A5054048671- Cancer Risks and Factors
- Nutrition and Health in Aging
- Cancer survivorship and care
- Nutritional Studies and Diet
- Frailty in Older Adults
- Sleep and related disorders
- Radiation Therapy and Dosimetry
- Effects of Radiation Exposure
- Obesity, Physical Activity, Diet
- Body Composition Measurement Techniques
- Global Cancer Incidence and Screening
- Diet and metabolism studies
- Cancer, Lipids, and Metabolism
- Metabolism, Diabetes, and Cancer
- Radiomics and Machine Learning in Medical Imaging
- Sleep and Wakefulness Research
- Colorectal Cancer Treatments and Studies
- Nutrition, Genetics, and Disease
- Circadian rhythm and melatonin
- Radiation Dose and Imaging
- Colorectal Cancer Surgical Treatments
- Inflammatory Biomarkers in Disease Prognosis
- Dietary Effects on Health
- Cardiovascular Disease and Adiposity
- Social and Behavioral Studies
Kaiser Permanente
2016-2025
Colorado Permanente Medical Group
2022-2024
Felician College
2023
Rutgers Cancer Institute of New Jersey
2022
Rutgers, The State University of New Jersey
2022
City Of Hope National Medical Center
2019
Albert Einstein College of Medicine
2019
City of Hope
2019
UCLA Medical Center
2019
Wake Forest University
2018-2019
Sarcopenia (low muscle mass), poor quality radiodensity), and excess adiposity derived from computed tomography (CT) has been related to higher mortality in patients with metastatic breast cancer, but the association prognosis nonmetastatic cancer is unknown.To evaluate associations of all 3 body composition measures, clinically acquired CT at diagnosis, overall cancer.This observational study included 3241 women Kaiser Permanente Northern California Dana Farber Cancer Institute diagnosed...
Systemic inflammation and sarcopenia are easily evaluated, predict mortality in many cancers, potentially modifiable. The combination of may be able to identify patients with early-stage colorectal cancer (CRC) poor prognosis.To examine associations prediagnostic systemic at-diagnosis sarcopenia, determine whether these factors interact CRC survival, adjusting for age, ethnicity, sex, body mass index, stage, site.A prospective cohort 2470 Kaiser Permanente stage I III diagnosed from 2006...
Background: Body composition may partially explain the U-shaped association between body mass index (BMI) and colorectal cancer survival.Methods: Muscle adiposity at diagnosis survival were examined in a retrospective cohort using Kaplan-Meier curves, multivariable Cox regression, restricted cubic splines 3,262 early-stage (I-III) male (50%) female patients. Sarcopenia was defined optimal stratification sex- BMI-specific cut points. High as highest tertile of sex-specific total adipose...
Most studies of sleep and health outcomes rely on self-reported duration, although correlation with objective measures is poor. In this study, we defined sociodemographic characteristics associated misreporting assessed whether accounting for these factors better explains variation in duration among 2,086 participants the Hispanic Community Health Study/Study Latinos who completed more than 5 nights wrist actigraphy reported habitual bed/wake times from 2010 to 2013. Using linear regression,...
Television and insufficient sleep are associated with poor mental physical health. This study assessed associations of TV viewing bedroom duration from infancy to midchildhood.We studied 1864 children in Project Viva. Parents reported children's average daily (at 6 months annually 1-7 years) the presence a (annually 4-7 years). We used mixed effects models assess exposures contemporaneous sleep, adjusting for child age, gender, race/ethnicity, maternal education, income.Six hundred...
Obesity is associated with an increased risk of breast cancer, including the estrogen receptor (ER)-positive subtype in postmenopausal women. Whether excess adiposity women a normal body mass index (BMI; calculated as weight kilograms divided by height meters squared) unknown.
Inadequate sleep duration and quality increase the risk of obesity. Sleep timing, while less studied, is important in adolescents because increasing evening preferences (chronotypes), early school start times, irregular schedules may cause circadian misalignment.To investigate associations chronotype social jet lag with adiposity cardiometabolic young adolescents.Starting 1999, Project Viva recruited pregnant women from eastern Massachusetts. Mother-child in-person visits occurred throughout...
<h3>Importance</h3> Given the risks of postoperative morbidity and its consequent economic burden impairment to patients undergoing colon resection, evaluating risk factors associated with complications will allow stratification targeting supportive interventions. Evaluation muscle characteristics is an emerging area for improving preoperative stratification. <h3>Objective</h3> To examine associations complications, length hospital stay (LOS), readmission, mortality in cancer. <h3>Design,...
<h3>Importance</h3> Disadvantaged neighborhood-level and individual-level socioeconomic status (SES) have each been associated with suboptimal cancer care inferior outcomes. However, independent or synergistic associations between neighborhood individual disadvantage not fully examined, prior studies using simplistic SES measures may comprehensively assess multiple aspects of SES. <h3>Objective</h3> To investigate the (using a validated comprehensive composite measure) survival among...
Abstract There is growing interest from the oncology community to understand how body composition measures can be used improve delivery of clinical care for 18.1 million individuals diagnosed with cancer annually. Methods that distinguish muscle subcutaneous and visceral adipose tissue, such as computed tomography (CT), may offer new insights important risk factors improved prognostication outcomes over alternative mass index. In a meta‐analysis 38 studies, low area assessed clinically...
Low skeletal muscle radiodensity (SMD) is related to higher mortality in several cancers, but the association with colorectal cancer (CRC) prognosis unclear.This observational study included 3262 men and women from Kaiser Permanente Northern California population diagnosed between 2006 2011 AJCC stages I III CRC. The authors evaluated hazard ratios (HRs) of low SMD for all-cause CRC-specific mortality, assessed by computed tomography using optimal stratification, compared patients normal...
Abstract Background Body composition from computed tomography (CT) scans is associated with cancer outcomes including surgical complications, chemotoxicity, and survival. Most studies manually segment CT scans, but A utomatic B ody nalyser using C omputed image S egmentation (ABACS) software automatically segments muscle adipose tissues to speed analysis. Here, we externally evaluate ABACS in an independent dataset. Methods Among patients non‐metastatic colorectal ( n = 3102) breast 2888)...
Abstract Background Muscle abnormalities such as low muscle mass and radiodensity are well known risk factors for unfavourable cancer prognosis. However, little is in regard to the degree impact of longitudinal changes within context cancer. Here, we explore relationship between wasting mortality a large population‐based study patients with non‐metastatic colorectal (CRC). Methods A total 1924 stage I–III CRC who underwent surgical resection Kaiser Permanente Northern California Health...
Rest-activity patterns provide an indication of circadian rhythmicity in the free-living setting. We aimed to describe distributions rest-activity a sample adults and children across demographic variables. A (N = 590) 58) wore actigraph on their nondominant wrist for 7 days nights. generated from cosinor analysis (MESOR, acrophase magnitude) nonparametric rhythm (IS: interdaily stability; IV: intradaily variability; L5: least active 5-hour period; M10: most 10-hour RA: relative amplitude)....
For many chemotherapy regimens dosed based on body surface area (BSA), patients experience dose reductions or delays discontinue treatment, thereby reducing survival. Consideration of composition may be useful in individualizing dosing, but to the authors' knowledge few studies date have examined association with tolerance colon cancer.The authors identified nonmetastatic cancer who were diagnosed from 2006 through 2011 at Kaiser Permanente and received leucovorin calcium/calcium folinate,...
BACKGROUND AND OBJECTIVES: Shorter sleep duration is associated with childhood obesity. Few studies measure quantity and quality objectively or examine cardiometabolic biomarkers other than METHODS: This cross-sectional study of 829 adolescents derived duration, efficiency moderate-to-vigorous physical activity from &gt;5 days wrist actigraphy recording for &gt;10 hours/day. The main outcome was a metabolic risk score (mean 5 sex-specific z-scores waist circumference, systolic blood...
The relationship between various diet quality indices and risk of type 2 diabetes (T2D) remains unsettled. We compared associations 4 indices--the Alternate Mediterranean Diet Index, Healthy Eating Index 2010, the Dietary Approaches to Stop Hypertension (DASH) Index--with reported T2D in Women's Health Initiative, overall, by race/ethnicity, with/without adjustment for overweight/obesity at enrollment (a potential mediator). This cohort (n = 101,504) included postmenopausal women without who...
Although higher body mass index (BMI) increases the incidence of many cancers, BMI can also exhibit a null or U-shaped relationship with survival among patients existing disease; this association improved is termed obesity paradox. This review discusses possible explanations for paradox, prevalence and consequences low muscle in cancer patients, future research directions. It unlikely that methodological biases, such as reverse causality confounding, fully explain Rather, up to point, may...
Although most chemotherapies are dosed on body surface area or weight, composition (ie, the amount and distribution of muscle adipose tissues) is thought to be associated with chemotherapy tolerance adherence.To evaluate whether relative dose intensity (RDI) anthracycline taxane-based hematologic toxic effects lower RDI mediates association adiposity mortality.An observational cohort study prospectively collected electronic medical record data was conducted at Kaiser Permanente Northern...
Patients with cancer experience acute declines in physical function, hypothesized to reflect accelerated aging driven by cancer-related symptoms and effects of therapies. No study has examined long-term trajectories function site, stage, or treatment compared cancer-free controls.