute cancer induced formation....
Abstract The skeleton is a common target for prostate metastases. In bone, cancer cells induce extensive bone formation/osteogenesis by promoting osteoblast differentiation. This results in painful bony lesions that are incurable. precise mechanisms through which formation not well understood. Analysis of human and mouse specimens to metastasis demonstrate the presence MSCs (smooth muscle actin positive). Given precursors osteoblasts, we hypothesizes MSC recruitment microenvironment would...
Abstract Prostate cancer frequently metastasizes to bone, resulting in increased risk of fractures and severe pain that significantly impacts patient quality life. Bone metastatic prostate is currently incurable with standard care therapies being mainly palliative. In generates extensive osteogenic lesions by promoting osteoblast activity. Osteoblasts are specialized bone forming cells derived from mesenchymal stem cells. a bid find new molecular targets through which induces osteogenesis,...