A5051598091- Medical Imaging Techniques and Applications
- Cancer, Hypoxia, and Metabolism
- Lung Cancer Treatments and Mutations
- Radiomics and Machine Learning in Medical Imaging
- Radiopharmaceutical Chemistry and Applications
- Lung Cancer Diagnosis and Treatment
- Cardiac Imaging and Diagnostics
- Medical Imaging and Pathology Studies
- MRI in cancer diagnosis
- Neurological Disease Mechanisms and Treatments
- Cancer Immunotherapy and Biomarkers
- Advanced MRI Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Nanoplatforms for cancer theranostics
- Lymphoma Diagnosis and Treatment
- Dementia and Cognitive Impairment Research
- Breast Cancer Treatment Studies
- Glioma Diagnosis and Treatment
- Optical Imaging and Spectroscopy Techniques
- Lung Cancer Research Studies
- Myasthenia Gravis and Thymoma
- Alzheimer's disease research and treatments
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cancer, Lipids, and Metabolism
Saitama Medical University
2016-2025
Taiho Pharmaceutical (Japan)
2022
Eli Lilly (Japan)
2022
Ono Pharmaceutical (Japan)
2022
Saitama International Medical Center
2011-2021
Saitama University
2020-2021
Saitama Medical University Hospital
2007-2020
Kanazawa University Hospital
2004-2006
Tohoku University
2005
Suzuki (Japan)
2005
Abstract BACKGROUND The accuracy of fluorodeoxyglucose positron emission tomography (FDG‐PET; dual‐head camera with attenuation correction) and Ga‐67 scintigraphy was compared to identify disease sites in patients Hodgkin (HD) intermediate high‐grade non‐Hodgkin lymphoma (NHL) at initial diagnosis or clinical recurrence. METHODS Fifty‐one contemporaneous FDG‐PET scintigraphies were performed on NHL (35 grade, 3 high grade) HD (13 patients). Sites correlated a site‐by‐site basis images....
Eribulin mesylate (eribulin) is a first-in-class halichondrin B-based microtubule dynamics inhibitor. To compare the anti-angiogenic activity of eribulin to that bevacizumab, we compared tumour vessel remodelling and reoxygenation between two agents. Patients with advanced breast cancer stage III/IV were eligible for study. assigned receive either or single-agent bevacizumab. Tissue concentrations oxyhaemoglobin (O2Hb) deoxyhaemoglobin (HHb), oxygen saturation (SO2) tumours before day 7...
To investigate the improvement of prognostication active bone metastatic burden by discriminating metastases from degenerative changes in hot foci, using skeletal standardized uptake values (SUVs) quantitative single photon emission tomography/computed tomography (SPECT/CT) patients with prostate cancer.We investigated 170 cancer who underwent SPECT/CT 99mTc-methylene-diphosphonate (MDP), through conjugate gradient reconstruction tissue zoning, attenuation, and scatter corrections applied,...
Purpose: Bevacizumab, an antibody against endothelial growth factor, is a key but controversial drug in the treatment of metastatic breast cancer. We, therefore, aimed to determine intrinsic resistance bevacizumab at physiologic and molecular levels advanced cancer using PET, dynamic contrast-enhanced MRI, diffuse optical spectroscopic imaging (DOSI), multiplex cytokine assays.Experimental Design: In total, 28 patients diagnosed with stage III/IV receiving single-agent for 1 week followed by...
It remains unclear whether the accumulation of 2-deoxy-2-[18F]fluoro-d-glucose (18F-FDG) before initiation anti-programmed death-1 (PD-1) antibody can predict outcome after its treatment. The aim this study is to retrospectively examine prognostic significance 18F-FDG uptake as a predictive marker anti-PD-1 antibody. Eighty-five patients with previously treated non-small cell lung cancer (NSCLC) who underwent 18F-FDG-positron emission tomography (PET) just administration nivolumab or...
Abstract A 75-year-old woman with Takayasu arteritis was referred to 18 F-FDG PET/CT due elevated C-reactive protein in her laboratory data. FDG semiconductor detectors revealed no uptake the arterial walls, suggesting active inflammation. However, blood pool proximal portion of left subclavian artery defective, occlusion. Magnetic resonance angiography complete occlusion artery. Ultrasonography showed reverse flow vertebral Semiconductor PET can visualize defects intra-arterial branches from aorta.
Background and aim In Alzheimer's disease (AD), regional cerebral blood flow (rCBF) in the posterior cingulate gyrus precuneus has been reported to decrease even at a very early stage. We performed multicentre SPECT study evaluate discrimination ability of an easy Z-score imaging system (eZIS) by detecting rCBF this area with common normal database between AD patients stage mild cognitive impairment age-matched healthy volunteers. Methods Brain perfusion images 40 volunteers were acquired...
Abstract There is a lack of markers for predicting favorable outcomes after pembrolizumab therapy in patients with non-small cell lung cancer (NSCLC) programmed death ligand-1 (PD-L1) expression ≥ 50%. This retrospective study examined the prognostic significance 2-deoxy-2-[18F] fluoro- d -glucose ( 18 F-FDG) uptake as predictive marker first-line pembrolizumab. Forty-eight previously untreated NSCLC and PD-L1 levels 50% who underwent F-FDG-positron emission tomography (PET) just before...
The aim of the present study was to explore relationship between tumor metabolic glycolysis and inflammatory or nutritional status in patients with advanced non‑small cell lung cancer (NSCLC) who received programmed death‑1 (PD‑1) blockade. A total 186 were registered study. All underwent <sup>18</sup>F‑FDG PET imaging before initial PD‑1 blockade, maximum standardized uptake value (SUV<sub>max</sub>), volume (MTV) lesion (TLG) assessed as indicators uptake. As index, neutrophil lymphocyte...
Abstract Background Near-infrared optical imaging targeting the intrinsic contrast of tissue hemoglobin has emerged as a promising approach for visualization vascularity in cancer research. We evaluated usefulness diffuse spectroscopy using time-resolved spectroscopic (TRS) measurements functional primary breast cancer. Methods Fifty-five consecutive TNM stageI/II patients with histologically proven invasive ductal carcinoma and operable tumors (<5 cm) who underwent TRS were enrolled....
Diffuse optical spectroscopic imaging (DOSI) is used as an indicator of tumor blood volume quantified by tissue hemoglobin concentrations. We aimed to determine whether early changes in total (tHb) concentration can predict a pathologic complete response (pCR) neoadjuvant chemotherapy patients with operable breast cancer, and we compared the predictive value pCR between DOSI <sup>18</sup>F-FDG PET combined CT. <b>Methods:</b> Of 100 enrolled, 84 were prospectively evaluated for primary...
Purpose Optical imaging techniques for measuring tissue hemoglobin concentration have been recently accepted as a way to assess tumor vascularity and oxygenation. We investigated the correlation between early optical response single-agent bevacizumab treatment outcome. Methods Seven patients with advanced or metastatic breast cancer were treated followed by addition of weekly paclitaxel. patient's breasts was performed measure total (tHb) oxygen saturation (stO2) at baseline on days 1, 3, 6,...
Abstract Anti-programmed death-1 (PD-1) blockade is a standard treatment for advanced non-small-cell lung cancer (NSCLC). However, no appropriate modality exists monitoring its therapeutic response immediately after initiation. Therefore, we aimed to elucidate the clinical relevance of 18 F-FDG PET/CT versus CT in predicting PD-1 early phase. This prospective study included total 54 NSCLC patients. was performed at 4 weeks and 9 monotherapy. Maximum standardized uptake values (SUL max ),...
Nanoparticle albumin-bound paclitaxel (nab-PTX) is a solvent-free coupled to human albumin without an associated increase in toxicity. The neoadjuvant study of primary breast cancer was planned evaluate tumor response and safety triweekly nanoparticle paclitaxel.Patients with Stage II/III HER2-negative received four courses 260 mg/m(2) every 3 weeks (q3w), followed by epirubicin 90 plus cyclophosphamide 600 q3w. Tumor after histologically evaluated. In addition, the clinical response,...