A5072416554- Diet and metabolism studies
- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Metabolism and Genetic Disorders
- Hemoglobinopathies and Related Disorders
- Neonatal and fetal brain pathology
- Diet, Metabolism, and Disease
- Education, Healthcare and Sociology Research
- Amino Acid Enzymes and Metabolism
- Infectious Encephalopathies and Encephalitis
- Nutrition, Genetics, and Disease
University of Oslo
2019-2024
Haukeland University Hospital
2024
Oslo University Hospital
2018-2024
St Olav's University Hospital
2024
Jazz Pharmaceuticals (United States)
2024
Angelini Pharma (Italy)
2024
Zero to Three
2023
Summary Objective Ketogenic diets reduce seizures in children with drug‐resistant epilepsy. Whether adults benefit from similar treatment has not been clarified. We therefore examined the efficacy of modified Atkins diet focal Methods performed a randomized clinical trial ( RCT ) patients >16 years who had at least 3 per month despite having tried antiepileptic drugs. They were to either 12 weeks on (diet group) or habitual (control group). Primary endpoint was change seizure frequency...
Abstract Objective The aim was to examine the influence of modified Atkins diet on serum concentration antiepileptic drugs (AEDs). Methods Prospective data from 63 adult patients with either focal or generalized drug‐resistant epilepsy recruited 12‐week dietary treatment as add‐on AEDs are analyzed. AED concentrations, ketones, glucose, and hemoglobin A1c were measured before after intervention. Paired t test used Spearman correlation coefficient, r , estimated. Results Mean age 37 years...
Abstract The implementation and potential of ketogenic dietary therapies (KDTs) have changed over time. organization KDT services, the availability multidisciplinary teams, resources support for patients families still vary widely around world. This diversity is reflected by a lack consistency in reported outcomes, optimization using compliance. To highlight unmet needs ERN EpiCARE Ketogenic Dietary Therapy Special Interest Group (KDT SIG) conducted an online survey on utilization,...
Abstract Objective The aim of this study was to investigate whether the modified Atkins diet (MAD), a variant ketogenic diet, has an impact on bone‐ and calcium (Ca) metabolism. Methods Two groups adult patients with pharmacoresistant epilepsy were investigated. One, group ( n = 53), treated MAD for 12 weeks, whereas other, reference 28), stayed their habitual in same period. All measurements performed before after weeks both groups. We assessed bone health by measuring parathyroid hormone...
The use of ketogenic diet as a supplement to antiseizure medication (ASM) in refractory epilepsy has increased the past decades. This high-fat, low-carbohydrate mimics metabolic state fasting and is generally well-tolerated. However, long-term adverse effects are unclear. purpose this study was investigate whether modified Atkins (MAD), variant diet, may have an impact on thyroid hormone levels.We assessed function by measuring stimulation (TSH), fT4, T3, fT3, rT3 before start (baseline)...
Ketogenic diets like the modified Atkins diet (MAD) are increasingly used in patients with refractory epilepsy. For epilepsy patients, stress is a well-known seizure-precipitating factor. New possibilities for measuring biomarkers of now available. The purpose this study was to investigate impact MAD on endocrine biomarkers.Forty-nine drug-resistant were investigated at baseline and after 12 weeks MAD. Cortisol cortisol-binding globulin (CBG) measured free cortisol index (FCI) calculated. We...
11.03.2024: Klinisk oversikt - Denne kliniske oversikten tar for seg behandling av status epilepticus, en tilstand der et epileptisk anfall varer lenge og medfører betydelig risiko hjerneskade død.
PurposeEpilepsy patients consider driving issues to be one of their most serious concerns. Ideally, decisions regarding fitness drive should based upon thorough evaluations by specialists in epilepsy care. In 2009, an EU directive was published aiming harmonize evaluation practices within European countries, but, despite these recommendations, whether all epileptologists use the same criteria is unclear. We therefore conducted this study investigate routine on how at centers evaluate...