A5032995370- Adenosine and Purinergic Signaling
- Bone health and treatments
- Bone health and osteoporosis research
- Adolescent and Pediatric Healthcare
- Neuroendocrine Tumor Research Advances
- Congenital heart defects research
- Botulinum Toxin and Related Neurological Disorders
- Genomic variations and chromosomal abnormalities
- Cardiovascular Issues in Pregnancy
- Genomics and Rare Diseases
- Pharmacological Effects and Toxicity Studies
- Health, Medicine and Society
- Neuroscience of respiration and sleep
- Genetic Neurodegenerative Diseases
- Cancer, Hypoxia, and Metabolism
- Reconstructive Surgery and Microvascular Techniques
- Folate and B Vitamins Research
- Laser Applications in Dentistry and Medicine
- Birth, Development, and Health
- Lower Extremity Biomechanics and Pathologies
- Bone and Joint Diseases
- Receptor Mechanisms and Signaling
- Fatigue and fracture mechanics
- Osteoarthritis Treatment and Mechanisms
- Neurological Complications and Syndromes
Glostrup Hospital
2010-2022
Rigshospitalet
2016-2022
Copenhagen University Hospital
2010-2022
Zealand Pharma (Denmark)
2010
The ATP-gated receptor P2X7 (P2X7R) is involved in regulation of cell survival and has been interest cancer field. Pancreatic ductal adenocarcinoma (PDAC) a deadly new markers therapeutic targets are needed. PDAC characterized by complex tumour microenvironment, which includes pancreatic stellate cells (PSCs), potentially high nucleotide/side turnover. Our aim was to determine P2X7R expression function human vitro as well perform vivo efficacy study applying inhibitor an orthotopic xenograft...
Low-frequency 1q21.1 distal deletion and duplication copy number variant (CNV) carriers are predisposed to multiple neurodevelopmental disorders, including schizophrenia, autism intellectual disability. Human display a high prevalence of micro- macrocephaly in carriers, respectively. The underlying brain structural diversity remains largely unknown. We systematically called CNVs 38 cohorts from the large-scale ENIGMA-CNV collaboration UK Biobank identified 28 22 37,088 non-carriers (48%...
ABSTRACT Parathyroid hormone (PTH) and PTH(1-34) have been shown to promote bone healing in several animal studies. It is known that the mechanical environment important fracture healing. Furthermore, PTH loading has suggested synergistic effects on intact bone. The aim of present study was investigate whether effect rats influenced by reduced loading. For this purpose, we used female, 25-week-old ovariectomized rats. Animals were subjected closed midshaft right tibia 10 weeks after...
Teriparatide (Parathyroid hormone (PTH) 1-34) has been shown to increase bone mineral density (BMD) and reduce the risk of vertebral fractures when given intermittently. In contrast primary hyperparathyroidism (PHPT) is associated with increased loss. Moreover an occurrence cardiovascular disease (CVD) seen in PHPT patients. The N-terminal fragment pro-peptide Brain Natriuretic peptide (NT-proBNP), a marker CVD, be elevated patients, indicating that continuously high concentrations PTH...
Exercise is recommended as first-line treatment to reduce pain and improve physical function in patients with hip osteoarthritis, but the mechanism behind effect remains unknown. Blood urine were collected at baseline after 4 months of exercise from 60+-year-old persons (n = 39) osteoarthritis included a randomized controlled trial comparing effects strength training (ST), Nordic Walking (NW), unsupervised home-based (control). We measured biomarkers bone (N-terminal propeptide type I...
Increased incidence of bone fractures in the elderly is associated with gradual sarcopenia. Similar deterioration quality seen prolonged bed rest, spinal cord injuries or astronauts exposed to microgravity and, preceded by loss muscle mass. Signaling mechanisms involving uridine-5'-triphosphate (UTP) regulate homeostasis via P2Y2 receptors on osteoblasts and osteoclasts, whilst dictating cells' response mechanical loading. We hypothesized that paralysis-induced would be prevented receptor...
Low-frequency 1q21.1 distal deletion and duplication copy number variant (CNV) carriers are predisposed to multiple neurodevelopmental disorders including schizophrenia, autism intellectual disability. Human display a high prevalence of micro- macrocephaly in carriers, respectively. The underlying brain structural diversity remains largely unknown.We systematically called CNVs 38 cohorts from the large-scale ENIGMA-CNV collaboration UK biobank identified 28 22 37,088 non-carriers (48 % male)...
Searchable abstracts of presentations at key conferences on calcified tissues ISSN 2052-1219 (online)
Searchable abstracts of presentations at key conferences on calcified tissues ISSN 2052-1219 (online)