A5046328305- Epilepsy research and treatment
- EEG and Brain-Computer Interfaces
- Neonatal and fetal brain pathology
- Neuroscience and Neuropharmacology Research
- Neurological disorders and treatments
- Pharmacological Effects and Toxicity Studies
- Functional Brain Connectivity Studies
- RNA regulation and disease
- Neural dynamics and brain function
- Vagus Nerve Stimulation Research
- Neuroscience and Neural Engineering
- Traumatic Brain Injury and Neurovascular Disturbances
- Metabolism and Genetic Disorders
- Botulinum Toxin and Related Neurological Disorders
- Bacterial Infections and Vaccines
- Advanced Neuroimaging Techniques and Applications
- Single-cell and spatial transcriptomics
- Alcoholism and Thiamine Deficiency
- Long-Term Effects of COVID-19
- Infectious Encephalopathies and Encephalitis
- Cerebrospinal fluid and hydrocephalus
- Cardiac Arrest and Resuscitation
- Leprosy Research and Treatment
- Mitochondrial Function and Pathology
- Healthcare Operations and Scheduling Optimization
Icahn School of Medicine at Mount Sinai
2015-2025
Mount Sinai Hospital
2020-2025
Massachusetts General Hospital
2022-2023
Harvard University
2022-2023
Mount Sinai Hospital
2013-2022
William S. Middleton Memorial Veterans Hospital
2022
Yale University
2012-2021
Neurology, Inc
2017-2020
Mount Sinai Hospital
2013-2019
Mount Sinai Health System
2017
INTRODUCTION In the early 2000s, a subcommittee of American Clinical Neurophysiology Society (ACNS) set out to “standardize terminology periodic and rhythmic EEG patterns in critically ill aid future research involving such patterns.” The initial proposed was published 2005.1 This presented at many meetings on several continents, subjected multiple rounds testing interrater reliability, underwent revisions, then as an ACNS guideline 2013.2 Interrater agreement 2012 version (published 2013)...
Seizures (SZs) and other SZ-like patterns of brain activity can harm the contribute to in-hospital death, particularly when prolonged. However, experts qualified interpret EEG data are scarce. Prior attempts automate this task have been limited by small or inadequately labeled samples not convincingly demonstrated generalizable expert-level performance. There exists a critical unmet need for an automated method classify SZs events with reliability. This study was conducted develop validate...
Opioid drugs produce their pharmacological effects by activating inhibitory guanine nucleotide-binding regulatory protein-linked μ, δ, and κ opioid receptors. One major effector for these receptors is adenylyl cyclase, which inhibited upon receptor activation. However, little known about of the ten forms cyclase are involved in mediating actions. Here we show that all behavioral morphine, including locomotor activation, analgesia, tolerance, reward, physical dependence withdrawal symptoms,...
Objective To compare by 7 Tesla (7T) magnetic resonance imaging (MRI) in patients with focal epilepsy who have non-lesional clinical MRI scans healthy controls. Methods 37 epilepsy, based on and electroencephalogram (EEG) data, MRIs at field strengths 21 controls were recruited for the 7T study. The protocol consisted of high resolution T1-weighted, T2-weighted susceptibility weighted sequences entire cortex. images read two neuroradiologists, initially blind to then reviewed a second time...
One-third of patients with epilepsy continue to have seizures despite antiepileptic medications. Some these refractory may not be candidates for surgical resection primarily because the seizure onset zones (SOZs) involve both hemispheres or are located in eloquent areas. The NeuroPace Responsive Neurostimulation System (RNS) is a closed-loop device that uses programmable detection and stimulation tailor therapy patient's individual neurophysiology. Here, we present our single-center...
Introduction For drug resistant epilepsy patients who are either not candidates for resective surgery or have already failed surgery, neuromodulation is a promising option. Neuromodulatory approaches include responsive neurostimulation (RNS), deep brain stimulation (DBS), and vagal nerve (VNS). Thalamocortical circuits involved in both generalized focal onset seizures. This paper explores the use of RNS centromedian nucleus thalamus (CMN) anterior thalamic (ANT) with epilepsy. Methods...
Abstract Febrile infection‐related epilepsy syndrome (FIRES) is a subset of new onset refractory status epilepticus (NORSE) that involves febrile infection prior to the epilepticus. It unclear whether FIRES and non‐FIRES NORSE are distinct conditions. Here, we compare 34 patients with 30 for demographics, clinical features, neuroimaging, outcomes. Because were younger than (median = 28 vs. 48 years old, p .048) more likely cryptogenic (odds ratio 6.89), next ran regression analysis using age...
Brief potentially ictal rhythmic discharges, termed B(I)RDs, have been described mainly in neonates, and their significance adults remains unclear.To describe the incidence of B(I)RDs critically ill patients investigate association with seizures outcome.We reviewed records prospectively identified serving as controls matched for age (±5 years) primary diagnosis.The prevalence during continuous electroencephalography functional outcome, measured by Glasgow Outcome Scale, were determined.We 20...
Abstract In response to the evolving treatment landscape for new‐onset refractory status epilepticus (NORSE) and publication of consensus recommendations in 2022, we conducted a comparative analysis NORSE management over time. Seventy‐seven patients were enrolled by 32 centers, from July 2016 August 2023, NORSE/FIRES biorepository at Yale. Immunotherapy was administered 88% after median 3 days, with 52% receiving second‐line immunotherapy 12 days (anakinra 29%, rituximab 25%, tocilizumab...
Summary Objective Secondary generalization of seizures has devastating consequences for patient safety and quality life. The aim this intracranial electroencephalography (ic EEG ) study was to investigate the differences in onset propagation patterns temporal lobe that remained focal versus those with secondary generalization, order better understand mechanism generalization. Methods A total 39 were analyzed nine patients who met following criteria: (1) ic ‐video monitoring at least one...
The pathophysiology of epilepsy underlies a complex network dysfunction between neurons and glia, the molecular cell type-specific contributions which remain poorly defined in human disease. In this study, we validated method that simultaneously isolates neuronal (NEUN +), astrocyte (PAX6 + NEUN-), oligodendroglial progenitor (OPC) (OLIG2 NEUN-) enriched nuclei populations from non-diseased, fresh-frozen neocortex then applied it to characterize distinct transcriptomes such isolated...
The validity of brain monitoring using electroencephalography (EEG), particularly to guide care in patients with acute or critical illness, requires that experts can reliably identify seizures and other potentially harmful rhythmic periodic activity, collectively referred as "ictal-interictal-injury continuum" (IIIC). Previous interrater reliability (IRR) studies are limited by small samples selection bias. This study was conducted assess the identifying IIIC.
Direct electrical stimulation (DES) is sometimes used in epilepsy surgery to identify areas that may result language deficits if resected. Extraoperative mapping usually performed using electrocorticography (ECOG) — grids and strip electrodes; however, given the better safety profile of stereoelectroencephalogaphy (SEEG), it would be desirable determine SEEG also effective. We report a case series fifteen patients underwent with either ECOG (5), (9), or both (1). Six group resection ablation...
Brief potentially ictal rhythmic discharges (B(I)RDs) have been described in neonates and critically ill adults, their association with seizures has demonstrated. Their significance noncritically adults remains unclear. We aimed to investigate prevalence, electrographic characteristics, clinical significance.We identified adult patients B(I)RDs who received long-term EEG recordings either the epilepsy monitoring unit or ambulatory setting. Patients acute findings on imaging status...
<h3>Importance</h3> Limbic encephalitis that is associated with anti–voltage-gated potassium channel complex (VGKCC) antibodies (VGKCC syndrome) an autoimmune, usually nonparaneoplastic form of responsive to immunotherapy. Differentiating this treatable disease from others have a similar presentation thus important. <h3>Observations</h3> We present the case 58-year-old man who had rapid onset progressive confusion, twitching face and hand, abnormal basal ganglia detected by magnetic...
Abstract Objective The electroencephalographic (EEG) terms “brief potentially ictal rhythmic discharges” (BIRDs) and “paroxysmal fast activity” (PFA) are considered distinct entities; however, their definitions overlap, they may have similar clinical significance. We investigated significance association with seizures the seizure onset zone (SOZ). Methods retrospectively identified an adult cohort (July 2015 to March 2018) whose long‐term (>12 h) EEGs in any setting reported BIRDs (>4...