A5054578212- Frailty in Older Adults
- Nutrition and Health in Aging
- Cancer survivorship and care
- Health Systems, Economic Evaluations, Quality of Life
- Occupational and environmental lung diseases
- Palliative Care and End-of-Life Issues
- Pharmaceutical Practices and Patient Outcomes
- Colorectal Cancer Treatments and Studies
- Cancer-related cognitive impairment studies
- Radiomics and Machine Learning in Medical Imaging
- Cancer Treatment and Pharmacology
- Pain Management and Opioid Use
- Dementia and Cognitive Impairment Research
- Viral Infections and Immunology Research
- Urinary Tract Infections Management
- Transgenic Plants and Applications
- Chemotherapy-induced cardiotoxicity and mitigation
- Glioma Diagnosis and Treatment
- Oral microbiology and periodontitis research
- Kawasaki Disease and Coronary Complications
- Renal Transplantation Outcomes and Treatments
- Childhood Cancer Survivors' Quality of Life
- Hepatocellular Carcinoma Treatment and Prognosis
- Bacterial Infections and Vaccines
- Advanced Radiotherapy Techniques
University of Alabama at Birmingham
1987-2024
The Ohio State University
2023
Luxembourg Institute of Health
2023
Rigshospitalet
2023
Royal Marsden Hospital
2023
Background Despite recent advances in cancer, racial disparities treatment outcomes persist, and their mechanisms are still not fully understood. The objective of this study was to examine differences frailty geriatric assessment impairments an unselected cohort older adults with newly diagnosed gastrointestinal (GI) malignancies. Methods This used data from the Cancer Aging Resilience Evaluation Registry, a prospective that enrolled (≥60 years) GI malignancies who were presenting for...
Abstract Background Older adults with cancer are at increased risk of treatment‐related toxicities and excess mortality. We evaluated whether a patient‐reported geriatric assessment (GA) based frailty index can identify those adverse outcomes. Methods (≥60 years) enrolled in single‐institutional prospective registry underwent GA initial evaluation our medical oncology clinic. Using deficit accumulation method, we constructed 44‐item (CARE‐FI), categorizing patients as robust, pre‐frail,...
Abstract Background Basic resource needs related to transportation, housing, food, and medications are important social determinants of health modifiable indicators poverty, but their role in modifying the risk frailty health‐related quality life (HRQoL) remains unknown. The goal our study was examine prevalence unmet basic association with HRQoL a cohort older adults cancer. Methods CARE registry prospectively enrolls (≥60 years) Assessments material hardship were added tool 8/2020. 44‐item...
Despite the known influences of both race- and aging-related factors in colorectal cancer outcomes mortality, limited literature is available on intersection between race impairments. To explore racial differences frailty geriatric deficit subdomains among patients with cancer. Retrospective study using data from Cancer Aging Resilience Evaluation registry. A comprehensive center Deep South. Older adults (aged ≥60 years) Measure assessment physical function, functional status, cognitive...
Abstract Background The European Working Group on Sarcopenia in Older People (EWGSOP) recommends SARC‐F as a tool for identifying sarcopenia among older adults. However, the role of adults with cancer remains unexplored. We aimed to evaluate diagnostic utility identify those sarcopenia, or low muscle mass (using skeletal index [SMI]), and myosteatosis density [SMD]) from computed tomography (CT) imaging association all‐cause mortality. Methods (≥60 years) presenting initial consultation at...
Identifying older patients with GI malignancies who are at increased risk of mortality remains challenging. The goal our study was to examine geriatric assessment (GA) predictors 1-year and explore the use a survival tree analysis in prospective cohort adults (≥ 60 years) newly diagnosed malignancies.
Frailty predicts poor outcomes in older adults with cancer, but how it differs between different cancer types is unknown. We examined differences pretreatment frailty colorectal (CRC), pancreatic, and hepatobiliary cancers.We included age 60 years or the above enrolled Cancer Aging Resilience Evaluation registry. was defined using a 44-item index constructed on basis of principles deficit accumulation (including several geriatric assessment impairments encompassing malnutrition, functional...
Gnotobiotic rats gastrically intubated with a total of 12.5 micrograms Streptococcus sobrinus ribosomal protein incorporated into cholesterol-based liposomes had significantly (P less than or equal to 0.01) fewer carious lesions on their molar surfaces did nonimmunized infected controls after challenge virulent organism. The immunized animals lower numbers molar-adherent S. cells and higher levels salivary immunoglobulin A antibodies whole ribosomes the control group. Dose-response studies...
Abstract Background Emotional support (ES) is the most frequently reported need among older adults with cancer. Yet, association of ES cancer outcomes largely unknown. This study examined health‐related quality life (HRQoL), mental health, and survival gastrointestinal (GI) malignancies. Methods We included newly diagnosed (≥60 years) GI undergoing self‐reported geriatric assessment at their first clinic visit. was measured using an adaptation Medical Outcomes Study (dichotomized adequate...
12046 Background: Older adults with cancer are at increased risk of treatment-related toxicity and mortality. A comprehensive geriatric assessment (GA) may uncover aging associated vulnerability identify those greatest adverse outcomes. We studied the association between a novel frailty index morbidity mortality among older GI malignancies. Methods: (≥60y) referred for initial consultation UAB oncology clinic 9/2017 to 12/2020 were enrolled in prospective Cancer Aging Resilience Evaluation...
Older adults comprise the majority of patients with gastrointestinal (GI) cancer. Geriatric assessments (GAs) are recommended for older cancer in part to detect aging-related impairments (e.g., frailty) associated early mortality. Social factors like social vulnerability may also influence impairments. However, association between and aging outcomes among is understudied.
Intrinsic capacity (IC) was introduced by the World Health Organization (WHO) as a marker of healthy aging, and is defined combination an individual's physical, mental, psychological capacities. This study aimed to assess IC via patient-reported geriatric assessment (GA) evaluate its association with survival among older adults gastrointestinal (GI) malignancies.
ABSTRACT Background Older adults with cancer are at an increased risk of treatment related toxicities and early death. Routinely collected clinico‐demographic characteristics inadequately explain this limiting accurate prognostication. Prior studies have suggested that altered body composition frailty independently associated worse survival among older cancer; however, their combined influence remains unclear. Methods We used data from a single‐institution prospective cohort study (≥ 60...
3095 Background: Considerable inter-individual variability in oxaliplatin toxicity exists older adults with GI cancers. Low lean body mass (LBM), commonly known as sarcopenia, influences and is not incorporated standard surface area-based dosing, which may affect PK tolerability, but has been examined systematically. Methods: We 26 (103 concentrations) cancers (NCT03998202). Using the transverse section at L3, skeletal muscle area (SMA) total adipose tissue (TAT) were quantified...
Abstract Background Food access is associated with higher gastrointestinal (GI) cancer mortality; however, its association frailty, which a predictor of premature mortality among older adults cancer, less understood. Methods The authors included 880 aged 60 years and who were recently diagnosed GI cancers undergoing self‐reported geriatric assessment at their first prechemotherapy visit to the University Alabama Birmingham oncology clinic. was measured using 2019 US Department Agriculture...