A5007667325- Traumatic Brain Injury Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac Arrest and Resuscitation
- Trauma and Emergency Care Studies
- Vestibular and auditory disorders
- Photoreceptor and optogenetics research
- Musculoskeletal pain and rehabilitation
- Neuroscience of respiration and sleep
- Hearing, Cochlea, Tinnitus, Genetics
- Migraine and Headache Studies
- Ophthalmology and Eye Disorders
- Anesthesia and Neurotoxicity Research
- Emergency and Acute Care Studies
- Chronic Disease Management Strategies
- Posttraumatic Stress Disorder Research
- Heart Rate Variability and Autonomic Control
- Retinal Development and Disorders
- Spinal Cord Injury Research
- Frailty in Older Adults
- Epilepsy research and treatment
- Neuropeptides and Animal Physiology
- Dementia and Cognitive Impairment Research
- Cardiac Ischemia and Reperfusion
- Nicotinic Acetylcholine Receptors Study
- S100 Proteins and Annexins
South Texas Veterans Health Care System
2016-2024
The University of Texas at San Antonio
2019-2024
Google (United States)
2020-2023
East Tennessee State University
2021
James H. Quillen VA Medical Center
2021
Appalachian State University
2020
The University of Texas Health Science Center at San Antonio
2016-2020
University of Utah
2020
Lees McRae College
2020
VA Salt Lake City Healthcare System
2020
1. 5‐Hydroxytryptamine (HT) caused vasoconstriction and bronchoconstriction in cats' lungs perfused with blood. These actions were antagonized by dihydroergotamine or lysergic acid diethylamide. 2. The HT‐equivalent of the plasma was estimated extraction acetone assay on rat's uterus comparison synthetic HT. This low immediately after bleeding, but rose rapidly to about 1 mg. per litre. 3. fell exponentially during perfusion a halving time 4‐20 min. 4. When rate circulation increased...
Recent theories posit that adult neurogenesis supports dentate gyrus pattern separation and hence is necessary for some types of discrimination learning. Using an inducible transgenic mouse model, we investigated the contribution adult-born neurons to spatial nonspatial touch-screen discriminations varying levels difficulty. Arresting caused a modest but statistically significant impairment in position task. However, effect was present only on trials after learned reversed, suggesting...
The purpose of this study was to describe the prevalence hearing loss and tinnitus in a cohort Iraq Afghanistan Veterans (IAV) with common post-deployment conditions, including traumatic brain injury (TBI), post-traumatic stress disorder (PTSD), other typical post-concussive conditions such as headaches vertigo/dizziness. This retrospective observational used data from national Health Administration (VA) repository fiscal years 2001-2014. Veteran included if there were at least three VA...
Objectives: To identify and validate trajectories of comorbidity associated with traumatic brain injury in male female Iraq Afghanistan war Veterans (IAV).Methods: Derivation validation cohorts were compiled IAV who entered the Department Affairs (VA) care received 3 years VA between 2002–2011. Chronic disease comorbidities deployment including TBI identified using diagnosis codes. A latent class analysis (LCA) longitudinal data was used to comorbidity.Results: LCA revealed five that similar...
1. The distribution of specific and non‐specific cholinesterases in the retina optic nerve rabbit has been studied by Koelle's histochemical method. 2. Specific cholinesterase was detected bipolar ganglion cells but not rods cones or nerve. 3. Non‐specific glial septa nuclei cell layers.
Microarray-based transcriptional profiling was used to determine the effect of progesterone in cortical contusion (CCI) model. Gene ontology (GO) analysis then evaluated dose on relevant biological pathways. Treatment (vehicle, 10 mg/kg or 20 given i.p.) started 4 h post-injury and administered every 12 for up 72 h, with last injection hr prior death 24 groups. In CCI-injured vehicle group compared non-injured animals, expression 1,114, 4,229, 291 distinct genes changed >1.5-fold (p<0.05) at...
Because of changes in demography and the emphasis on diversity programming, organizational leaders need to understand how employees' empathy toward diverse groups affects program perceptions. This study examines whether individual ethnic/cultural relates intentions attend interest initiatives. The sample consisted 294 college students at a moderate sized Midwestern University. There were significant relationships found. Women those higher reported behavioral positive perceptions programs....
Mild traumatic brain injury in the Veteran population is frequently comorbid with pain, post-traumatic stress disorder, and/or depression. However, not everyone exposed to mild experiences these comorbidities and it unclear what factors contribute this variability. The objective of study was identify comorbidity phenotypes among Post-9/11 deployed Veterans no or examine association adverse outcomes. We found that (n = 93,003) 434,378) were mean age 32.0 (SD 9.21) on entering Department...
The chronic mental health consequences of mild traumatic brain injury (TBI) are a leading cause disability. This is surprising given the expectation significant recovery after TBI, which suggests that other injury-related factors may contribute to long-term adverse outcomes. objective this study was determine how number prior injuries, gender, and environment/context depressive symptoms TBI among deployed United States service members veterans (SMVs). Data from Long-term Impact...
Age is a consistent predictor of poor outcome following traumatic brain injury (TBI). Although the elderly population has one highest rates TBI-related hospitalization and death, few preclinical studies have attempted to model treat TBI in aged population. Recent indicated that nicotinamide (NAM), soluble B-group vitamin, improved functional recovery experimental models young animals. The purpose present study was examine efficacy NAM middle-aged rats. Groups (14-month-old) rats were...
Objectives: To examine long-term outcomes of self-reported physical and mental health among Post-9/11 Veterans stratified by traumatic brain injury (TBI) severity, we hypothesized that more severe TBI would be associated with significantly poorer outcomes.Methods: A prospective longitudinal survey status was conducted a national cohort Veterans. We then used generalized linear models (GLM) to assess the unique contribution severity on after controlling for socio-demographic characteristics,...
Objective To determine the validity of diagnoses indicative early-onset dementia (EOD) obtained from an algorithm using administrative data, we examined Veterans Health Administration (VHA) electronic medical records (EMRs).Method A previously used method identifying cases data was applied to a random sample 176 Post-9/11 deployed veterans under 65 years age. Retrospective, cross-sectional examination EMRs conducted, combination chart abstraction, and review/consensus by board-certified...
Objectives: To describe the prevalence of sensory dysfunction (i.e. auditory, visual, vestibular, chemosensory and multiple problems) explore associations with traumatic brain injury (TBI) severity mechanism among deployed Post-9/11 Veterans.Methods: This retrospective cohort analysis used Departments Defense Veterans Affairs diagnostic codes administrative data.Results: Among 570,248 in this cohort, almost 23% had at least one diagnosis dysfunction. In multinomial regression analysis, odds...
Understanding risk for epilepsy among persons who sustain a mild (mTBI) traumatic brain injury (TBI) is crucial effective intervention and prevention. However, mTBI frequently undocumented or poorly documented in health records. Further, records are non-continuous, such as when move through systems (e.g., from Department of Defense to Veterans Affairs [VA] between jobs the civilian sector), making population-based assessments this relationship challenging. Here, we introduce MINUTE (Military...
Hearing loss is the second most common disability awarded by U.S. Department of Veterans Affairs (VA) to former members uniformed services. readiness and conservation practices differ among four largest military services (Air Force, Army, Marine Corps, Navy). Utilizing a data set consisting all hearing claims submitted VA from fiscal years 2003-2013, we examined characteristics veterans submitting within one year separation service. Our results indicate that having claim granted was...
Purpose To describe the prevalence of communication disorders in a cohort 84,377 deployed post-9/11 veterans stratified by blast traumatic brain injury (TBI) exposure. Secondary aim was to evaluate association between postconcussion symptoms, such as posttraumatic stress disorder, depression, anxiety, insomnia, pain, headache, substance use and auditory problems, among with without disorder diagnosis. Method This is retrospective study aphasia, apraxia speech dysarthria,...
To describe the prevalence and impact of vestibular dysfunction nonspecific dizziness diagnoses explore their associations with traumatic brain injury (TBI) severity, mechanism, postconcussive comorbidities among post-9/11 veterans.
To examine and categorize symptoms occurring within 60 s of vertebrobasilar-insufficiency (VBI) testing (left- right-neck rotation) in individuals with persistent post-traumatic headache.As part routine clinical cervical screening our patients, we found extended VBI often triggered additional symptoms. Therefore, aimed to document the prevalence precise during each movement direction this test determine any demographic or baseline signs associated a positive test.A retrospective medical...
1. The carotid sinus in cats, isolated from the rest of circulation but with its nerve supply intact, was perfused ether and chloroform various concentrations buffered Tyrode solution. increased sensitivity baroreceptors which these anæsthetics produce is great enough to cause reflex changes systemic blood pressure heart rate under conditions. 2. Perfusion high (300 mg. per cent W/V) (100 rapidly inactivated baroreceptors. 3. fall produced by sudden inhalation ether, trichlorethylene...
Objective: To evaluate whether neurobehavioral symptoms differ between groups of veterans with mild traumatic brain injury (mTBI) classified by health characteristics. Participants: A total 71 934 post-9/11 mTBI from the Chronic Effects Neurotrauma Consortium Epidemiology warfighter cohort. Design: Cross-sectional analysis retrospective Main Measures: Health phenotypes identified using latent class and function over 5 years. Symptom severity measured Neurobehavioral Inventory; domains...
Objectives To compare sub-occipital muscle pressure sub pain thresholds (PPTs) in individuals with persistent-post-traumatic-headache (PPTH) relation to the presence or not of cranial nerve and/or autonomic symptoms reported during sustained neck rotation (SNR).