A5101864357- Traumatic Brain Injury Research
- Cardiac Arrest and Resuscitation
- Musculoskeletal pain and rehabilitation
- Traumatic Brain Injury and Neurovascular Disturbances
- Trauma and Emergency Care Studies
- Migraine and Headache Studies
- Posttraumatic Stress Disorder Research
- Chronic Disease Management Strategies
- Suicide and Self-Harm Studies
- Machine Learning in Healthcare
- Artificial Intelligence in Healthcare
- Bioinformatics and Genomic Networks
- Opioid Use Disorder Treatment
- Amyotrophic Lateral Sclerosis Research
- Advanced Neuroimaging Techniques and Applications
- Epilepsy research and treatment
- Pain Management and Opioid Use
- Advanced MRI Techniques and Applications
- Pediatric Pain Management Techniques
- Stuttering Research and Treatment
- Silk-based biomaterials and applications
- Health and Medical Research Impacts
- Muscle Physiology and Disorders
- Pregnancy-related medical research
- Developmental Biology and Gene Regulation
South Texas Veterans Health Care System
2014-2023
The University of Texas Health Science Center at San Antonio
2014-2023
Veterans Health Administration
2017
Geriatric Research Education and Clinical Center
2014
Audie L. Murphy Memorial VA Hospital
2013
University of Chicago
2001
The purpose of this study was to describe the prevalence hearing loss and tinnitus in a cohort Iraq Afghanistan Veterans (IAV) with common post-deployment conditions, including traumatic brain injury (TBI), post-traumatic stress disorder (PTSD), other typical post-concussive conditions such as headaches vertigo/dizziness. This retrospective observational used data from national Health Administration (VA) repository fiscal years 2001-2014. Veteran included if there were at least three VA...
To examine the association of epilepsy with traumatic brain injury (TBI) in Afghanistan and Iraq (Operation Enduring Freedom [OEF]/Operation Iraqi [OIF]) Veterans.Cross-sectional observational study.A total 256 284 OEF/OIF Veterans who received inpatient outpatient care Health Administration fiscal years 2009-2010.We used algorithms developed for use International Classification Diseases, Ninth Revision, Clinical Modification, codes to identify epilepsy, TBI (penetrating [pTBI]/other TBI),...
Objectives: To identify and validate trajectories of comorbidity associated with traumatic brain injury in male female Iraq Afghanistan war Veterans (IAV).Methods: Derivation validation cohorts were compiled IAV who entered the Department Affairs (VA) care received 3 years VA between 2002–2011. Chronic disease comorbidities deployment including TBI identified using diagnosis codes. A latent class analysis (LCA) longitudinal data was used to comorbidity.Results: LCA revealed five that similar...
<h3>Importance</h3> Posttraumatic headache is the most disabling complication of mild traumatic brain injury. stress disorder (PTSD) symptoms are often comorbid with posttraumatic headache, and there no established treatments for this comorbidity. <h3>Objective</h3> To compare cognitive behavioral therapies (CBTs) PTSD treatment per usual (TPU) attributable to <h3>Design, Setting, Participants</h3> This was a single-site, 3–parallel group, randomized clinical trial outcomes at posttreatment,...
Pair-rule genes were identified and named for their role in segmentation embryos of the long germ insect Drosophila. Among short insects these exhibit variable expression patterns during thus are likely to play divergent roles this process. Understanding details variation should shed light on evolution genetic hierarchy responsible Drosophila other insects. We have investigated homologs Pax group III paired, gooseberry gooseberry-neuro flour beetles grasshoppers. During embryogenesis, paired...
Objectives To describe the prevalence and persistence of headache associated conditions in an inception cohort U.S. veterans Iraq Afghanistan wars. Background war (IAV) suffer from persistent difficult‐to‐treat headaches that have been found to co‐occur with traumatic brain injury (TBI) other deployment related comorbidities. Methods This longitudinal retrospective study used data national Veterans Health Administration (VA) repository for IAV who first received VA care 2008 (baseline) also...
The increase in the quantities of central nervous system (CNS)-acting medications prescribed has coincided with increases overdose mortality, suicide-related behaviors, and unintentional deaths military personnel deployed support wars Iraq Afghanistan. Data on extent impact prescribing multiple CNS drugs among Afghanistan Veterans (IAVs) are sparse. We sought to identify characteristics IAVs polypharmacy examine association drug behaviors controlling for known risk factors. This...
Elevated reactive oxygen species (ROS) production and ROS-dependent protein damage is a common observation in the pathogenesis of many muscle wasting disorders, including sarcopenia. However, contribution elevated ROS levels to –a breakdown neuromuscular communication atrophy remains unknown. In this study, we examined copper zinc superoxide dismutase [CuZnSOD (Sod1)] knockout mouse (Sod1−/−), model oxidative stress that exhibits accelerated loss mass, which recapitulates phenotypes...
Research from the wars in Afghanistan and Iraq have focused on traumatic brain injury (TBI) mental health conditions; however, it is becoming clear that other concerns, such as respiratory illnesses, warrant further scientific inquiry. Early reports theater postdeployment assessments suggested an association with deployment-related exposures (e.g., sand, burn pits, chemical, etc.) new-onset symptoms. We used data Veterans Affairs medical encounters between fiscal years 2003 2011 to identify...
Mild traumatic brain injury in the Veteran population is frequently comorbid with pain, post-traumatic stress disorder, and/or depression. However, not everyone exposed to mild experiences these comorbidities and it unclear what factors contribute this variability. The objective of study was identify comorbidity phenotypes among Post-9/11 deployed Veterans no or examine association adverse outcomes. We found that (n = 93,003) 434,378) were mean age 32.0 (SD 9.21) on entering Department...
Objective: To describe the prevalence of communication disorders in veterans wars Iraq and Afghanistan with traumatic brain injury (TBI).Design: Retrospective study aphasia, fluency voice among different severity levels TBI. Data was obtained from VA National repository for OEF/OIF/OND who received care Fiscal Years 2010 2011.Results: Among 303 716 this study, 1848 were diagnosed a disorder; 40% these also Voice most prevalent diagnosis (3.5 per 1000) followed by aphasia (1.9 disorder (0.7...
Objectives: To examine long-term outcomes of self-reported physical and mental health among Post-9/11 Veterans stratified by traumatic brain injury (TBI) severity, we hypothesized that more severe TBI would be associated with significantly poorer outcomes.Methods: A prospective longitudinal survey status was conducted a national cohort Veterans. We then used generalized linear models (GLM) to assess the unique contribution severity on after controlling for socio-demographic characteristics,...
Summary Objectives: Evolution of multiple chronic conditions (MCC) follows a complex stochastic process, influenced by several factors including the inter-relationship existing conditions, and patient-level risk factors. Nearly 20% citizens aged 18 years older are burdened with two or more (multiple) (MCC). Treatment for people living MCC currently accounts an estimated 66% Nation’s healthcare costs. However, it is still not known precisely how emerge accumulate among individuals in general...
Over the past few decades, rise of multiple chronic conditions has become a major concern for clinicians. However, it is still not known precisely how emerge among patients. We propose an unsupervised multi-level temporal Bayesian network to provide compact representation relationship emergence and patient level risk factors over time. To improve efficiency learning process, we use extension maximum weight spanning tree algorithm greedy search study structure proposed in three stages,...
Traumatic brain injury (TBI) is a significant cause of morbidity in military Veterans and Service Members. While most individuals recover fully from mild injuries within weeks, some continue to experience symptoms including headaches, disrupted sleep, other cognitive, behavioral or physical symptoms. Diffusion magnetic resonance imaging (dMRI) shows promise identifying areas structural disruption predicting outcomes. Although studies suggest widespread after injury, dMRI have yielded mixed...
Understanding risk for epilepsy among persons who sustain a mild (mTBI) traumatic brain injury (TBI) is crucial effective intervention and prevention. However, mTBI frequently undocumented or poorly documented in health records. Further, records are non-continuous, such as when move through systems (e.g., from Department of Defense to Veterans Affairs [VA] between jobs the civilian sector), making population-based assessments this relationship challenging. Here, we introduce MINUTE (Military...
Chronic musculoskeletal pain is a complex problem, particularly for individuals with head injury and comorbid psychiatric conditions. The Fear Avoidance Model offers one of the strongest opportunities to conceptualize traumatic pain, but this model largely untested.This study tests chronic using sample from polytrauma patients in large Department Veterans Affairs facility who participated federally-funded interdisciplinary management.The present comprises secondary analysis 93 veterans...
Posttraumatic headache (PTH) is a common debilitating condition arising from head injury and highly prevalent among military service members veterans with traumatic brain (TBI). Diagnosis treatment for PTH still evolving, surprisingly little known about the putative mechanisms that drive these headaches. This manuscript describes design of randomized clinical trial two nonpharmacological (i.e., behavioral) interventions posttraumatic headache. Design this required careful consideration...
Determine the association between acquired stuttering (AS), traumatic brain injury (TBI), and post-traumatic stress disorder (PTSD) in a cohort of 309,675 U.S. Iraq Afghanistan veterans. The secondary aim was to determine AS medication patterns for veterans sample. Retrospective study using data from Veterans Health Administration National Repository deployed support combat operations who received care 2010 2011. We identified ICD-9 codes establish AS, TBI, PTSD, controlling demographic...
Background Although concern exists regarding the adverse effects and rate of zolpidem use, especially long-term limited information is available concerning patterns use. Objective To examine prevalence correlates exposure in Iraq Afghanistan Veterans (IAVs). Methods A retrospective cohort study prescriptions was performed with National Health Administration (VHA) data. We gathered national VA inpatient, outpatient, pharmacy data files for IAV’s who received care between fiscal years (FY)...