A5004916069- Epilepsy research and treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Traumatic Brain Injury Research
- Functional Brain Connectivity Studies
- EEG and Brain-Computer Interfaces
- Pharmacological Effects and Toxicity Studies
- Schizophrenia research and treatment
- Neural dynamics and brain function
- Advanced Neuroimaging Techniques and Applications
- Neonatal and fetal brain pathology
- Advanced MRI Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Heart Rate Variability and Autonomic Control
- Cardiac Arrest and Resuscitation
- Takotsubo Cardiomyopathy and Associated Phenomena
- Electroconvulsive Therapy Studies
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Syncope and Autonomic Disorders
- Infectious Encephalopathies and Encephalitis
- ECG Monitoring and Analysis
- Cerebrospinal fluid and hydrocephalus
- Intensive Care Unit Cognitive Disorders
- Atrial Fibrillation Management and Outcomes
- Sleep and related disorders
- Head and Neck Surgical Oncology
University of Pennsylvania
2021-2024
California University of Pennsylvania
2021-2024
Hospital of the University of Pennsylvania
2020-2024
University of Miami
2022
University of Utah
2022
Yale University
2022
University of Pittsburgh
2022
Philadelphia University
2022
Penn Presbyterian Medical Center
2022
Johns Hopkins Medicine
2018-2021
Abstract Objective Interictal spikes help localize seizure generators as part of surgical planning for drug‐resistant epilepsy. However, there are often multiple spike populations whose frequencies change over time, influenced by brain state. Understanding state changes in rates will improve our ability to use planning. Our goal was determine the effect sleep and seizures on interictal spikes, seizure‐related seizure‐onset zone (SOZ). Methods We performed a retrospective analysis...
Posttraumatic epilepsy (PTE) is a recognized sequela of traumatic brain injury (TBI), but the long-term outcomes associated with PTE independent severity are not precisely known.To determine incidence, risk factors, and association functional self-reported somatic, cognitive, psychological concerns in large, prospectively collected TBI cohort.This multicenter, prospective cohort study was conducted as part Transforming Research Clinical Knowledge Traumatic Brain Injury identified patients...
Neuroimaging correlates of remote traumatic brain injury (TBI) are not well understood. Our objective was to examine associations TBI with MRI markers degeneration and vascular disease. We performed a cross-sectional analysis using data from subset participants who underwent 3T during the fifth Atherosclerosis Risk in Communities Study visit 2011-2013. Prior age at first (<18 years, 18-65 >65 years) defined self-report International Classification Diseases, Ninth Edition code data. examined...
Dysfunction of the blood-brain-barrier (BBB) is a recognized pathological consequence traumatic brain injury (TBI) which may play an important role in chronic TBI pathophysiology. We hypothesized that BBB disruption can be detected with dynamic contrast-enhanced (DCE) MRI not only association focal lesions but also normal-appearing tissue patients, reflecting microscopic microvascular injury. further integrity would improve completely normalize months after TBI.DCE was performed 40 adult...
Functional gradients have been used to study differences in connectivity between healthy and diseased brain states, however this work has largely focused on the cortex. Because subcortex plays a key role seizure initiation temporal lobe epilepsy (TLE), subcortical functional-connectivity may help further elucidate brains TLE, as well left (L)-TLE right (R)-TLE. In work, we calculated (SFGs) from resting-state functional MRI (rs-fMRI) by measuring similarity profiles of voxels cortical gray...
Importance Although both head injury and epilepsy are associated with long-term dementia risk, posttraumatic (PTE) has only been evaluated in association short-term cognitive outcomes. Objective To investigate associations of PTE risk. Design, Setting, Participants The Atherosclerosis Risk Communities (ARIC) study initially enrolled participants from 1987 to 1989 this prospective cohort uses data through December 31, 2019, a median follow-up 25 years. Data were analyzed between March 14,...
Traumatic brain injury results in diffuse axonal and the ensuing maladaptive alterations network function are associated with incomplete recovery persistent disability. Despite importance of as an endophenotype TBI, there is no biomarker that can measure aggregate region-specific burden injury. Normative modeling emerging quantitative case-control technique capture deviations networks at individual patient level. Our objective was to apply normative TBI study after primarily complicated mild...
Understanding risk for epilepsy among persons who sustain a mild (mTBI) traumatic brain injury (TBI) is crucial effective intervention and prevention. However, mTBI frequently undocumented or poorly documented in health records. Further, records are non-continuous, such as when move through systems (e.g., from Department of Defense to Veterans Affairs [VA] between jobs the civilian sector), making population-based assessments this relationship challenging. Here, we introduce MINUTE (Military...
Evaluating patients with drug-resistant epilepsy often requires inducing seizures by tapering antiseizure medications (ASMs) in the monitoring unit (EMU). The relationship between ASM taper strategy, seizure timing, and severity remains unclear. In this study, we developed validated a pharmacokinetic model of total load tested its association occurrence EMU.We studied 80 who underwent intracranial electroencephalographic recording for surgery planning. We first order ASMs administered EMU to...
Epilepsy is defined by the occurrence of multiple unprovoked seizures, but quality life (QOL) in people with epilepsy determined factors, which psychiatric comorbid conditions play a pivotal role. Therefore, understanding interplay between and QOL across phenotypes an important step toward improved outcomes. Here, we report impact distinct cohort post-9/11 veterans high rates traumatic brain injury (TBI).This observational study from Veterans Health Administration included epilepsy. A...
Traumatic brain injury (TBI) is a major public health problem. Caused by external mechanical forces, characteristic of TBI the shearing axons across white matter, which causes structural connectivity disruptions between regions. This diffuse leads to cognitive deficits, frequently requiring rehabilitation. Heterogeneity another as severity and sequelae disease have wide variation patients, posing big challenge for treatment. Thus, measures assessing network-wide in are necessary quantify...
Background The piriform cortex has been implicated in the initiation, spread and termination of epileptic seizures. This understanding extended to surgical management epilepsy, where it shown that resection or ablation can result better outcomes. How why may play such a crucial role seizure networks is not well understood. To answer these questions, we investigated functional structural connectivity both healthy controls temporal lobe epilepsy (TLE) patients. Methods We studied retrospective...
Introduction: The authors tested the hypothesis that EEG feature generalized polyspike train (GPT) is associated with drug-resistant idiopathic epilepsy (IGE). Methods: conducted a single-center case–control study of patients IGE who had outpatient EEGs performed between 2016 and 2020. classified as or drug-responsive based on clinical review in masked manner reviewed data for presence timing GPT (a burst rhythmic spikes lasting less than 1 second) other features. A relationship drug...
Abstract Objective To determine the association between brain MRI abnormalities and incident epilepsy in older adults. Methods Men women (ages 45–64 years) from Atherosclerosis Risk Communities study were followed up 1987 to 2018 with performed 2011 2013. We identified cases of late‐onset (LOE) onset seizures occurring after acquisition MRI. evaluated relative pattern cortical thickness, subcortical volume, white matter integrity among participants LOE comparison without seizures. examined...
Objectives The aim of the study was to report a case patient who experienced fatal aneurysmal subarachnoid hemorrhage during course electroconvulsive therapy (ECT). Methods This is and review literature. Results Electroconvulsive widely viewed as safe effective treatment for major depressive disorder; however, there remains some uncertainty regarding safety ECT in patients with cerebral aneurysms. Many cases exist documenting both secured unsecured aneurysms; these had aneurysms that were...
Objective: To describe a case of flecainide-induced delirium associated with pharmacokinetic drug interaction paroxetine. Case Summary: A 69-year-old white female presented to the emergency department history confusion and paranoia over past several days. On admission patient was taking carvedilol 12 mg twice daily, warfarin 2 mg/day, folic acid 1 levothyroxine 100 μg/day, pantoprazole 40 paroxetine flecainide daily. Flecainide had been started weeks prior for atrial fibrillation. Laboratory...