A5089355686- Mitochondrial Function and Pathology
- Genetic Neurodegenerative Diseases
- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Pregnancy and preeclampsia studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Functional Brain Connectivity Studies
- Memory and Neural Mechanisms
- Hormonal Regulation and Hypertension
- Pharmacological Effects and Toxicity Studies
- Gestational Diabetes Research and Management
- Drug Transport and Resistance Mechanisms
- Mental Health Research Topics
- Endoplasmic Reticulum Stress and Disease
- Birth, Development, and Health
- Pregnancy and Medication Impact
- Neurological disorders and treatments
Max Planck Institute of Psychiatry
2008-2025
Max Planck Society
2008
Dissection of the HPA axis using single-cell RNA sequencing uncovers adrenal ABCB1 as an important player stress adaptation.
Abstract Background A major research finding in the field of Biological Psychiatry is that symptom-based categories mental disorders map poorly onto dysfunctions brain circuits or neurobiological pathways. Many identified (neuro) biological are “transdiagnostic”, meaning they do not reflect diagnostic boundaries but shared by different ICD/DSM diagnoses. The compromised validity current classification system for impedes rather than supports development treatments only target symptoms also...
Abstract The aim of this project is the validation genomic and non-genomic biomarkers for predicting antidepressant treatment outcome to identify biologically more homogenous subgroups patients that might benefit from specific treatments targeting identified biomarker system. Based on previous findings, we focused stress regulation gene FKBP5 selection a set 41 cytokines/chemokines defining immunological biomarkers. 307 inpatients hospitalized treating major depressive episode were included,...
Purpose The InTraUterine sampling in early pregnancy (ITU) is a prospective cohort study. overarching aim of ITU to unravel genomic, epigenomic, transcriptomic, endocrine, inflammatory and metabolic maternal-placental-fetal mechanisms involved the programming health disease after exposure prenatal environmental adversity, such as maternal malnutrition, cardiometabolic disorders, infections, medical interventions, mental disorders psychosocial stress. This paper describes study protocol,...
ABSTRACT Huntington’s Disease (HD) is strongly associated with psychiatric symptoms, yet, associations between Huntingtin gene ( HTT ) CAG repeat size variations and phenotypes outside the HD complex are still under-investigated. In this genetic case-control study we compared distribution of sizes in predefined ranges patients major depressive disorder (MDD) (n=2136) anxiety disorders (ANX) (n=493), healthy controls (CON) (n=1566). We used regression models to interactions alleles...
Abstract Huntington’s disease (HD) is strongly associated with psychiatric symptoms, yet, associations between huntingtin gene ( HTT ) CAG repeat size variations and phenotypes outside the HD complex are still under-investigated. In this genetic case-control study we compared distribution of sizes in predefined ranges patients major depressive disorder (MDD) n = 2136) anxiety disorders (ANX) 493), healthy controls (CON) 1566). We used regression models to interactions alleles fine-granular...