A5078489553- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Medical Imaging Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- Cancer Cells and Metastasis
- Receptor Mechanisms and Signaling
- Platelet Disorders and Treatments
- Molecular Sensors and Ion Detection
- Chemical Reactions and Isotopes
- Cholesterol and Lipid Metabolism
- Lung Cancer Treatments and Mutations
- Synthesis of heterocyclic compounds
- Chemical Reaction Mechanisms
- Cholinesterase and Neurodegenerative Diseases
- Parkinson's Disease Mechanisms and Treatments
- Barrier Structure and Function Studies
- bioluminescence and chemiluminescence research
- S100 Proteins and Annexins
- Neurological Disease Mechanisms and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- CAR-T cell therapy research
- Lung Cancer Research Studies
- Immune cells in cancer
- Alzheimer's disease research and treatments
- Cancer therapeutics and mechanisms
Nanjing Medical University
2015-2024
Bengbu Medical College
2024
National Institutes for Quantum Science and Technology
2011-2013
Japan Proton Accelerator Research Complex
2001
Abstract Background [ 11 C]pyridinyl‐butadienyl‐benzothiazole 3 is a PET imaging agent designed for capturing pathological tau aggregates in diverse neurodegenerative disorders, and would be of clinical utility neuropathological investigations PSP. Objectives To explore the usefulness 3/PET assessing characteristic distributions pathologies their association with symptoms brains living PSP patients. Methods We assessed 13 patients age‐matched healthy control subjects. Individuals negative...
N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-4-(11)C-methoxy-N-methylbenzamide ((11)C-ITMM) is a potential radioligand for mapping metabotropic glutamate receptor type 1 (mGluR1) in the brain by PET. The present study was performed to determine safety, distribution, radiation dosimetry, and initial imaging of (11)C-ITMM healthy human subjects.The multiorgan biodistribution dosimetry were assessed 3 subjects, who underwent 2-h whole-body PET scans. Radiation estimated from...
Introduction Pancreatic cancer is an aggressive and its prognosis remains poor. Therefore, additional effective therapy required to augment and/or complement current therapy. CD147, high expression in pancreatic cancer, involved the metastatic process considered a good candidate for targeted CD147-specfic imaging could be useful selection of appropriate patients. we evaluated potential fully human anti-CD147 monoclonal antibody 059-053 as new positron emission tomography (PET) probe cancer....
The C2A domain of synaptotagmin I can target apoptotic cells by binding to exposed anionic phospholipids. goal this study was synthesize and develop <sup>18</sup>F-labeled C2A-glutathione-<i>S</i>-transferase (GST) as a molecular imaging probe for the detection apoptosis assess response paclitaxel chemotherapy in VX2 rabbit lung cancer. <b>Methods:</b><sup>18</sup>F-C2A-GST prepared labeling C2A-GST with <i>N</i>-succinimidyl 4-<sup>18</sup>F-fluorobenzoate (<sup>18</sup>F-SFB)....
Subarachnoid hemorrhage (SAH), a stroke subtype associated with high mortality, is closely linked to neuroinflammation. Phloretin, naturally occurring flavonoid abundant in fruits, possesses anti-inflammatory properties. However, its specific role SAH remains unclear. Therefore, we aimed investigate the potential of phloretin SAH. We established vitro and vivo models assess effects phloretin. Subsequently, utilizing SAH-related public datasets from GEO database, identified key genes...