A5000500200- Diet and metabolism studies
- Diabetes and associated disorders
- Vitamin D Research Studies
- Sleep and Wakefulness Research
- Hormonal and reproductive studies
- Pancreatic function and diabetes
- Sleep and related disorders
- Diabetes Management and Research
- Bone health and osteoporosis research
- Regulation of Appetite and Obesity
- Metabolism and Genetic Disorders
- Thyroid Disorders and Treatments
- Metabolism, Diabetes, and Cancer
- Adipokines, Inflammation, and Metabolic Diseases
- Stress Responses and Cortisol
- Adrenal Hormones and Disorders
- Biochemical Analysis and Sensing Techniques
- Diabetes Treatment and Management
- Sexual Differentiation and Disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Hormonal Regulation and Hypertension
- Adipose Tissue and Metabolism
- Birth, Development, and Health
- Cholesterol and Lipid Metabolism
- Restless Legs Syndrome Research
Oslo University Hospital
2016-2025
University of Oslo
2006-2025
Institutt for Eksperimentell Medisinsk Forskning
2025
Zero to Three
2023
California Center for Sleep Disorders
2018
Norwegian University of Science and Technology
2017
Akdeniz University Hospital
2005
Diabetes Research Center
2005
Diabetes Care & Hormone Clinic
2003
Keskuslaboratorio
2000
OBJECTIVE: To investigate whether serum levels of advanced glycation end products (AGEs) and the glycoxidation product Nepsilon-(carboxymethyl)lysine (CML) are increased in patients with type 2 diabetes compared nondiabetic control subjects AGEs and/or CML differ or without coronary heart disease (CHD). RESEARCH DESIGN AND METHODS: Serum were measured an immunoassay 32 men 21 women aged 59.3+/-6.2 years (means +/- SD) for 7.3 + 3.1 17 56.2+/-4.2 diabetes. Of diabetes, 18 had CHD. RESULTS:...
Narcolepsy type 1 (NT1) is caused by a loss of hypocretin/orexin transmission. Risk factors include pandemic 2009 H1N1 influenza A infection and immunization with Pandemrix®. Here, we dissect disease mechanisms interactions environmental triggers in multi-ethnic sample 6,073 cases 84,856 controls. We fine-mapped GWAS signals within HLA (DQ0602, DQB1*03:01 DPB1*04:02) discovered seven novel associations (CD207, NAB1, IKZF4-ERBB3, CTSC, DENND1B, SIRPG, PRF1). Significant at TRA DQB1*06:02 loci...
Abstract Background Gonadal function decades after treatment for childhood lymphoma (CL) is not well described. This cross‐sectional study had two aims: (1) describe long‐term gonadal and fertility in survivors (CLSs), (2) explore anti‐Mullerian hormone (AMH) as a measure of ovarian CLSs. Procedure Seventy‐four male 62 female CLSs participated survey consisting questionnaire, clinical examination, blood/semen analysis. Prior was categorized according to gonadotoxicity. Hypogonadism...
Objective To determine the relationship between serum total 25-hydroxyvitamin D (25(OH)D), directly measured free 25(OH)D and calculated with regard to vitamin D-binding protein (DBP) phenotypes, sex, BMI, age season, their interrelationship supplementation. Design, patients interventions A randomized controlled trial 20 000 IU of 3 per week or placebo for 12 months was designed. 472 subjects, 236 in each intervention groups, were included analyses. Main outcome measures Baseline...
It is well known that anti-GAD (glutamic acid decarboxylase) serves as a marker for development of autoimmune diabetes in adults. On the other hand, clinical implications positivity persistently non-diabetic (PND) adults are poorly elucidated. Our aim was to establish frequency PNDs an all-population-based cohort from Nord-Trøndelag health study (HUNT) and prospectively test associations with glucose tolerance thyroid autoimmunity.We formed primary population (4496 individuals), selected...
The cosyntropin test is used to diagnose adrenal insufficiency (AI) and nonclassical congenital hyperplasia (NCCAH). Current cutoffs for cortisol 17-hydroxyprogesterone (17-OHP) are derived from nonstandardized immunoassays. Liquid chromatography tandem mass spectrometry (LC-MS/MS) offers direct measurement of steroids, prompting the need re-establish normal ranges. goal this study was define cutoff values 17-OHP in serum by LC-MS/MS 30 60 minutes after intravenous administration 250 µg...
Abstract Aims In the current paper, we aim to explore effect of both and former long-term anabolic-androgenic steroid (AAS) use on regulation systemic inflammatory markers mediators extracellular matrix (ECM) remodelling their association with hormones echocardiographic myocardial pathology in weightlifters. Methods results a cross-sectional study, 93 weightlifting AAS users, whom 62 were 31 past at least 1-year cumulative (mean 11 ± 7 accumulated years use), compared 54 non-using controls...
ABSTRACT Purpose The effect of exercise on serum concentration vitamin D metabolites remains inconclusive, with studies reporting deviating results. This study evaluated the acute a single session two specific forms; strength training (ST) and high-intensity interval (HIIT), circulating 25-hydroxyvitamin (25(OH)D), free25(OH)D 1,25-dihydroxyvitamin (1,25(OH) 2 D), skeletal muscle receptor (VDR) gene expression, in healthy adults. Methods Thirty-nine participants (19 women 20 men, age 21–30...
Abstract Objectives Allogeneic hematopoietic stem cell transplantation (HSCT) is associated with nutritional risks. This study describes vitamin D status and intake in children undergoing HSCT compares results to healthy children. Methods In a prospective observational study, 25(OH)D 1,25(OH) 2 were assessed at hospital admission before (baseline), 3‐month 1‐year post‐transplant. Vitamin deficiency was defined as < 50 nmol/L. A 4‐day diet record 3‐months 1‐year. Healthy once. Results...
Mutations in the hepatocyte nuclear factor (HNF)-1α gene cause maturity-onset diabetes of young (MODY), type 3. To estimate prevalence MODY3 Norwegian diabetic pedigrees, we screened a total 130 families for HNF-1α mutations; 42 with clinical MODY, 75 suspected and 13 pedigrees multiplex 1 diabetes. Twenty-two 15 one family harbored mutations. Thus, about half mutations could be detected. Eight 18 different identified were novel (G47E, T196fsdelCCAA, IVS3–1G>A, S256T, A276D, S445fsdelAG,...
To ensure optimal calcium accrual in the fetal skeleton, a substantial rise occurs 1,25-dihydroxyvitamin D (1,25(OH)2D), but is dependent on sufficient 25-hydroxyvitamin (25(OH)D). Large longitudinal studies addressing free 25(OH)D and 1,25(OH)2D during pregnancy are scarce. We aimed to assess levels of relationship between 25(OH)D, 1,25(OH)2D, vitamin D-binding protein (DBP), parathyroid hormone (PTH), pregnancy; determinants status; association indices or PTH outcomes (gestational diabetes...
The gut hormone ghrelin drives food motivation and increases intake, but it is also involved in the anticipation of response to rewards other than food. This pre-registered study investigated how naturally varying concentrations affect processing touch as a social reward humans. Sixty-seven volunteers received slow caressing (so-called CT-targeted touch) control on their shins during 3T functional imaging two test days. On one occasion, participants were fasted, another, they meal. each...
Graves' orbitopathy (GO) is a severe organ-specific autoimmune inflammatory ocular complication most often associated with disease (GD). Besides the cosmetic problems these patients develop, GO may also cause severe, sight-threatening complications. Additionally, complicates treatment of GD, making identification Graves at risk for eye before they develop symptoms critical step in clinical management and quality life patients. The high concentration proteins tear fluid makes it an important...
In observational studies, vitamin D deficiency is a risk factor for low bone density and future fractures, whereas causal relation has been difficult to show in randomized controlled trials (RCTs). Similarly, associated with increased turnover, but RCTs have not shown conclusive effects. This could be due inclusion of sufficient subjects doses. the present study 399 mean baseline serum 25-hydroxyvitamin (25(OH)D) 34.0 nmol/L completed four months intervention D3 20,000 IU per week versus...
High-doses of anabolic-androgenic steroids (AAS) is efficient for building muscle mass, but pose a risk cardiovascular side effects. Little known the effect AAS on vasculature, previous findings suggest unfavorable alterations in vessel walls and vasoreactivity. Here, long-term vascular function morphology were examined male weightlifters, mimicking animal model. Arterial elasticity tested with ultrasound, pulse wave velocity (PWV) carotid intima media thickness (cIMT) 56 current users, 67...
ObjectiveTo define liquid chromatography tandem mass spectrometry (LC-MS/MS)–based cutoff levels and panels of steroid hormones, to improve diagnosis nonclassic congenital adrenal hyperplasia (NCCAH) other partial enzyme defects in the adrenals.DesignProspective cohort analysis.SettingUniversity hospital-based tertiary endocrine center.PatientsOne hundred twenty-one healthy adults 65 patients evaluated for possible NCCAH (validation cohort).InterventionsThe LC-MS/MS–determined cutoffs 11...
There was more than a 10-fold increase in the incidence of narcolepsy type 1 (NT1) after H1N1 mass vaccination 2009/2010 several countries. NT1 is associated with loss and cell groups hypothalamus which may be secondary affected sub-cortical cortical gray matter. We performed case-control comparison MRI-based global volume thickness post-H1N1 patients compared controls.
To assess white matter involvement in H1N1-vaccinated hypocretin deficient patients with narcolepsy type 1 (NT1) compared first-degree relatives (a potential risk group) and healthy controls. We four diffusion tensor imaging–based microstructural indices (fractional anisotropy [FA], mean diffusivity [MD], radial [RD], axial [AD]) 57 NT1 (39 females, age 21.8 years, 51/57 H1N1-vaccinated, 57/57 HLA-DQB1*06:02-positive, 54/54 hypocretin-deficient), 54 (29 19.1 37/54 32/54...