A5007690936- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- EEG and Brain-Computer Interfaces
- Neuroscience and Neuropharmacology Research
- Functional Brain Connectivity Studies
- Neural dynamics and brain function
- Pregnancy and Medication Impact
- Diet and metabolism studies
- Neonatal and fetal brain pathology
- Photoreceptor and optogenetics research
- Blind Source Separation Techniques
- Traumatic Brain Injury and Neurovascular Disturbances
- Advanced MRI Techniques and Applications
- Palliative Care and End-of-Life Issues
- Cardiac Arrest and Resuscitation
- Neurological Complications and Syndromes
- Acute Ischemic Stroke Management
- Infectious Encephalopathies and Encephalitis
- Pharmaceutical studies and practices
- Metabolism and Genetic Disorders
- Alzheimer's disease research and treatments
- Intensive Care Unit Cognitive Disorders
- Maternal Mental Health During Pregnancy and Postpartum
- Neurosurgical Procedures and Complications
- Ion channel regulation and function
Johns Hopkins University
2016-2025
Johns Hopkins Medicine
2016-2025
Montana State University
2025
National Heart Lung and Blood Institute
2024
Johns Hopkins Hospital
2005-2024
Newcastle University
2021-2024
Los Angeles Medical Center
2024
Johns Hopkins Bayview Medical Center
2017-2023
Mayo Clinic in Florida
2020-2023
University of Kentucky
2020-2023
The incidence of epilepsy is higher in older age than at any other period life. Stroke, dementia, and hypertension are associated with late-onset epilepsy; however, the role vascular lifestyle factors remains unclear.To identify midlife risk for epilepsy.The Atherosclerosis Risk Communities (ARIC) study a prospective cohort 15 792 participants followed up since 1987 to 1989 in-person visits, telephone calls, surveillance hospitalizations (10 974 invited without completing enrollment). ARIC...
The Virtual Brain (TVB) is now available as open-source services on the cloud research platform EBRAINS (ebrains.eu). It offers software for constructing, simulating and analysing brain network models including TVB simulator; magnetic resonance imaging (MRI) processing pipelines to extract structural functional networks; combined simulation of large-scale networks with small-scale spiking automatic conversion user-specified model equations into fast code; simulation-ready patients healthy...
Seizures (SZs) and other SZ-like patterns of brain activity can harm the contribute to in-hospital death, particularly when prolonged. However, experts qualified interpret EEG data are scarce. Prior attempts automate this task have been limited by small or inadequately labeled samples not convincingly demonstrated generalizable expert-level performance. There exists a critical unmet need for an automated method classify SZs events with reliability. This study was conducted develop validate...
<h3>Objective</h3> To compare the proportions of unintended pregnancies, prenatal vitamin or folic acid (PNVF) use, adequate care visits, and breastfeeding among women with epilepsy (WWE) to without (WWoE). <h3>Methods</h3> The Pregnancy Risk Assessment Monitoring System (PRAMS) is an annual survey randomly sampled postpartum administered by Centers for Disease Control Prevention. We used PRAMS data from 13 states 2009 2014 primary outcomes in WWE WWoE, as well our secondary contraception...
<h3>Objective</h3> To determine the risk of dementia after development late-onset epilepsy. <h3>Methods</h3> We used data from Atherosclerosis Risk in Communities (ARIC) cohort study, which started 1987 to 1989 with 15,792 mostly Black and White men women 4 US communities. identified epilepsy (LOE; seizures starting at age 67 or later) linked Medicare claims data. a Cox proportional hazards regression model evaluate associations between LOE through 2017 as ascertained neuropsychological...
<h3>Importance</h3> The neurodevelopmental risks of fetal exposure are uncertain for many antiseizure medications (ASMs). <h3>Objective</h3> To compare children at 2 years age who were born to women with epilepsy (WWE) vs healthy and assess the association maximum ASM in third trimester subsequent cognitive abilities among WWE. <h3>Design, Setting, Participants</h3> Maternal Outcomes Neurodevelopmental Effects Antiepileptic Drugs (MONEAD) study is a prospective, observational, multicenter...
The treatment of carbapenem-resistant Acinetobacter baumannii/calcoaceticus complex (CRAB) presents significant challenges.
Propylene glycol is a solvent commonly used in drug preparation. Although generally considered nontoxic, there are reports of toxic effects animals and humans. Noted have included seizures, sudden collapse, cardiac arrythmia asystole, hepatic damage, renal hemolysis, serum hyperosmolality with marked osmolar gap. We previously reported small premature infants receiving large dose propylene during IV nutrition. The major source for these was an multivitamin solution, MVI-12 (Armour...
Treatment of medically intractable focal epilepsy (MIFE) by surgical resection the epileptogenic zone (EZ) is often effective provided EZ can be reliably identified. Even with use invasive recordings, clinical differentiation between and normal brain areas quite challenging, mainly in patients without MRI detectable lesions. Consequently, despite relatively large regions being removed, success rates barely reach 60-65%. Such variable unfavorable outcomes associated high morbidity are caused...
ObjectiveTo identify the association between brain vascular changes and cortical volumes on MRI late-onset epilepsy. MethodsIn 1993-1995, 1,920 participants (median age 62.7, 59.9% female) in community-based Atherosclerosis Risk Communities (ARIC) Study underwent MRI, white matter hyperintensities were measured.In addition, 2011-2013, 1,964 ARIC 72.4,61.1% measured.We identified cases of epilepsy (starting at 60 or later) from hospitalization records Medicare claims data.Using 1993-1995 we...
<h3>Objective:</h3> To compare specific life stressors and domestic abuse that pregnant women with epilepsy (WWE) experience compared to without (WWoE). <h3>Methods:</h3> The Pregnancy Risk Assessment Monitoring System (PRAMS) is an annual weighted survey of randomly sampled postpartum administered by the Centers for Disease Control (CDC). We used data from PRAMS 2012-2020 in 13 states assess reported WWE WWoE. adjusted maternal age, race, ethnicity, marital status, education, socioeconomic...
<h3>Background and Objectives</h3> The objective of this study was to determine the relationship between plasma β-amyloid (Aβ), specifically ratio 2 Aβ peptides (the Aβ<sub>42</sub>/Aβ<sub>40</sub> ratio, which correlates with increased accumulation in CNS), late-onset epilepsy (LOE). <h3>Methods</h3> We used Medicare fee-for-service claims codes from 1991 2018 identify cases LOE among 1,424 Black White men women enrolled Atherosclerosis Risk Communities (ARIC) cohort. calculated samples...
Importance Although both head injury and epilepsy are associated with long-term dementia risk, posttraumatic (PTE) has only been evaluated in association short-term cognitive outcomes. Objective To investigate associations of PTE risk. Design, Setting, Participants The Atherosclerosis Risk Communities (ARIC) study initially enrolled participants from 1987 to 1989 this prospective cohort uses data through December 31, 2019, a median follow-up 25 years. Data were analyzed between March 14,...
Abstract Operators often look to use drill pipe rotation increase hole cleaning effectiveness in horizontal and high-angle sections of wellbores. However, the effect on cuttings transport is dependent a range factors, from fluid rheology density, rate, diameter, diameter. To identify cause these parameters, several multiphase flow simulations were performed possible changes regimes that would affect efficiency. Computational Fluid Dynamics (CFD) software was utilized develop simulate single...