A5036336235- Moyamoya disease diagnosis and treatment
- Glioma Diagnosis and Treatment
- Cerebrovascular and Carotid Artery Diseases
- Intracranial Aneurysms: Treatment and Complications
- Neurological Complications and Syndromes
- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Cerebrospinal fluid and hydrocephalus
- Meningioma and schwannoma management
- Cancer, Hypoxia, and Metabolism
- Radiomics and Machine Learning in Medical Imaging
- MRI in cancer diagnosis
- Medical Imaging Techniques and Applications
- Head and Neck Surgical Oncology
- Vascular Malformations Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Trigeminal Neuralgia and Treatments
- Acute Ischemic Stroke Management
- Aortic Disease and Treatment Approaches
- Hepatitis C virus research
- Neurosurgical Procedures and Complications
- Bone Tumor Diagnosis and Treatments
- Brain Metastases and Treatment
- Fetal and Pediatric Neurological Disorders
- Cerebral Venous Sinus Thrombosis
Tokyo Medical and Dental University
2016-2025
Shanghai Institute for Science of Science
2024
The University of Tokyo
2013-2024
Nerima General Hospital
2024
Tokyo Metropolitan Institute of Gerontology
2023
Oxford University Press (United Kingdom)
2020
Osaka Electro-Communication University
2017
European Foundation for the Study of Chronic Liver Failure
2016
Georgia Institute of Technology
2014
National Institute of Neurological Disorders and Stroke
2014
Hepatitis C virus (HCV) populations in vivo consist of heterogeneous mixtures genetically different but closely related variants defined as a 'quasispecies'. The longitudinal fluctuation HCV quasispecies chronic hepatitis has not been elucidated. Serial plasma samples were obtained from four patients with (two without any treatment and two treated interferon), cDNA fragments containing the 5′-terminal region E2 gene amplified RNA using PCR. Since conventional cloning PCR products detects...
Object The authors retrospectively analyzed the data obtained in patients who had undergone l-[methyl-11C] methionine (MET)—positron emission tomography (PET) studies to clarify relationship between MET uptake and tumor biological features discuss clinical usefulness of MET-PET studies. Methods One hundred ninety-four with cerebral glioma or suspected underwent PET scanning 20 minutes after injection MET, whose into was expressed as a ratio contralateral healthy brain tissue (T/N ratio)....
<h3>BACKGROUND AND PURPOSE:</h3> Early evaluation of the pyramidal tract is a prerequisite in patients with intracerebral hemorrhage (ICH) order to decide optimal treatment or assess appropriate rehabilitation. The aim this study was evaluate and predict neuromotor functional outcome an ICH by using diffusion tensor imaging (DTI) acute phase. <h3>MATERIALS METHODS:</h3> Eighteen hemiparetic supratentorial were prospectively studied DTI within 2 days after onset. A region-of-interest-based...
<h3>Importance</h3> An adequate system for triaging patients with head trauma in prehospital settings and choosing optimal medical institutions is essential improving the prognosis of these patients. To our knowledge, there has been no established way to stratify based on their severity that can be used by ambulance crews at an injury site. <h3>Objectives</h3> develop a triage according using several machine learning techniques evaluate predictive accuracy techniques. <h3>Design, Setting,...
Moyamoya disease (MMD) causes cerebral arterial stenosis and hemodynamic disturbance, the latter of which may disrupt glymphatic system activity, waste clearance system. We evaluated 46 adult patients with MMD 33 age- sex-matched controls using diffusivity along perivascular space (ALPS) measured diffusion tensor imaging (ALPS index), partly reflect multishell MRI to generate freewater maps. Twenty-three were also via 15 O-gas positron emission tomography (PET), all underwent cognitive...
<i>Background:</i> Acute blood pressure (BP) elevation and cardiac abnormalities are known to follow ischemic stroke. Brain natriuretic peptide (BNP), which is produced in response such cardiovascular alterations, expected play a hemodynamic role. We measured plasma BNP concentrations patients with cerebral infarction (CI) determine the implications of acute <i>Methods:</i> Eighty-eight CI, 59 essential hypertension, 44 spontaneous intracerebral hemorrhage, 22...
A multimodal neuronavigation system using metabolic images with PET and anatomical from MR is described here for glioma surgery. The efficacy of the was evaluated by comparing results that conventional navigation system, which routinely uses CT imaging as guides.Thirty-three patients cerebral underwent 36 operations aid either a or system. All were preliminarily examined l-methyl-[11C] methionine (MET) surgical planning. Seventeen performed integrating MET-PET images. other 19 based solely...
<h3>BACKGROUND AND PURPOSE:</h3> Arterial spin-labeling MR imaging with multiple postlabeling delays has a potential to evaluate various hemodynamic parameters. To clarify whether arterial can identify CBF and perfusion delay in patients Moyamoya disease, we compared spin-labeling, DSC, <sup>15</sup>O-gas PET terms of their ability these <h3>MATERIALS METHODS:</h3> Eighteen disease (5 men, 13 women; ages, 21–55 years) were retrospectively analyzed. values pulsed continuous using 2 (short...
We examined whether the degree of hemodynamic stress in patients with chronic occlusive cerebral vascular disease can be quantitatively evaluated use perfusion-weighted magnetic resonance imaging (PWI). Thirty-six moyamoya (mean age, 26.8 years; range, 18 to 59) underwent PWI and positron emission tomography (PET) within a month's interval. The data were calculated by three different analytic methods. blood flow (CBF) ratio, volume (CBV) mean transit time (MTT) anterior circulation using...
Arterial spin labeling (ASL) and dynamic susceptibility contrast (DSC) magnetic resonance imaging (MRI) are widely used to image cerebral blood flow (CBF) in stroke. This study examined how changes tissue spin-lattice relaxation-time constant ( T 1 ), blood-brain barrier (BBB) permeability, transit time affect CBF quantification by ASL DSC postischemic hyperperfusion the same animals. In Group I n = 6), embolic stroke rats imaged 48hours after showed regional hyperperfusion. normal pixels,...
Surgical revascularization is considered an effective treatment for juvenile patients with moyamoya disease (MMD). Yet the long-term outcome in surgically treated still needs to be clarified. More than 30 years have passed since authors' department started intensively treating pediatric MMD using indirect anastomosis techniques. In this study authors surveyed current status of these patients.Activities daily living (ADLs) were and present clinical was assessed based on modified Rankin scale...
Background and Purpose ―Microstructural damage in the brain induced by chronic ischemia is suggested to play a pivotal role neurocognitive dysfunction of adults with Moyamoya disease (MMD). We investigated specific changes microstructure their correlations patients MMD using multishell diffusion magnetic resonance imaging technique called neurite orientation dispersion density imaging. Methods— evaluated 26 (16–63 years old, 20 females) age- sex-matched normal volunteers neuropsychological...
OBJECTIVE The aim of this study was to evaluate whether indirect revascularization in pediatric patients with moyamoya disease leads periventricular anastomosis (PVA) regression, which is markedly developed vessels and regarded as a risk factor for hemorrhage. METHODS Pediatric treated from 2011 2021 were included study. Magnetic resonance angiography arterial spin labeling images acquired before 1 year after surgery assessed obtain visual scale postoperative collateral artery formation,...
Stereotactic radiosurgery with gamma knife (GK-SRS) generally improves the focal control of brain metastases. Yet in cases recurrence at a previous radiation site, MRI is often imperfect differentiating between active tumor and injury. We have examined whether use C methionine (MET) PET will facilitate this differentiation improve outcome GK-SRS for focally recurrent metastases after prior treatment.Eighty-eight patients underwent postirradiation Thirty-four received areas manifesting high...
Precise evaluation of hemodynamic stress is important for the treatment moyamoya disease (MMD).To explore whether dynamic susceptibility contrast magnetic resonance imaging could predict effects and risk indirect bypass surgery on MMD.Clinical data patients with MMD who were evaluated preoperatively postoperatively digital subtraction angiography retrospectively. Indirect was performed 115 hemispheres 69 (mean age, 15 years; range, 3-54 years). We examined correlations ischemic events...
Many MRI parameters have been explored and demonstrated the capability or potential to evaluate acute stroke injury, providing anatomical, microstructural, functional, neurochemical information for diagnostic purposes therapeutic development. However, application of multiparameter approach is hindered in clinic due very limited time window after insult. Parallel imaging technique can accelerate data acquisition dramatically has incorporated modern clinical scanners increasingly applied...