A5025323344- Endoplasmic Reticulum Stress and Disease
- Parkinson's Disease Mechanisms and Treatments
- Autophagy in Disease and Therapy
- Neuroinflammation and Neurodegeneration Mechanisms
- Mechanisms of cancer metastasis
- Tryptophan and brain disorders
- Genomics, phytochemicals, and oxidative stress
- Biochemical Acid Research Studies
- Biochemical and biochemical processes
- RNA regulation and disease
- Vitamin C and Antioxidants Research
- Immune Cell Function and Interaction
- Liver physiology and pathology
- Paraoxonase enzyme and polymorphisms
- Cancer Mechanisms and Therapy
- Calcium signaling and nucleotide metabolism
- Amyotrophic Lateral Sclerosis Research
- Adenosine and Purinergic Signaling
- Optimism, Hope, and Well-being
- Cystic Fibrosis Research Advances
- Galectins and Cancer Biology
- Asthma and respiratory diseases
- Alcoholism and Thiamine Deficiency
- Neonatal Respiratory Health Research
- Nerve injury and regeneration
Kanazawa University
2010-2020
Japan Science and Technology Agency
2010-2014
Centre for Research in Engineering Surface Technology
2010
Center for Responsible Travel
2010
Science and Technology Corporation (United States)
2010
Centre de Recherche en Économie et Statistique
2010
Abstract Background Both resveratrol and vitamin C (ascorbic acid) are frequently used in complementary alternative medicine. However, little is known about the underlying mechanisms for potential health benefits of its interactions with ascorbic acid. Methods The antioxidant enzymes heme oxygenase-1 paraoxonase-1 were analysed their mRNA protein levels HUH7 liver cells treated 10 25 μmol/l absence presence 100 1000 Additionally transactivation transcription factor Nrf2 determined by...
Accumulating evidence suggests a crucial role for the unfolded protein response (UPR) in Parkinson's disease (PD). In this study, we investigated relevance of UPR mouse model chronic MPTP/probenecid (MPTP/P) injection, which causes severe and persistent degeneration dopaminergic neurons. Enhanced activation branches, including ATF6α PERK/eIF2α/ATF4, was observed after MPTP/P injections into mice. Deletion gene accelerated neuronal ubiquitin accumulation relatively early injection course....
CD157, known as bone marrow stromal cell antigen-1, is a glycosylphosphatidylinositol-anchored ADP-ribosyl cyclase that supports the survival and function of B-lymphocytes hematopoietic or intestinal stem cells. Although CD157/Bst1 risk locus in Parkinson's disease (PD), little about CD157 nervous system contribution to PD progression. Here, we show no apparent motor dysfunction was observed young knockout (CD157 (-/-)) male mice under less aging-related effects on behaviors. (-/-) exhibited...
Abstract To dissect the role of endoplasmic reticulum (ER) stress and unfolded protein response in brain ischemia, we investigated relevance activating transcription factor 6α (ATF6α), a master transcriptional response, after permanent middle cerebral artery occlusion (MCAO) mice. Enhanced expression glucose‐regulated protein78, downstream molecular chaperone ATF6α, was observed both neurons glia peri‐infarct region wild‐type mice MCAO. Analysis using Atf6 α −/− revealed larger infarct...
Accumulating evidence suggests a critical role for the unfolded protein response in multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). In this study, we investigated relevance of activating transcription factor 6α (ATF6α), an upstream regulator part response, EAE. The expressions ATF6α-target molecular chaperones such as glucose-regulated 78 (GRP78) 94 (GRP94) were enhanced acute inflammatory phase after induction Deletion Atf6α suppressed...
Novel therapeutics that can activate the microglial Nrf2 pathway contribute to neuronal survival in neuroinflammatory conditions.
ABSTRACT Oxidative stress is implicated in the pathogenesis of various neurodegenerative diseases including Parkinson's disease (PD). 3,4‐Dihydroxybenzalacetone (DBL) a small catechol‐containing compound isolated from Chaga ( Inonotus obliquus [persoon] Pilat), and has been reported to have beneficial bioactivities, antioxidative, anti‐inflammatory, anti‐tumorigenic activities, with relatively low toxicity normal cells. We, therefore, investigated neuroprotective activity DBL against...
Although intracellular stresses are believed to be involved in the process of neurodegeneration, it is not fully understood how one stress/stress response affects another. Herp an endoplasmic reticulum (ER)-located membrane protein proposed function ER-associated degradation (ERAD). strongly induced by ER stress but rapidly degraded proteasome. To elucidate effect expression on proteolytic caused impairment ubiquitin-proteasome system (UPS), we utilized 293T knockdown (KD) cells and F9...
Activation of glia has been observed in various neurodegenerative diseases. Excessive production nitric oxide (NO), as a consequence increased inducible synthase (iNOS) glia, contributes to the neurodegeneration. The enhancement intracellular stresses such oxidative stress and endoplasmic reticulum (ER) also implicated several disorders. During search for compounds that regulate ER stress, dibenzoylmethane derivative, 2,2′-dimethoxydibenzoylmethane (DBM 14-26), was identified novel...
Herp is an endoplasmic reticulum- (ER-) resident membrane protein that plays a role in ER-associated degradation. We studied the expression of and its effect on neurodegeneration mouse model Parkinson's disease (PD), which both oxidative stress ER are evoked. Eight hours after administering PD-related neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), to mice, increased at mRNA levels. Experiments using Herpud1 (+/+) (-/-) mice revealed status acute degeneration nigrostriatal...