A5073453446- Autism Spectrum Disorder Research
- Functional Brain Connectivity Studies
- Attention Deficit Hyperactivity Disorder
- Child and Adolescent Psychosocial and Emotional Development
- Schizophrenia research and treatment
- Child Development and Digital Technology
- Fetal and Pediatric Neurological Disorders
- Advanced Neuroimaging Techniques and Applications
- Genetics and Neurodevelopmental Disorders
- Birth, Development, and Health
- Psychosomatic Disorders and Their Treatments
- Breastfeeding Practices and Influences
- Epigenetics and DNA Methylation
- Bipolar Disorder and Treatment
- Neonatal and fetal brain pathology
- Child Nutrition and Feeding Issues
- Genetic Associations and Epidemiology
- Maternal Mental Health During Pregnancy and Postpartum
- Prenatal Screening and Diagnostics
- Pregnancy and preeclampsia studies
- Mental Health Research Topics
- Vitamin D Research Studies
- Health, Environment, Cognitive Aging
- Family and Disability Support Research
- Electroconvulsive Therapy Studies
Amsterdam University Medical Centers
2022-2024
Refaja Ziekenhuis
2024
University of Amsterdam
2022-2023
Erasmus MC - Sophia Children’s Hospital
2015-2023
Erasmus MC
2015-2023
Erasmus University Rotterdam
2016-2023
University of Cambridge
2022
Academic Medical Center
2020
American Academy of Child and Adolescent Psychiatry
2019
Leiden University
2015
The second iteration of the Autism Brain Imaging Data Exchange (ABIDE II) aims to enhance scope brain connectomics research in Spectrum Disorder (ASD). Consistent with initial ABIDE effort I), that released 1112 datasets 2012, this new multisite open-data resource is an aggregate resting state functional magnetic resonance imaging (MRI) and corresponding structural MRI phenotypic datasets. II includes from additional 487 individuals ASD 557 controls previously collected across 16...
There is intense interest in identifying modifiable risk factors associated with autism-spectrum disorders (ASD). Autism-related traits, which can be assessed a continuous fashion, share ASD, and thus serve as informative phenotypes population-based cohort studies. Based on the growing body of research linking gestational vitamin D deficiency altered brain development, this common exposure candidate factor for ASD autism-related traits. The association between measure traits at ~6 years...
Paediatric population neuroimaging is an emerging field that falls at the intersection between developmental neuroscience and epidemiology. A key feature of studies involves large-scale recruitment representative general population. One successful approach for to embed within large epidemiological cohorts. The Generation R Study a large, prospective population-based birth-cohort in which nearly 10,000 pregnant mothers were recruited 2002 2006 with repeated measurements children their parents...
Objective: Psychiatric symptomatology during childhood predicts persistent mental illness later in life. While neuroimaging methodologies are routinely applied cross-sectionally to the study of child and adolescent psychopathology, nature relationship between symptoms underlying neurodevelopmental processes remains unclear. The authors used a prospective population-based cohort delineate longitudinal psychiatric problems brain development. Method: A total 845 children participated study....
Sleep difficulties are prevalent in children with autism spectrum disorder (ASD). The temporal nature of the association between sleep problems and ASD is unclear because longitudinal studies lacking. Our aim to clarify whether precede worsen autistic traits or occur as a consequence disorder. Repeated measures were available at 1.5, 3, 6, 9 years age 5151 participating Generation R Study, large prospective birth cohort Netherlands. Autistic determined Pervasive Developmental Problems score...
Recent advances in neuroimaging techniques have provided significant insights into developmental trajectories of human brain function. Characterizations typical neurodevelopment provide a framework for understanding altered neurodevelopment, including differences function related to disorders and psychopathology. Historically, most functional connectivity studies atypical development operate under the assumption that remains static over time. We hypothesized relaxing stationarity assumptions...
There is growing interest in linking vitamin D deficiency with autism spectrum disorders (ASDs). The association between during gestation, a critical period neurodevelopment, and ASD not well understood.To determine the gestational status ASD.Based on birth cohort (n=4334), we examined 25-hydroxyvitamin (25OHD), assessed from both maternal mid-gestation sera neonatal sera, (defined by clinical records; n=68 cases).Individuals 25OHD-deficient group at had more than twofold increased risk of...
Objective: Recent evidence suggests that symptoms of social impairment in autism spectrum disorder (ASD) form a extends into the general population. However, it is unclear whether neuroanatomy ASD also shows similar continuum Therefore, goal present study was to investigate relationship between cortical morphology and autistic traits along large population-based sample young children. Method: The included 717 children, aged 6–10 years, who are participants Generation R Study, cohort....
Abstract Resting‐state functional magnetic resonance imaging provides a non‐invasive approach to the study of intrinsic brain networks. When applied development, most studies consist relatively small samples that are not always representative general population. Descriptions these networks in population offer important insight for clinical examining, instance, psychopathology or neurological conditions. Thus our goal was characterize resting‐state large sample children using independent...
Although early childhood is a period of rapid neurocognitive development, few studies have assessed neuropsychological functioning in various cognitive domains young typically developing children. Also, results regarding its association with gender and intelligence are mixed. In 853 children aged 6 to 10 years old, the gender, age, attention, executive functioning, language, memory, sensorimotor visuospatial processing was explored. Clear positive associations age were observed. addition,...
Psychiatric symptoms in childhood are closely related to neurocognitive deficits. However, it is unclear whether internalising and externalising associated with general or distinct cognitive problems. We examined the relation between different types of psychiatric functioning a population-based sample 1177 school-aged children. Internalising behaviour was studied both continuously categorically. For continuous, variable-centred analyses, broadband scores were used. these measures strongly...
In a longitudinal population‐based study of 2,905 children, we investigated if infants' neuromotor development was associated with autistic traits in childhood. Overall motor and muscle tone were examined by trained research assistants an adapted version Touwen's Neurodevelopmental Examination between ages 2 5 months. Tone assessed several positions items scored as normal, low, or high tone. Parents rated their children's the Social Responsiveness Scale (SRS) Pervasive Developmental Problems...
Prior studies have shown that psychotic experiences are prospectively associated with an increased risk of suicidality. However, it is unclear whether this association causal or arises from shared factors. Furthermore, little known about the between and non-suicidal self-injury (NSSI). We used data two independent samples young adolescents, which we analyzed separately. In a population-based cohort, on hallucinatory suicidality were collected at ages 10 14 years (N = 3435). cross-sectional...
Objective Adolescent psychotic‐like experiences predict the onset of psychosis, but also subsequent non‐psychotic disorders. Therefore, it is crucial to better understand aetiology experiences. This study examined whether (a) child emotional and behavioural problems at 3 6 years, or (b) childhood adversities were associated with age 10 years. Method prospective was embedded in Generation R Study; 3984 children (mean years) completed a questionnaire. Mothers reported their ages 3,...
Altered trajectories of brain growth are often reported in Autism Spectrum Disorder (ASD), particularly during the first year life. However, less is known about prenatal head trajectories, and no study has examined relation with postnatal autistic symptom severity. The current prospectively association between fetal spectrum severity two large population‐based cohorts, including a sample individuals clinically diagnosed ASD. This included 3,820 children from longitudinal cohorts Netherlands...
Clinical studies of children with autism spectrum disorder (ASD) provide evidence for poorer neuropsychological performance within specific domains compared to age, gender, and sometimes IQ-matched controls. Since recent suggests that autistic symptoms form a extends into the general population, it was our goal evaluate nature relationship between traits across continuum in population. We examined five different 1019 6-to-10-year-old participating population-based study child development....
Abstract A combination of genetic and environmental factors contributes to the origins autism spectrum disorder (ASD). While a number studies have described specific associating with emerging ASD, that compare contrast multiple in same study are lacking. Thus, goal this was perform prospective, data‐driven environmental‐wide association pre‐ perinatal associated later development autistic symptoms childhood. The participants included 3891 6‐year‐old children from birth cohort data. Autistic...
Background Psychotic experiences are common in childhood and an important risk indicator of adverse mental health outcomes. However, little is known about the association psychotic with functional outcomes childhood, particularly regarding school performance. The aim present study was to examine whether were prospectively related performance childhood. Methods This embedded population‐based Generation R Study ( N = 2,362). assessed using self‐reports on hallucinations at age 10 years. School...
Psychotic experiences predict adverse health outcomes, particularly if they are persistent. However, it is unclear what distinguishes persistent from transient psychotic experiences.In a large population-based cohort, we aimed to (a) describe the course of hallucinatory childhood adolescence, (b) compare characteristics youth with and remittent experiences, (c) examine prediction models for persistence.Youth were assessed longitudinally at mean ages 10 14 years (n = 3473)....