A5007843658- Epilepsy research and treatment
- EEG and Brain-Computer Interfaces
- Autoimmune Neurological Disorders and Treatments
- Neuroscience and Neuropharmacology Research
- Infectious Encephalopathies and Encephalitis
- Neonatal and fetal brain pathology
- Metabolism and Genetic Disorders
- Diet and metabolism studies
- Functional Brain Connectivity Studies
- Multiple Sclerosis Research Studies
- Pharmacological Effects and Toxicity Studies
- Antibiotics Pharmacokinetics and Efficacy
- Cerebrospinal fluid and hydrocephalus
- Advanced MRI Techniques and Applications
- Ion channel regulation and function
- Organ Donation and Transplantation
- Polyomavirus and related diseases
- Cardiovascular Syncope and Autonomic Disorders
- Cerebral Venous Sinus Thrombosis
- Sepsis Diagnosis and Treatment
- Grief, Bereavement, and Mental Health
- Genetic Neurodegenerative Diseases
- Spinal Fractures and Fixation Techniques
- Intestinal Malrotation and Obstruction Disorders
- Renal and Vascular Pathologies
Johns Hopkins University
2019-2025
Johns Hopkins Medicine
2020-2025
Johns Hopkins Bayview Medical Center
2020-2024
Johns Hopkins Hospital
2019-2024
University of Baltimore
2023
American Academy of Neurology
2020
John Wiley & Sons (United States)
2020
Nihon Kohden (Japan)
2020
The University of Texas Southwestern Medical Center
2017-2019
Southwestern Medical Center
2018
The Salzburg criteria for nonconvulsive status epilepticus (NCSE) and the American Clinical Neurophysiology Society (ACNS) Standardized Critical Care EEG Terminology 2021 include a diagnostic trial with intravenous (IV) antiseizure medications (ASMs) to assess electroencephalographic (EEG) clinical response as criterion definite NCSE possible NCSE. However, how perform this test assessing responses have not been operationally defined.We performed Delphi process involving six experts...
To characterize the present state of brain death (BD) determination in actual practice relative to contemporary American Academy Neurology (AAN) guidelines.We reviewed charts all adult (16 years and older) BD organ donors during 2011 from 68 heterogeneous hospitals Midwest United States. Data were collected across 5 categories: guideline performance, preclinical testing, clinical examination, apnea use ancillary tests. Practice within categories overall adherence AAN guidelines assessed.Two...
Whereas a scalp electroencephalogram (EEG) is important for diagnosing epilepsy, single routine EEG limited in its diagnostic value. Only small percentage of EEGs show interictal epileptiform discharges (IEDs) and overall misdiagnosis rates epilepsy are 20% to 30%. We aim demonstrate how network properties recordings can be used improve the speed accuracy differentiating from mimics, such as functional seizures - even absence IEDs. In this multicenter study, we analyzed 218 patients with...
Objectives: To elucidate etiologies, treatment, functional and neurocognitive outcomes of children with new-onset refractory status epilepticus. Design: A single-center retrospective study. Setting: tertiary care children’s hospital. Patients: All patients between 1 month 21 years old admitted epilepticus January 2004 July 2017. Interventions: None. Measurements Main Results: Clinical presentation, laboratory data, imaging studies, treatments were collected during hospitalization. Outcomes...
Summary: The use of continuous EEG monitoring has expanded in the last decade, allowing recognition not only nonconvulsive seizures but also relatively high prevalence periodic and rhythmic patterns. Periodic discharges are a fairly common pattern often present therapeutic challenge when encountered. We will consider five associations these discharges: ictal, acute seizures, epileptogenic, injurious, epiphenomenal. challenges unanswered questions pertaining to discharges, along with several...
Purpose: To evaluate the clinical and electrographic characteristics of critically ill pediatric patients with lateralized rhythmic delta activity (LRDA) compare them periodic discharges (LPDs). Methods: This was a retrospective study examining consecutive (1 month–18 years) LRDA or LPDs monitored on continuous electroencephalography. Clinical, radiologic, characteristics; disease severity; acute sequelae were compared between two groups. Results: Of 668 electroencephalography during period,...
Purpose: Triphasic waves (TWs) have been associated with a host of medication toxicities, and cefepime has emerged recently as frequently encountered offending agent. This investigation aims to evaluate cefepime-induced encephalopathy report the clinical, EEG expression TWs, radiologic findings. Methods: A retrospective multicenter observational study examining adult patients generalized periodic discharges on either routine or continuous between January 2014 2020. Clinical, electrographic,...
Abstract Objective While scalp EEG is important for diagnosing epilepsy, a single routine limited in its diagnostic value. Only small percentage of EEGs show interictal epileptiform discharges (IEDs) and overall misdiagnosis rates epilepsy are 20-30%. We aim to demonstrate how analyzing network properties recordings can be used improve the speed accuracy diagnosis - even absence IEDs. Methods In this multicenter study, we analyzed from 198 patients with suspected normal initial EEGs. The...
Anesthetic agents have been widely used in the treatment of refractory status epilepticus and medical management increased intracranial pressure whenever goal is therapeutic burst suppression. Periodic patterns typically consisting generalized periodic discharges (GPDs) following emergence from anesthesia described several case reports. However, their clinical significance particular whether these are epileptiform remains unclear.This a single-center, retrospective, observational study...
Çataltepe O, Jallo GI. Pediatric Epilepsy Surgery: Preoperative Assessment and Surgical Treatment. 2nd ed. New York, NY: Thieme Medical Publishers; 2020. ISBN: 9781626238169
Introduction: Acute Encephalitis is associated with a high risk of acute symptomatic seizures, status epilepticus, and remote epilepsy. Ketogenic diet therapies (KDT) have been established as feasible safe adjunctive management refractory- super-refractory epilepticus. However, the role KDT in chronic Post-encephalitic epilepsy (PE) autoimmune-associated (AE) unknown. This study aims to investigate use patients PE AE. Methods: A retrospective single-center case series examining adult AE...
Case reports and case series have described fluorodeoxyglucose (FDG)-PET findings in critically ill patients with rhythmic or periodic EEG patterns, one reporting that metabolic activity increases increasing lateralized discharge (LPD) frequency. However, larger studies examining the relationship between FDG-PET hypermetabolism patterns are lacking. The goal of this study was to investigate association electroencephalographic features neurologic disorders.
Background / Objective Seizures are a complication for pediatric patients requiring extracorporeal membrane oxygenation (ECMO). There no standardized guidelines regarding continuous electroencephalography (EEG) monitoring to detect seizures in these patients, and the impact of protocolized has not been evaluated. Here we examined effects EEG protocol implementation our ECMO population. Methods Retrospective chart reviews were conducted on 57 who underwent concurrent out 165 supported...
Triphasic waves (TWs) have been associated with multiple conditions and adverse outcomes. This study explores the role of white matter disease (WMD) in generation TWs when other common causes these discharges are absent.This is a retrospective case series performed at Johns Hopkins Bayview Medical Center from January 2016 to May 2018, which screened for patients severe WMD, who had on EEG without presence commonly cited provoking factors, including (1) hepatic disease; (2) uremia over...