A5017891540- Medical Imaging Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- Neuroscience and Neuropharmacology Research
- Nicotinic Acetylcholine Receptors Study
- Alzheimer's disease research and treatments
- Advanced MRI Techniques and Applications
- Particle Detector Development and Performance
- Cholinesterase and Neurodegenerative Diseases
- Radiation Detection and Scintillator Technologies
- Radiomics and Machine Learning in Medical Imaging
- Glioma Diagnosis and Treatment
- Cardiac Imaging and Diagnostics
- Traumatic Brain Injury and Neurovascular Disturbances
- Receptor Mechanisms and Signaling
- Medical Imaging and Pathology Studies
- Computational Drug Discovery Methods
- Cancer, Hypoxia, and Metabolism
- Pancreatic function and diabetes
- Hepatocellular Carcinoma Treatment and Prognosis
- Lanthanide and Transition Metal Complexes
- Advanced Radiotherapy Techniques
- Neuroendocrine Tumor Research Advances
- Synthesis and Biological Evaluation
- Neuroinflammation and Neurodegeneration Mechanisms
- Peptidase Inhibition and Analysis
Kyoto Pharmaceutical University
2009-2024
National Cerebral and Cardiovascular Center
2011-2024
Kyoto University
2009-2021
Health Sciences University of Hokkaido
2014-2018
Kyoto University Hospital
2006-2012
Osaka City University
2006
Nagasaki University
2006
Foundation for Biomedical Research and Innovation
2005
Chiba University
2002
Arginine vasopressin modulates the release of adrenocorticotropic hormone, beta-endorphin, and prolactin from anterior pituitary. Release is mediated by V1b receptor through mobilization intracellular Ca2+ phosphatidylinositol hydrolysis. In contrast to its well characterized peripheral actions, such as antidiuresis, contraction vascular smooth muscle, stimulation hepatic glycogenolysis, exact site mechanism action in pituitary remain unclear. This largely due a lack information on molecular...
A novel series of benzofuran derivatives as potential positron emission tomography (PET) tracers targeting amyloid plaques in Alzheimer's disease (AD) were synthesized and evaluated. The syntheses benzofurans successfully achieved by an intramolecular Wittig reaction between triphenylphosphonium salt 4-nitrobenzoyl chloride. When vitro binding studies using AD brain gray matter homogenates carried out with a derivatives, all the examined displayed high affinities Ki values subnanomolar...
The purpose of this report was to investigate the potential positron emission tomography using F-18 fluorodeoxythymidine (FLT-PET) in evaluating primary brain tumors.FLT-PET performed 25 patients with tumors. FLT uptake lesion semiquantitatively evaluated by measuring maximal standardized value (SUVmax) and tumor-to-normal tissue ratio (TNR). SUVmax TNR were compared histologic grade expression proliferation marker (Ki-67).FLT normal parenchyma very low, resulting visualization tumors high...
Nicotinic acetylcholine receptors (nAChRs) are of great interest because they implicated in various brain functions. They also thought to play an important role nicotine addiction smokers. Chronic (-)-nicotine, a nAChR agonist, treatment mice and rats elicits dose-dependent increase nAChRs the brain. Upregulation postmortem human brains smokers has been reported. However, changes after cigarette smoking cessation humans poorly understood. The aim this study was detect dynamic living...
A physical 3-dimensional phantom that simulates PET/SPECT images of static regional cerebral blood flow in grey matter with a realistic head contour has been developed. This study examined the feasibility using this for evaluating images.The was constructed transparent, hydrophobic photo-curable polymer laser-modelling technique. The designed to contain matter, skull, and trachea spaces filled radioactive solution, bone-equivalent solution K(2)HPO(4), air, respectively. bone compartments...
This paper describes the synthesis and biological evaluation of fluoro-pegylated (FPEG) chalcones for imaging β-amyloid (Aβ) plaques in patients with Alzheimer's disease (AD). FPEG chalcone derivatives were prepared by aldol condensation reaction. In binding experiments conducted vitro using Aβ(1−42) aggregates, having a dimethylamino group showed higher Ki values (20−50 nM) than those monomethylamino or primary amine group. When biodistribution 11C-labeled dimethyamino was examined normal...
A series of fluorinated benzofuran derivatives as potential tracers for positron emission tomography (PET) targeting β-amyloid plaques in the brains patients with Alzheimer's disease (AD) were synthesized and evaluated. The produced using an intramolecular Wittig reaction. In experiments vitro, all displayed high affinity Aβ(1-42) aggregates K i values nanomolar range. Radiofluorinated 17, [(18)F]17, particular labeled sections Tg2576 mouse brain uptake (5.66% ID/g) at 10 min postinjection,...
Use of 15O labeled oxygen (15O2) and positron emission tomography (PET) allows quantitative assessment the regional metabolic rate (CMRO2) in vivo, which is essential to understanding pathological status patients with cerebral vascular neurological disorders. The method has, however, been challenging, when a 3D PET scanner employed, largely attributed presence gaseous radioactivity trachea inhalation system, results large amount scatter random events assessment. present study was intended...
Direct radioiodination of peptides using copper-mediated iododeboronation is a promising radiosynthetic method for solving issues classical direct radiolabeling, such as toxicity the organotin precursor (iododestannylation) or formation radio byproducts (by electrophilic iodination tyrosine residue). However, parameters optimizing reaction conditions various are not completely understood. In particular, considering peptide solubility, effects water-containing solvents on labeling efficiency...