A5086219002- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Diet and metabolism studies
- Psychosomatic Disorders and Their Treatments
- Hemoglobinopathies and Related Disorders
- Traumatic Brain Injury Research
- Pregnancy and Medication Impact
- Sleep and Wakefulness Research
- Cardiac Arrest and Resuscitation
- Neurological and metabolic disorders
- Neuroscience and Neuropharmacology Research
- Maternal Mental Health During Pregnancy and Postpartum
- Regulation of Appetite and Obesity
- Traumatic Brain Injury and Neurovascular Disturbances
- Adolescent and Pediatric Healthcare
- Bipolar Disorder and Treatment
- EEG and Brain-Computer Interfaces
- Neurological disorders and treatments
- Olfactory and Sensory Function Studies
- Musculoskeletal pain and rehabilitation
- Adenosine and Purinergic Signaling
- Glycogen Storage Diseases and Myoclonus
- Memory and Neural Mechanisms
- Traditional and Medicinal Uses of Annonaceae
- Alkaloids: synthesis and pharmacology
University of Pittsburgh
2011-2024
VA Pittsburgh Healthcare System
2011-2024
South Texas Veterans Health Care System
2008-2023
The University of Texas Health Science Center at San Antonio
2008-2023
VA Salt Lake City Healthcare System
2018-2023
University of Utah
2018-2023
University of Miami
2022
Yale University
2022
University of Pennsylvania
2022
Philadelphia University
2022
The Common Data Element (CDE) Project was initiated in 2006 by the National Institute of Neurological Disorders and Stroke (NINDS) to develop standards for performing funded neuroscience-related clinical research. CDEs are intended standardize aspects data collection; decrease study start-up time; provide more complete, comprehensive, equivalent across studies within a particular disease area. Therefore, will simplify sharing aggregation NINDS-funded research, where appropriate, facilitate...
There have been occasional reports of acute respiratory and skeletal muscle weakness in intensive care unit patients treated with massive doses corticosteroids. However, this setting the concomitant use other drugs may influenced finding. In study effects 5 days treatment high steroids consecutive lung rejection after transplantation were systematically evaluated. Maximal inspiratory pressure during phrenic nerve stimulation peak torque isokinetic contraction quadriceps hamstring muscles...
To identify risk factors for new-onset geriatric epilepsy that may trigger clinicians to consider a differential diagnosis of at symptom onset.Retrospective cohort study.National Veterans Affairs (VA) databases.Veterans aged 66 and older in fiscal year 2000 (FY00) who received VA care FY99 FY00. Individuals with based on validated algorithm constituted the (n=1,843), individuals without (n=1,023,376).Age, sex, race were derived from databases. Clinical conditions associated (e.g.,...
<b>Background: </b> Newer antiepileptic drugs (AEDs) have been shown to be equally efficacious as older seizure medications but with fewer neurotoxic and systemic side effects in the elderly. A growing body of clinical recommendations based on systematic literature review expert opinion advocate use newer agents avoidance phenobarbital phenytoin. This study sought determine if changes practice occurred between 2000 2004—a time during which evidence became increasingly available. <b>Methods:...
Objectives To assess traumatic brain injury (TBI)-related risks factors for early-onset dementia (EOD).Background Younger Post-9/11 Veterans may be at elevated risk EOD due to high rates of TBI in early/mid adulthood. Few studies have explored the longitudinal relationship between (TBI) and emergence subtypes.Methods This matched case-control study used data from Health Administration (VHA) identify with EOD. address low positive predictive value (PPV = 0.27) algorithms VHA records, primary...
Objectives To examine the association between antiepileptic drug ( AED ) receipt and suicide‐related behavior SRB in older veterans. Design Retrospective database analysis. Setting Veterans Health Administration (VHA) inpatient outpatient care. Participants aged 65 2004 to 2006. Measurements was identified using International Classification of Diseases, Ninth Revision, Clinical Modification codes, new monotherapy VHA product variable pharmacy data. Comorbid conditions medications were also...
Epilepsy is defined by the occurrence of multiple unprovoked seizures, but quality life (QOL) in people with epilepsy determined factors, which psychiatric comorbid conditions play a pivotal role. Therefore, understanding interplay between and QOL across phenotypes an important step toward improved outcomes. Here, we report impact distinct cohort post-9/11 veterans high rates traumatic brain injury (TBI).This observational study from Veterans Health Administration included epilepsy. A...
To describe four patients with stimulus-sensitive seizures and myoclonus following severe hypoxic-ischemic injury.In 22 months, adult myoclonus, generalized tonic-clonic, clonic tactile stimulation were identified. EEG hospital records reviewed.EEGs showed bursts of spike polyspike activity associated the clinical seizures. No cerebral was present between epileptiform bursts. At times, prolonged periods suppression recorded. All failed to respond antiepileptic drugs died.Stimulus-sensitive...
Objectives: To compare magnetic resonance spectroscopic imaging (MRSI) findings from the hippocampal regions of military veterans with blast-related mild traumatic brain injury (blast mTBI) and post-traumatic stress disorder (PTSD) to those PTSD only; examine relationship MRSI cognitive neuromotor impairment. Methods: 35 veterans—23 blast mTBI mTBI/PTSD) 12 only participated in study. Whole plane data including N-acetyl asparatate (NAA) choline (Ch) were acquired at 7T for hippocampus....
The age-adjusted prevalence of seizure disorder in United States veterans deployed Iraq and Afghanistan conflicts (IAV) is 6.1 per 1,000 persons (1), compared with 7.1 to 10 the general population (2,3). Persons epilepsy are at risk excess mortality part because comorbidity (4). Although patterns have been associated IAV (5), unique contribution unknown. A cohort study was developed using inpatient, outpatient, pharmacy data from U.S. Department Veterans Affairs, Health Administration (VA)...
Traumatic brain injury (TBI) is a well-established epilepsy risk factor and common among service members. Deployment-related TBI, where combat/blast may be more common, have different outcomes than nondeployment-related TBI. This work examined associations of all TBI exposures (not just combat), epilepsy, while adjusting for comorbidities associated with veterans by deployment status.
.EEG is a valuable tool that assists in the accurate diagnosis of seizure disorders. The precise interpretation EEG requires an ability to recognize patterns are benign nature but may be misinterpreted as indicative tendency. This review will summarize variants encountered adult EEGs including: small sharp spikes, wicket fourteen- and six-hertz positive bursts, spike wave, rhythmic temporal theta bursts drowsiness, subclinical electroencephalographic discharge adults, midline rhythms....
.The antipsychotic agent clozapine (Clozaril®) is reserved for the treatment of refractory psychosis. Clozapine has allowed many schizophrenic patients to lead more independent and productive lives, but its use restricted by side effects. been shown lower seizure threshold produce significant EEG changes. Although not a commonly used drug, both clinical neurophysiology technologists interpreting electroencephalographers need be aware effects on EEG. We review findings two who developed...